Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.

Human genetics. --- Human Genetics. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Epidemiologia genètica --- Manuals de laboratori --- Protocols clínics --- Plans d'actuació mèdica --- Protocols en medicina --- Protocols de diagnòstic clínic --- Protocols mèdics --- Protocols terapèutics --- Medicina clínica --- Històries clíniques --- Protocols d'infermeria --- Tècniques de laboratori --- Epidemiologia molecular

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This volume presents state-of-the art design, analysis and integration approaches for biomedical data including novel statistical models for a comprehensive and powerful synthesis and assessment of scientific evidence. Chapters detail principles of systematic reviews, semi-automated tools for systematic searches, fixed- and random-effects meta-analytical models, living systematic reviews, meta-analysis of genetic studies, meta-analysis of pragmatic and explanatory trials, network meta-analysis, and other modern approaches for data synthesis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Meta- Research: Methods and Protocols book, written by global experts, will introduce the reader in a step-by-step process to the methods of the vital and highly promising field of evidence synthesis.

Life sciences. --- Bioinformatics. --- Life Sciences. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Biosciences --- Sciences, Life --- Science --- Data processing