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This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis. .

Bile acids. --- Toxicology. --- Gastroenterology. --- Clinical medicine. --- Endocrinology. --- Pharmacology/Toxicology. --- Hepatology. --- Internal medicine --- Hormones --- Medicine, Clinical --- Medicine --- Digestive organs --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Diseases --- Toxicology --- Pharmacology. --- Gastroenterology . --- Endocrinology . --- Gastroenterology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Welcome to EVALITA 2020! EVALITA is the evaluation campaign of Natural Language Processing and Speech Tools for Italian. EVALITA is an initiative of the Italian Association for Computational Linguistics (AILC, http://www.ai-lc.it) and it is endorsed by the Italian Association for Artificial Intelligence (AIxIA, http://www.aixia.it) and the Italian Association for Speech Sciences (AISV, http://www.aisv.it).

Language & Linguistics --- EVALITA --- COVID-19 Infodemic --- linguistica computazionale --- Automatic Misogyny Identification --- Misogyny on Twitter Posts --- AlBERTo --- Convolutional Neural Network --- BERT Model --- Hate Speech Detection --- Multimodal Meme Detection --- MEME management --- Language Game ``La Ghigliottina'' --- Language Game ``La