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Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for regenerative medicine and drug screening. Bioreactor configurations are described, including their applications for stem cell expansion, and stem cell separation techniques such as isolation and purification are discussed. Basic definitions are provided concerning the different types of stem cells, from adult stem cells to the more recent induced pluripotent stem cells. The main characteristics of these different stem cell ty
Regenerative Medicine. --- Stem cells -- Research. --- Stem Cells. --- Stem cells --- Biotechnology --- Cytological Techniques --- Medicine --- Equipment and Supplies --- Investigative Techniques --- Cells --- Culture Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Anatomy --- Clinical Laboratory Techniques --- Health Occupations --- Technology --- Technology, Industry, and Agriculture --- Disciplines and Occupations --- Technology, Industry, Agriculture --- Bioreactors --- Cell Culture Techniques --- Stem Cells --- Regenerative Medicine --- Cell Separation --- Methods --- Biology --- Health & Biological Sciences --- Cytology --- Materials --- Stem cells. --- Materials. --- Chemical engineering --- Genetic engineering --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cell culture. --- Biotechnology.
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Tissue engineering. --- Regenerative medicine. --- Regenerative Medicine. --- Tissue Engineering. --- Engineering, Tissue --- Organ Culture Techniques --- Tissue Expansion --- Regenerative Medicine --- Guided Tissue Regeneration --- Cell- and Tissue-Based Therapy --- Medicine, Regenerative --- Medicines, Regenerative --- Regenerative Medicines --- Regenerative Endodontics --- Medicine --- Regeneration (Biology) --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Microphysiological Systems
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Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for regenerative medicine and drug screening. Bioreactor configurations are described, including their applications for stem cell expansion, and stem cell separation techniques such as isolation and purification are discussed. Basic definitions are provided concerning the different types of stem cells, from adult stem cells to the more recent induced pluripotent stem cells. The main characteristics of these different stem cell types are described, alongside the molecular mechanisms underlying their self-renewal and differentiation. The book also focuses on methodologies currently used for in vitro stem cell culture under static conditions, including the challenge of xeno-free culture conditions, as well as culture parameters that influence stem cell culture. Approaches for both stem cell culture and separation in micro-scale conditions are presented, including the use of cellular microarrays for high-throughput screening of the effect of both soluble and extracellular matrix molecules. A further section is dedicated to application of stem cells for regenerative medicine. Maintains a unique focus on both the basic stem cell biology concepts, and their translation to large-scale bioprocessing approachesEnvisages the use of stem cells in regenerative medicine and drug screening applicationsDiscusses the application of microscale techniques as a tool to perform basic stem cell biology studies.
Histology. Cytology --- Pharmacology. Therapy --- Human genetics --- Clinical chemistry
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Human genetics --- Clinical chemistry --- Stem cells. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells
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The next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is an immediate and long-term need for expertise with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realized. Specifically, there is a need for the development of bioprocess technology for the successful transfer of laboratory-based practice of stem cell and tissue culture to the clinic as therapeutics through the application of engineering principles and practices. This Special Issue of Bioengineering on Stem Cell Bioprocessing and Manufacturing addresses the central role in defining the engineering sciences of cell-based therapies, by bringing together contributions from worldwide experts on stem cell biology and engineering, bioreactor design and bioprocess development, scale-up, and manufacturing of stem cell-based therapies.
Medicine --- electrospinning --- live-cell electrospinning --- tissue engineering --- cell seeding --- high voltage --- viability --- allogeneic cell therapy --- induced pluripotent stem cell --- human embryonic stem cell --- cell aggregate --- expansion --- differentiation --- scalable manufacturing --- scale up --- single-use bioreactor --- Vertical-Wheel --- U-shaped vessel --- computational fluid dynamics --- shear stress --- turbulent energy dissipation rates --- homogeneous hydrodynamic environment --- human pluripotent stem cells --- hepatic cell lineages --- hepatocyte differentiation --- non-parenchymal liver cells --- liver organoids --- disease modeling --- drug screening --- olfactory ensheathing cells --- spinal cord injury --- neural regeneration --- cell therapies --- adipose stem cells --- neurotrophic factors --- growth factors --- peripheral nerve injuries --- fibrin nerve conduits --- hydrogels --- stem cells delivery --- axonal regeneration --- Schwann cells --- stromal vascular fraction --- stem cell --- adipose-derived stem cell --- infrapatellar fat pad --- knee --- arthroscopy --- arthrotomy --- bioreactor --- hMSCs --- microcarrier --- bioprocess --- embryonic stem cells --- mesenchymal stromal cells --- blood platelets --- cell culture techniques --- progenitor cells --- human adipose stem cells (hASCs) --- serum- and xeno-free conditions --- UrSuppe stem cell culture medium --- autologous therapy --- kinetic growth modeling --- segregated and unstructured growth model --- model predictive control --- bio-process --- cell growth --- lactate --- advanced therapy medicinal products --- n/a
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The next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is an immediate and long-term need for expertise with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realized. Specifically, there is a need for the development of bioprocess technology for the successful transfer of laboratory-based practice of stem cell and tissue culture to the clinic as therapeutics through the application of engineering principles and practices. This Special Issue of Bioengineering on Stem Cell Bioprocessing and Manufacturing addresses the central role in defining the engineering sciences of cell-based therapies, by bringing together contributions from worldwide experts on stem cell biology and engineering, bioreactor design and bioprocess development, scale-up, and manufacturing of stem cell-based therapies.
electrospinning --- live-cell electrospinning --- tissue engineering --- cell seeding --- high voltage --- viability --- allogeneic cell therapy --- induced pluripotent stem cell --- human embryonic stem cell --- cell aggregate --- expansion --- differentiation --- scalable manufacturing --- scale up --- single-use bioreactor --- Vertical-Wheel --- U-shaped vessel --- computational fluid dynamics --- shear stress --- turbulent energy dissipation rates --- homogeneous hydrodynamic environment --- human pluripotent stem cells --- hepatic cell lineages --- hepatocyte differentiation --- non-parenchymal liver cells --- liver organoids --- disease modeling --- drug screening --- olfactory ensheathing cells --- spinal cord injury --- neural regeneration --- cell therapies --- adipose stem cells --- neurotrophic factors --- growth factors --- peripheral nerve injuries --- fibrin nerve conduits --- hydrogels --- stem cells delivery --- axonal regeneration --- Schwann cells --- stromal vascular fraction --- stem cell --- adipose-derived stem cell --- infrapatellar fat pad --- knee --- arthroscopy --- arthrotomy --- bioreactor --- hMSCs --- microcarrier --- bioprocess --- embryonic stem cells --- mesenchymal stromal cells --- blood platelets --- cell culture techniques --- progenitor cells --- human adipose stem cells (hASCs) --- serum- and xeno-free conditions --- UrSuppe stem cell culture medium --- autologous therapy --- kinetic growth modeling --- segregated and unstructured growth model --- model predictive control --- bio-process --- cell growth --- lactate --- advanced therapy medicinal products --- n/a
Choose an application
The next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is an immediate and long-term need for expertise with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realized. Specifically, there is a need for the development of bioprocess technology for the successful transfer of laboratory-based practice of stem cell and tissue culture to the clinic as therapeutics through the application of engineering principles and practices. This Special Issue of Bioengineering on Stem Cell Bioprocessing and Manufacturing addresses the central role in defining the engineering sciences of cell-based therapies, by bringing together contributions from worldwide experts on stem cell biology and engineering, bioreactor design and bioprocess development, scale-up, and manufacturing of stem cell-based therapies.
Medicine --- electrospinning --- live-cell electrospinning --- tissue engineering --- cell seeding --- high voltage --- viability --- allogeneic cell therapy --- induced pluripotent stem cell --- human embryonic stem cell --- cell aggregate --- expansion --- differentiation --- scalable manufacturing --- scale up --- single-use bioreactor --- Vertical-Wheel --- U-shaped vessel --- computational fluid dynamics --- shear stress --- turbulent energy dissipation rates --- homogeneous hydrodynamic environment --- human pluripotent stem cells --- hepatic cell lineages --- hepatocyte differentiation --- non-parenchymal liver cells --- liver organoids --- disease modeling --- drug screening --- olfactory ensheathing cells --- spinal cord injury --- neural regeneration --- cell therapies --- adipose stem cells --- neurotrophic factors --- growth factors --- peripheral nerve injuries --- fibrin nerve conduits --- hydrogels --- stem cells delivery --- axonal regeneration --- Schwann cells --- stromal vascular fraction --- stem cell --- adipose-derived stem cell --- infrapatellar fat pad --- knee --- arthroscopy --- arthrotomy --- bioreactor --- hMSCs --- microcarrier --- bioprocess --- embryonic stem cells --- mesenchymal stromal cells --- blood platelets --- cell culture techniques --- progenitor cells --- human adipose stem cells (hASCs) --- serum- and xeno-free conditions --- UrSuppe stem cell culture medium --- autologous therapy --- kinetic growth modeling --- segregated and unstructured growth model --- model predictive control --- bio-process --- cell growth --- lactate --- advanced therapy medicinal products --- electrospinning --- live-cell electrospinning --- tissue engineering --- cell seeding --- high voltage --- viability --- allogeneic cell therapy --- induced pluripotent stem cell --- human embryonic stem cell --- cell aggregate --- expansion --- differentiation --- scalable manufacturing --- scale up --- single-use bioreactor --- Vertical-Wheel --- U-shaped vessel --- computational fluid dynamics --- shear stress --- turbulent energy dissipation rates --- homogeneous hydrodynamic environment --- human pluripotent stem cells --- hepatic cell lineages --- hepatocyte differentiation --- non-parenchymal liver cells --- liver organoids --- disease modeling --- drug screening --- olfactory ensheathing cells --- spinal cord injury --- neural regeneration --- cell therapies --- adipose stem cells --- neurotrophic factors --- growth factors --- peripheral nerve injuries --- fibrin nerve conduits --- hydrogels --- stem cells delivery --- axonal regeneration --- Schwann cells --- stromal vascular fraction --- stem cell --- adipose-derived stem cell --- infrapatellar fat pad --- knee --- arthroscopy --- arthrotomy --- bioreactor --- hMSCs --- microcarrier --- bioprocess --- embryonic stem cells --- mesenchymal stromal cells --- blood platelets --- cell culture techniques --- progenitor cells --- human adipose stem cells (hASCs) --- serum- and xeno-free conditions --- UrSuppe stem cell culture medium --- autologous therapy --- kinetic growth modeling --- segregated and unstructured growth model --- model predictive control --- bio-process --- cell growth --- lactate --- advanced therapy medicinal products
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