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This volume details a collection of state-of-art methods including identification of novel ncRNAs and their targets, functional annotation and disease association in different biological contexts. Chapters guide readers through an overview of disease-specific ncRNAs, computational methods and workflows for ncRNA discovery, annotation based on high-throughput sequencing data, bioinformatics tools and databases for ncRNA analyses, network-based methods, and kinetic modelling of ncRNA-mediated gene regulation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Biology of Non-Coding RNA: Methods and Protocols aims to provide a state-of-the-art collection of computational methods and approaches that will be of value to researchers interested in ncRNA field.

Bioinformatics. --- Human genetics. --- Human Genetics. --- Computational Biology/Bioinformatics. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Data processing

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History of human medicine --- Immunology. Immunopathology --- immunologie --- farmacologie

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This book provides recent advances in the understanding of the central processes in the resolution of inflammation. It also describes the active, specialized pathways that bring the resolution of inflammation. Further, the book examines the key molecular and cellular events that are involved in the resolution of inflammation processes involved in tissue repair and regain of physiological function. Importantly, it sheds light on the cellular and molecular processes through which conventional inflammatory cytokines control mammalian tissue repair and regeneration. It also explores the perturbation of processes that are involved in the resolution of inflammation with aging and reviews clinical trials of anti-inflammatory and immunomodulatory therapies. Towards the end, the book discusses the role of inflammation in the development and progression of cancer. This book is an invaluable resource for scientists, academicians, and research scholars interested in the latest cutting-edge knowledge in the field of immunology, inflammation, inflammation resolution, and inflammatory diseases.

Immunology. --- Inflammation. --- Pharmacology. --- Diseases.