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Troponin is a central subject in biochemical, biophysical, and physiological research. The discovery of this protein by Professor Setsuro Ebashi in 1965 initiated a new era in research into the molecular biology of the regulation of contraction in striated muscle. Troponin is one of the representative functional proteins in living organisms, and its structure and function have been studied extensively. Recently, the crystallographic structure of troponin ternary complex was determined successfully. Mutations in genes of cardiac isoforms of troponin have been shown to cause cardiomyopathies, an

Muscle contraction --- Regulation --- Contraction of muscles --- Muscles --- Contractility (Biology) --- Contraction --- Motility --- Human physiology. --- Biochemistry. --- Human Physiology. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Human biology --- Physiology --- Human body --- Composition

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The discovery of troponin by Professor Setsuro Ebashi opened a new era for research into the regulation of striated muscle contraction. This volume is the proceedings of the s- posium held at Okazaki, Japan, in 2005 celebrating the 40th anniversary of that discovery. Professor Ebashi started his work on muscle contraction when he was a young researcher, immediately after World War II, having been inspired by the book Chemistry of Muscular Contraction by Albert Szent-Györgyi. He was fascinated by the dynamic features of the contractile processes performed by the two contractile proteins, myosin and actin, in the presence of ATP. However, he wondered about the mechanism by which muscle relaxes after contraction. He proceeded with biochemical studies of muscle rel- ation and found in 1952 that a factor present in the supernatant of the suspension of minced frog skeletal muscle caused relaxation of glycerinated muscle ?bers. Based on this ?nding and succeeding work, he came to the conclusion that the relaxation of c- tracted muscle was caused by the uptake of calcium ions from the cytosol into the relaxing factor (sarcoplasmic reticulum). His work greatly contributed to elucidating the entire processes of excitation-contraction coupling, particularly the role of calcium ions in tr- gering the contractile response of myo?brils. Then he found that superprecipitation of actomyosin, i. e. , an in vitro contraction model, became sensitive to calcium ion concentration in the presence of a protein factor other than myosin and actin.

General biochemistry --- Human physiology --- biochemie --- fysiologie

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Animal biochemistry --- Animal physiology. Animal biophysics

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