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This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. Many adult onset neurodegenerative diseases appear to arise from the accumulation of misfolded, neurotoxic peptides. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.

Cellular signal transduction. --- Nervous system --Degeneration --Pathophysiology. --- Proteins --Physiological transport. --- Nervous system --- Proteins --- Cellular signal transduction --- Biological Transport --- Biochemical Processes --- Nervous System Diseases --- Cell Physiological Processes --- Biological Science Disciplines --- Diseases --- Natural Science Disciplines --- Chemical Processes --- Biochemical Phenomena --- Cell Physiological Phenomena --- Metabolism --- Chemical Phenomena --- Disciplines and Occupations --- Phenomena and Processes --- Metabolic Phenomena --- Protein Transport --- Physiology --- Signal Transduction --- Neurodegenerative Diseases --- Medicine --- Health & Biological Sciences --- Neurology --- Degeneration --- Pathophysiology --- Physiological transport --- Biological transport. --- Degeneration. --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Membrane transport --- Passive transport, Biological --- Transport, Biological --- Degeneration and regeneration --- Medicine. --- Neurosciences. --- Biomedicine. --- Degeneration (Pathology) --- Diffusion --- Osmosis --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences

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Neuropathology --- neurologie