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Apoptosis --- Apoptosis

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The content of this book gives a multi-disciplinary approach into the anti-cancer research field related to natural products and dietary compounds. Mainly, it covers the area of antitumor activity through an in-depth description of the cytotoxic, anti-inflammatory and anti-oxidant properties in cancer, inflammatory and cardio-vascular diseases. The cell death inducing mechanisms (apoptosis, anti-proliferative activity, angiogenesis, cell cycle control, cytostatic property and autophagy) give an overview of how natural products are able to target cancer cells.

Cancer -- Treatment. --- Cancer. --- Critical care medicine. --- Cell Physiological Processes --- Complex Mixtures --- Cell Physiological Phenomena --- Chemicals and Drugs --- Phenomena and Processes --- Cell Death --- Biological Products --- Cell death. --- Organic compounds. --- Compounds, Organic --- Organic chemicals --- Cell degeneration --- Medicine. --- Biomedicine. --- Biomedicine general. --- Carbon compounds --- Cells --- Death (Biology) --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.

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Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, "Marine Natural Products as Anticancer Agents 2.0", gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.

Antineoplastic agents

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Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment.

alga --- marine-derived fungus --- Penicillium chrysogenum --- polyketide --- hydroxyphenylacetic acid --- cytotoxicity --- flaccidoxide-13-acetate --- hepatocellular carcinoma --- invasion --- migration --- epithelial-mesenchymal transition --- prostate cancer --- astaxanthin --- STAT3 --- proliferation --- colony formation --- apoptosis --- Sarcophyton digitatum --- biscembranoid-type metabolites --- inflammatory factor production --- LPS-stimulated murine macrophage --- Ehlich’s tumor --- P. purpurogenum --- antitumor --- meroterpenoids --- inflammation --- T47D --- BT20 --- pontin --- mutp53 --- cancer stem cells --- Oct4 --- Nanog --- siRNA --- secondary metabolites --- epigenome --- epigenetic signaling --- bioactive compounds --- cancer therapy --- marine species --- environment --- total synthesis --- natural product --- nannocystin --- anti-cancer --- gram-scale --- aplysinopsin analogs --- indole alkaloids --- marine source --- chronic myeloid leukemia --- BH3 mimetics --- n/a --- Ehlich's tumor

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Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment.

Medicine --- alga --- marine-derived fungus --- Penicillium chrysogenum --- polyketide --- hydroxyphenylacetic acid --- cytotoxicity --- flaccidoxide-13-acetate --- hepatocellular carcinoma --- invasion --- migration --- epithelial-mesenchymal transition --- prostate cancer --- astaxanthin --- STAT3 --- proliferation --- colony formation --- apoptosis --- Sarcophyton digitatum --- biscembranoid-type metabolites --- inflammatory factor production --- LPS-stimulated murine macrophage --- Ehlich's tumor --- P. purpurogenum --- antitumor --- meroterpenoids --- inflammation --- T47D --- BT20 --- pontin --- mutp53 --- cancer stem cells --- Oct4 --- Nanog --- siRNA --- secondary metabolites --- epigenome --- epigenetic signaling --- bioactive compounds --- cancer therapy --- marine species --- environment --- total synthesis --- natural product --- nannocystin --- anti-cancer --- gram-scale --- aplysinopsin analogs --- indole alkaloids --- marine source --- chronic myeloid leukemia --- BH3 mimetics --- alga --- marine-derived fungus --- Penicillium chrysogenum --- polyketide --- hydroxyphenylacetic acid --- cytotoxicity --- flaccidoxide-13-acetate --- hepatocellular carcinoma --- invasion --- migration --- epithelial-mesenchymal transition --- prostate cancer --- astaxanthin --- STAT3 --- proliferation --- colony formation --- apoptosis --- Sarcophyton digitatum --- biscembranoid-type metabolites --- inflammatory factor production --- LPS-stimulated murine macrophage --- Ehlich's tumor --- P. purpurogenum --- antitumor --- meroterpenoids --- inflammation --- T47D --- BT20 --- pontin --- mutp53 --- cancer stem cells --- Oct4 --- Nanog --- siRNA --- secondary metabolites --- epigenome --- epigenetic signaling --- bioactive compounds --- cancer therapy --- marine species --- environment --- total synthesis --- natural product --- nannocystin --- anti-cancer --- gram-scale --- aplysinopsin analogs --- indole alkaloids --- marine source --- chronic myeloid leukemia --- BH3 mimetics