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Over the years, India has attained a prominent global position in the manufacture of Generic Drugs. This success can be attributed to its synthetic organic chemistry and chemical engineering strengths, nurtured by the timely policies of the Government of India. However, breakthrough successes in New Drug Discovery have remained elusive, despite the brilliant and sustained efforts of many Indian researchers and Pharma establishments. The Indian National Science Academy thought it appropriate to document India’s New Drug Discovery Research (NDDR) journey to date. Gathering contributions from prominent researchers in the Indian Pharma Industry and Academia, this book highlights their efforts, achievements, and the status quo of Indian NDDR. .

Pharmacology. --- Biotechnology. --- Medicine. --- Pharmacology/Toxicology. --- Biomedicine, general. --- Health Workforce --- Chemical engineering --- Genetic engineering --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Drug development --- Development of drugs --- New drug development --- Pharmacology --- Development

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History of human medicine --- Toxicology --- Biotechnology --- farmacologie --- multimedia --- biotechnologie

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This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Cell biology. --- Cardiology. --- Biochemistry. --- Biomedical engineering. --- Health promotion. --- Cell physiology. --- Cell Biology. --- Biochemistry, general. --- Biomedical Engineering/Biotechnology. --- Health Promotion and Disease Prevention. --- Cell Physiology. --- Cell function --- Cytology --- Physiology --- Health promotion programs --- Health promotion services --- Promotion of health --- Wellness programs --- Preventive health services --- Health education --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Heart --- Internal medicine --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Diseases --- Active oxygen. --- Molecular aspects. --- Oxygen radicals --- Reactive oxygen --- Singlet oxygen --- Superperoxide anion --- Free radicals (Chemistry) --- Ionization of gases --- Oxygen --- Estrès oxidatiu --- Malalties del cor --- Cytology.

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