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Quantification of the proliferative characteristics of normal and malignant cells has been of interest to oncolo­ gists and cancer biologists for almost three decades. This interest stems from (a) the fact that cancer is a disease of uncontrolled proliferation, (b) the finding that many of the commonly used anticancer agents are preferentially toxic to cells that are actively proliferating, and (c) the observa­ tion that significant differences in proliferation characteristics exist between normal and malignant cells. Initially, cell cycle analysis was pursued enthusiastically in the hope of gener­ ating information useful for the development of rational cancer therapy strategies; for example, by allowing identi­ fication of rapidly proliferating tumors against which cell cycle-specific agents could be used with maximum effec­ tiveness and by allowing rational scheduling of cell cyc- specific therapeutic agents to maximize the therapeutic ratio. Unfortunately, several difficulties have prevented realiza­ tion of the early promise of cell cycle analysis: Proliferative patterns of the normal and malignant tissues have been found to be substantially more complex than originally an­ ticipated, and synchronization of human tumors has proved remarkably difficult. Human tumors of the same type have proved highly variable, and the cytokinetic tools available for cell cycle analysis have been labor intensive, as well as somewhat subjective and in many cases inapplicable to humans. However, the potential for substantially improved cancer therapy remains if more accurate cytokinetic infor­ mation about human malignancies and normal tissues can be obtained in a timely fashion.

Flow cytometry --- Cell cycle --- Cancer cells --- Cell Cycle --- Cell Transformation, Neoplastic --- Flow Cytometry --- Cytophotometry --- Neoplastic Processes --- Cell Physiological Processes --- Neoplasms --- Fluorometry --- Cytological Techniques --- Cell Physiological Phenomena --- Pathologic Processes --- Pathological Conditions, Signs and Symptoms --- Clinical Laboratory Techniques --- Phenomena and Processes --- Diseases --- Luminescent Measurements --- Investigative Techniques --- Photometry --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemistry Techniques, Analytical --- Cytology --- Biology --- Health & Biological Sciences --- Growth --- Life sciences. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Biosciences --- Sciences, Life --- Science --- Cell cycle. --- Flow cytometry. --- Growth. --- Cell counting, Laser --- Cell separation, Laser --- Cell sorting, Laser --- Flow cytofluorometry --- Flow cytophotometry --- Laser cell counting --- Laser cell separation --- Laser cell sorting --- Cytometry --- Mitotic cycle --- Nuclear cycle (Cytology) --- Biological rhythms --- Cancer cell growth --- Cytology. --- FLOW CYTOMETRY --- TECHNIQUES --- CELL CYCLE --- TUMOR CELLS --- QUANTITATIVE ANALYSIS --- GROWTH

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Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology.

Neoplasms --- Molecular Targeted Therapy. --- Molecular Biology --- Molecular biology -- Methods. --- Molecular targeted therapy. --- Neoplasms -- Genetics. --- Neoplasms -- Pathology. --- Medicine --- Health & Biological Sciences --- Oncology --- genetics. --- pathology. --- methods. --- Targeted Molecular Therapy --- Molecular Targeted Therapies --- Molecular Therapy, Targeted --- Targeted Molecular Therapies --- Targeted Therapy, Molecular --- Therapy, Molecular Targeted --- Therapy, Targeted Molecular --- Molecular Targeted Therapy