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Bryophytes --- Lichens --- Catalogs and collections --- Hult, Ragnar, --- López Seoane, Victor, --- Herbarium --- Catalogs.

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Nowadays, the battle against cancer is still an ongoing challenge, being one of the main evil characters of the modern world. Glioblastoma is one of them, the most common and aggressive brain cancer in adults for which there is no definite treatment yet, and its invasiveness gives the patients a very poor prognosis. From standard therapies to more targeted treatments, several of them have achieved to cross the bloodbrain barrier and showed promising pre-clinical results. Unfortunately, the effect of these therapies is not very specific, also affecting the healthy tissue and causing several side-effects in the patient. Antibodydrug conjugates (ADCs) are potent therapeutics with a targeted cytotoxic effect that comes from their binding specificity. ADCs are normally built with monospecific antibodies, binding to one type of antigen. However, the use of bispecific antibodies provides an even more targeted effect, by binding to two different antigens of the cell. In this thesis, a more targeted drug therapy for glioblastoma is aimed, with the use of ADCs. For that, an algorithm is proposed to find pairs of genes that co-express in high level in tumor tissue/cancer cells and in low level in healthy tissue/non-cancer cells. These gene pair candidates are also compared with individual genes to assess whether the use of bispecific ADCs would outperform the use of monospecific ADCs in order to achieve a higher drug targetting specificity.