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Because tumor necrosis factor-a (TNF-a) plays a pivotal role in the regulation of homeostasis and inflammatory immune responses, it offers valuable research opportunities to develop new drugs for the treatment of a wide range of disorders, including cancer, septic shock, rheumatoid arthritis, and other inflammatory diseases. In Tumor Necrosis Factor: Methods and Protocols, well-versed experimentalists survey the basic and translational research being conducted in this field and describe in detail the methods they have developed for TNF production, characterization, mutagenesis, and detection in biological specimens. They also provide several in vitro assays and animal models for studying the role of TNF in various TNF-related diseases and in cancer. The protocols presented follow the successful Methods in Molecular Medicine™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and highly practical, Tumor Necrosis Factor: Methods and Protocols offers molecular and cellular biologists, pharmacologists, and toxicologists a diverse set of productive, cutting-edge tools for illuminating the pathophysiological roles of TNF in disease and for identifying new drugs.

Oncology  . --- Oncology. --- Tumors --- Tumor necrosis factor --- Disease Models, Animal --- Receptors, Tumor Necrosis Factor --- Tumor Necrosis Factors --- TNF Receptor Ligands --- Tumor Necrosis Factor Superfamily Ligands --- Necrosis Factors, Tumor --- Receptor Ligands, TNF --- Receptors, Cachectin --- Receptors, TNF --- TNF Receptor --- Tumor Necrosis Factor Receptor --- Cachectin Receptors --- TNF Receptors --- Tumor Necrosis Factor Receptors --- Receptor, TNF --- Receptors, Death Domain --- Animal Disease Model --- Animal Disease Models --- Disease Model, Animal --- Animals, Laboratory --- Models, Biological --- Cachectin --- Lymphotoxin --- TNF (Immunology) --- Cytokines --- Glycoproteins --- Growth factors --- Macrophages

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Architectural drawing, Renaissance --- Architectural drawing --- Private collections --- 769.04:72 --- 741 <45> --- 76 <45> "15" --- 76 <45> "16" --- 091 <456.31> --- -Architectural drawing --- -Architectural drawing, Renaissance --- -#GOSA:IX.Arch.M --- 769 --- Renaissance architectural drawing --- Drawing, Architectural --- Plans --- Architectural design --- Communication in architectural design --- Drawing --- Mechanical drawing --- Prentenverzamelingen in de grafische kunsten. Iconografie. Iconologie-:-Architectuur. Bouwkunst --- Tekenkunst--Italië --- Grafische kunsten. Grafiek. Prentkunst--Italië--16e eeuw. Periode 1500-1599 --- Grafische kunsten. Grafiek. Prentkunst--Italië--17e eeuw. Periode 1600-1699 --- Handschriftenkunde. Handschriftencatalogi--Vaticaanstad. Kerkelijke Staat --- -Arts Prints --- Ghezzi, Pier Leone --- -Art collections --- Biblioteca apostolica caticana --- Biblioteca apostolica vaticana --- Apostolic Vatican Library --- BAV --- Biblioteca vaticana --- Bibliotheca Apostolica Vaticana --- Bibliotheca Vaticana --- Bibliothek des Vatikans --- Bibliothèque apostolique vaticane --- Bibliothèque du Vatican --- Bibliothèque vaticane --- Bybliotheca Vaticana --- Sifriyat ha-Ṿaṭiḳan --- Vatican Apostolic Library --- Vatican. --- Vatican City. --- Vatican Library --- Vatikanische Bibliothek --- Vatikanska apostolicheska biblioteka --- Vatikanska biblioteka --- Vatikanská knihovna --- ספריה האפוסטולית בואטיקו --- ספריית הוותיקן --- 091 <456.31> Handschriftenkunde. Handschriftencatalogi--Vaticaanstad. Kerkelijke Staat --- 76 <45> "16" Grafische kunsten. Grafiek. Prentkunst--Italië--17e eeuw. Periode 1600-1699 --- 76 <45> "15" Grafische kunsten. Grafiek. Prentkunst--Italië--16e eeuw. Periode 1500-1599 --- 741 <45> Tekenkunst--Italië --- 769.04:72 Prentenverzamelingen in de grafische kunsten. Iconografie. Iconologie-:-Architectuur. Bouwkunst --- #GOSA:IX.Arch.M --- Arts Prints --- Ghezzi, Pier Leone, --- Art collections --- Biblioteca apostolica vaticana. --- Architectural drawing, Renaissance - Italy - Catalogs. --- Architectural drawing - Italy - 16th century - Catalogs. --- Architectural drawing - Private collections - Vatican City - Catalogs. --- Architectural drawing - Vatican City - Catalogs. --- Dessins d'architecture --- Fonds speciaux --- Italie

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Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Cardiology. --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Heart --- Internal medicine --- Diseases --- Oxigen actiu --- Ús terapèutic --- Farmacologia --- Pharmacology. --- Clinical biochemistry. --- Neuroscience. --- Medical Biochemistry. --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Fotofarmacologia --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Toxicologia --- Medicaments --- Quimioteràpia --- Aplicacions mèdiques --- Aplicacions terapèutiques --- Ús en medecina --- Medicina alternativa --- Terapèutica --- Anions superòxid --- Oxigen reactiu --- Radicals d'oxigen --- Oxigen --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Immunology --- sepsis --- trauma --- multiple organ failure --- SIRS --- animal models --- translational studies --- clinical trials