Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Molecular biology --- Pharmacology. Therapy --- Oncology. Neoplasms --- tumoren --- farmacologie --- toxicologie --- oncologie --- moleculaire biologie

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Preface Tumor development and progression occur as a result of cumulative acquisition of genetic alterations affecting oncogenes and tumor suppressor genes. As a consequence of these alterations the arising tumor gains some fatal properties such as increased cell proliferation and decreased apoptosis, resulting in a net accumulation of tra- formed cells. Once a critical volume is achieved, lack of oxygen and nutrients limits further growth. To overcome this obstacle, the tumor cells initiate a program focused on the formation of new blood vessels within the host tissue. This process is termed tumor angiogenesis and contributes to the progression of most solid tumors and the formation of metastases. Since its discovery more than 30 years ago by Dr. Judah Folkman, tumor angiog- esis has been proposed as an ideal target for novel tumor therapies. Today the first anti-angiogenic compounds are available for the treatment of patients but their s- cess in the clinic is rather limited when given as monotherapies. This is in contrast to many preclinical results which revealed a much higher efficacy of these therapeutics in appropriate animal models. The reasons for this discrepancy are manifold, one being the existence of more than one angiogenic signaling system capable of driving tumor angiogenesis. Therefore it is no surprise that the inhibition of just one system is not sufficient to block the formation of new blood vessels in patients.

Neoplasms --- Angiogenesis Inhibitors --- Neoplasms --- Neovascularization, Pathologic --- Neovascularization inhibitors --- Tumors --- Neovascularization. --- Néovascularisation --- Tumeurs --- Néovascularisation --- drug therapy. --- therapeutic use. --- blood supply. --- drug therapy. --- Blood-vessels --- Inhibiteurs --- Vaisseaux sanguins --- EPUB-LIV-FT LIVMEDEC LIVSANTE SPRINGER-B

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

During the last 20 years it has become increasingly clear that the tumor micro-environment, the tumor stroma with its cellular end extracellular components, plays an crucial role in regulating tumor growth and progression. This book on Tumor-associated fibroblasts and their matrix  as part of the series on Tumor-Microenvironment  is the first comprehensive discussion of these two main players of the tumor microenvironment. The best experts in this new area of tumor research and therapy review the role of these major components in the tumor stroma in the process of tumor development and progression. They discuss their interaction with other players such as blood vessels and immune cells, and show novel perspectives for tumor therapy. This compilation of excellent contributions of the best known experts in this important field in cancer research and therapy is a must for all scientists engaged in basic and clinical research. Increasing evidence of successful targeting of both cellular and matrix components in tumor therapy renders this book of particular interest for scientists engaged in pharmaceutical industry searching for new components for cancer therapy.

Human biochemistry --- Oncology. Neoplasms --- tumoren --- medische biochemie --- biochemie --- oncologie