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This addition to the Springer Brief in Stem Cells series focuses on aspects related to the specific mechanisms that ensure and control pluripotency and cell commitment in domestic animal species. This topic is generating rapidly-increasing interest due to the great potential for domestic animal species to be used as intermediate biomedical models, between the mouse and the human. The Brief addresses why we need large animal models for regenerative medicine. It also describes early embryo development with a careful and specific analysis of the regulatory mechanisms driving cleavage, polarization and genome activation in domestic species. How pluripotency is compartmentalized in domestic species as well as the different aspects that make the derivation of stem cells in domestic species very difficult are also addressed.

Biology --- Health & Biological Sciences --- Cytology --- Animal experimentation --- Medicine --- Animal models in research --- Research --- Life sciences. --- Reproductive medicine. --- Cell biology. --- Stem cells. --- Embryology. --- Life Sciences. --- Stem Cells. --- Cell Biology. --- Reproductive Medicine. --- Biological models --- Laboratory animals --- Cytology. --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Animal embryology --- Animals --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Embryos --- Reproduction --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Health aspects --- Embryology --- Development --- Health Workforce