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Antiplatelet therapy is the cornerstone of treatment of ischemic cardiovascular disease and over the last few years spectacular advancements in this field have been recorded. This is the first comprehensive handbook entirely dedicated to all the aspects of antiplatelet therapy. The book is divided into three main sections, pathophysiology, pharmacology and therapy, for a total of 23 chapters. A large group of leading experts from different European countries and from the USA, both from academia and industry, have contributed to the book. Besides a detailed overview on the pharmacology and clinical applications of all the currently used or of the novel antiplatelet agents, innovative approaches (e.g. intracellular signalling as an antiplatelet target, small RNAs as platelet therapeutics, etc.) or unconventional aspects (e.g. pharmacologic modulation of the inflammatory action of platelets are also treated. The book is oriented to both basic investigators and to clinicians involved with research on platelet inhibition or with the clinical use of antiplatelet therapies.

Medicine. --- Molecular biology. --- Pharmacology. --- Internal medicine. --- Cardiology. --- Neurology. --- Biomedicine. --- Pharmacology/Toxicology. --- Internal Medicine. --- Molecular Medicine. --- Medicine --- Nervous system --- Neuropsychiatry --- Heart --- Internal medicine --- Medicine, Internal --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Diseases --- Physiological effect --- Blood platelets --- Cardiovascular system --- Aggregation. --- Diseases. --- Cardiovascular diseases --- Adhesiveness, Blood platelet --- Aggregation, Blood platelet --- Blood platelet aggregation --- Platelet adhesiveness --- Platelet aggregation --- Cell aggregation --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Health Workforce --- Neurology .

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A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of haematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.

Blood platelets --- Blood --- Cardiovascular system --- Blood Platelets --- Cardiovascular diseases --- Clinical hematology --- Hematologic diseases --- Hematology --- Platelets --- Thrombocytes --- Blood cells --- Megakaryocytes --- Diseases --- pathology --- Blood platelets. --- Diseases. --- Hematologic Diseases --- Cardiovascular Diseases --- Blood Platelet Disorders --- physiopathology

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Molecular biology --- Pharmacology. Therapy --- Pathology of the circulatory system --- Neuropathology --- Human medicine --- farmacologie --- geneeskunde --- hersenen --- toxicologie --- cardiologie --- moleculaire biologie

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This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.

Pharmacology. --- Hematology. --- Human physiology. --- Cardiology. --- Medicine --- Biology --- Human Physiology. --- Biomedical Research. --- Research.