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It is now well recognized that individualized cancer treatment planning, based on tumor characteristics specific to an individual's cancer, makes it easier to select those most likely to benefit from toxic cancer therapies and to avoid treating those least likely to benefit. In Biomarkers in Breast Cancer: Molecular Diagnostics for Predicting and Monitoring Therapeutic Effect, expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers, as well as examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines to the validation of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers. Authoritative and cutting-edge, Biomarkers in Breast Cancer: Molecular Diagnostics for Predicting and Monitoring Therapeutic Effect offers laboratory investigators developing new tumor markers, clinical investigators testing them, and clinicians using them an up-to-date understanding of both the prognostic/predictive indicators and the novel molecular-targeted therapies suitable for individualizing breast cancer therapy.

Breast Neoplasms --- Molecular Diagnostic Techniques. --- Tumor Markers, Biological. --- Breast --- Tumor markers. --- Sein --- Marqueurs tumoraux --- diagnosis. --- Cancer --- Molecular diagnosis. --- Prognosis. --- Pronostic --- Breast -- Cancer -- Molecular diagnosis. --- Breast -- Cancer -- Prognosis. --- Tumor markers --- Breast Diseases --- Clinical Laboratory Techniques --- Neoplasms by Site --- Genetic Techniques --- Investigative Techniques --- Skin Diseases --- Neoplasms --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Skin and Connective Tissue Diseases --- Molecular Diagnostic Techniques --- Medicine --- Health & Biological Sciences --- Oncology --- Molecular diagnosis --- Prognosis --- Biological markers (Oncology) --- Cancer markers --- Markers, Tumor --- Tumor associated markers --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biochemical markers --- Tumors