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This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting Stem Cells and their potential for clinical application  which took place from August 23 - 25, 2006 in Kyiv and from August 26 - 31, 2006 in Simeiz, Ukraine. The meeting was devoted to hot topics  in Stem cell research such as Regulation of Haematopoietic and Non-haematopoietic Stem Cells, Clinical Application of Stem Cells, Preclinical Models and Gene Therapy. The editors are pleased that the original idea of a book could eventually be realised. This was made possible because of the willingness of many meeting participants to saddle themselves with the additional work of compiling their data and thoughts in form of an article for this edition. We are thus foremost grateful to all contributors for their valuable input. In accordance with the conference's main topics, the book is divided into five chapters - Haematopoietic stem cells and haematopoiesis , Biology of n- haematopoietic stem cells , Stem cells and malignancy , Cell processing; expansion and genetic modification  and Clinical haematopoietic stem cell transplantation .

Histology. Cytology --- Molecular biology --- Immunology. Immunopathology --- Oncology. Neoplasms --- Pathological haematology --- immunologie --- stamcellen --- oncologie --- hematologie --- cytologie --- histologie --- moleculaire biologie

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In the ‘Fifth Gene Technology Report’, renowned experts provide an overview of current developments and their applications in the dynamically evolving research field of gene and biotechnologies. They examine, among other topics, genetic diagnostics, somatic gene therapy, the development of vaccines, stem cell and organoid research, green gene technology, synthetic biology, gene drives, genome editing, epigenetics and single cell analysis. In addition to reporting on the current state of affairs in this field, the authors also discuss society’s perception of gene technologies and ethical and legal issues relating to them, such as genome edit-ing, cerebral organoids and big data in personalised medicine. Moreover, the interdisciplinary task force ‘Gentechnologiebericht’ (Gene Technology Report) offers recommendations on action that could be taken in relation to the key issues. With contributions by Karla Alex, Sina Bartfeld, Meik Bittkowski, Inge Broer, Lorina Buhr, Stephan Clemens, Wolfgang Van den Daele, Hans-Georg Dederer, Tobias J. Erb, Nina Gasparoni, Heiner Fangerau, Boris Fehse, Jürgen Hampel, Louise Herde, Ferdinand Hucho, Ali Jawaid, Aida Khachatryan, Sarah Kohler, Alma Kolleck, Martin Korte, Cordula Kropp, Alfons Labisch, Markus Lehmkuhl, Melanie Leidecker-Sandmann, Annette Leßmöllmann, Isabelle M. Mansuy, Lilian Marx-Stölting, Andreas Merk, Yannick Milhahn, Fruzsina Molnár-Gábor, Stefan Mundlos, Staffan Müller-Wille, Angela Osterheider, Anja Pichl, Barbara Prainsack, Jens Reich, Marlen Reinschke, Ortwin Renn, Hans-Jörg Rheinberger, Arnold Sauter, Hannah Schickl, Silke Schicktanz, Volker Stollorz, Constanze Störk-Biber, Jochen Taupitz, Jörn Walter, Eva C. Winkler, Martin Zenke and Michael M. Zwick. Im „Fünften Gentechnologiebericht“ bieten namhafte Expertinnen und Experten einen Überblick über aktuelle Entwicklungen des dynamischen Forschungsfeldes der Gen- und Biotechnologien und ihrer Anwendungen. In den Bick genommen werden u. a. genetische Diagnostik, somatische Gentherapie, Impfstoffentwicklung, Stammzell- und Organoidforschung, Grüne Gentechnik, Synthetische Biologie, Gene Drives, Genome-Editing, Epigenetik und Einzelzellanalyse. Neben Sachstandsberichten werden auch die gesellschaftliche Wahrnehmung der Gentechnologien sowie ethische und rechtliche Fragen erörtert, u. a. zu Genome-Editing, Hirnorganoiden und Big Data in der personalisierten Medizin. Die interdisziplinäre Arbeitsgruppe Gentechnologiebericht gibt außerdem Handlungsempfehlungen zu zentralen Themen. Mit Beiträgen von Karla Alex, Sina Bartfeld, Meik Bittkowski, Inge Broer, Lorina Buhr, Stephan Clemens, Wolfgang Van den Daele, Hans-Georg Dederer, Tobias J. Erb, Nina Gasparoni, Heiner Fangerau, Boris Fehse, Jürgen Hampel, Louise Herde, Ferdinand Hucho, Ali Jawaid, Aida Khachatryan, Sarah Kohler, Alma Kolleck, Martin Korte, Cordula Kropp, Alfons Labisch, Markus Lehmkuhl, Melanie Leidecker-Sandmann, Annette Leßmöllmann, Isabelle M. Mansuy, Lilian Marx-Stölting, Andreas Merk, Yannick Milhahn, Fruzsina Molnár-Gábor, Stefan Mundlos, Staffan Müller-Wille, Angela Osterheider, Anja Pichl, Barbara Prainsack, Jens Reich, Marlen Reinschke, Ortwin Renn, Hans-Jörg Rheinberger, Arnold Sauter, Hannah Schickl, Silke Schicktanz, Volker Stollorz, Constanze Störk-Biber, Jochen Taupitz, Jörn Walter, Eva C. Winkler, Martin Zenke und Michael M. Zwick.

MBP, KCQ, JFMG --- Biologie Ethik Forschung Gene Gesundheit Medizin Gentechnologie Grüne Gentechnik Synthetische Biologie Epigenetik Einzelzellanalyse Gene Drives Organoide Stammzellforschung Hirnorganoide Embryoide Datenschutz Monitoring Genbegriff Genom Gendeterminismus