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This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of metabolism and toxicological effects by organ system/developmental stage, and aspects of PFAS toxicity that are driving PFAS research and regulatory oversight. Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances provides critical assessments of the most controversial topics surrounding toxicological evaluation of PFASs to give readers an expert perspective on the issues. Emphasis is placed on the integration of modes and mechanisms of action with functional endpoints that are relevant to human and wildlife health. This book will be a useful resource for toxicologists, environmental chemists, risk assessors, and researchers with an interest in the class of compounds known as perfluoroalkyl and polyfluoroalkyl substances.

Biomedicine. --- Pharmacology/Toxicology. --- Environmental Health. --- Ecotoxicology. --- Medicine. --- Toxicology. --- Environmental Medicine. --- Environmental toxicology. --- Médecine --- Toxicologie --- Ecotoxicologie --- Fluorocarbons -- Toxicology. --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Pharmacology. --- Environmental health. --- Ecotoxicology --- Pollutants --- Pollution --- Environmental health --- Toxicology --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Environmental quality --- Health --- Health ecology --- Public health --- Environmental engineering --- Health risk assessment --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Health aspects --- Environmental aspects --- Physiological effect

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This fully updated volume utilizes the expertise of scientists currently engaged in immunotoxicity testing to provide the reader with lab-ready procedures and the background information needed to identify effective testing approaches. Dedicated to identifying and describing exogenous agents that can modify immune function, uncovering modes and mechanisms of action for such agents, and translating data from the laboratory and from the clinic to better predict health risks as well as benefits to those who are exposed to immunomodulatory agents, immunotoxicity testing continues to be a vital field of study, and this collection highlights both the “tried and true” methods as well as alternative protocols that have been more recently developed. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immunotoxicity Testing: Methods and Protocols, Second Edition serves as a valuable contribution to the continued evolution and the application of immunotoxicity testing.

Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Immunotoxicologia --- Manuals de laboratori --- Protocols clínics --- Immunotoxicitat --- Toxicologia immunològica --- Immunopatologia --- Toxicologia --- Immunofarmacologia --- Plans d'actuació mèdica --- Protocols en medicina --- Protocols de diagnòstic clínic --- Protocols mèdics --- Protocols terapèutics --- Medicina clínica --- Històries clíniques --- Protocols d'infermeria --- Tècniques de laboratori