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Book
Year: 1997 Publisher: Gent Graduaat in het bibliotheekwezen en de documentaire informatiekunde
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Library management --- Information user --- Library automation --- Museology --- Computer architecture. Operating systems --- Royal Museum of Fine Arts [Antwerp]
Book
Year: 1933 Publisher: Bruxelles Naturalistes belges
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Book
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Book
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Dissertation
Year: 2019 Publisher: Leuven KU Leuven. Faculty of Medicine
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Overwhelming epidemiological evidence shows that diabetes mellitus is independently associated with heart failure incidence, with the risk being increased by more than twofold in men and by more than fivefold in women. The most prevalent phenotype of heart failure in patients with obesity and diabetes mellitus is heart failure with preserved ejection fraction (HFpEF) (ejection fraction ≥50%)2. Inflammation has been proposed to be the primary pathophysiological driver of HFpEF, whereas cardiomyocyte loss and stretch are the principal drivers of heart failure with reduced ejection fraction (HFrEF) (ejection fraction ≤40%). Diabetic cardiomyopathy was first described in 1972 and is characterized by the existence of ventricular dysfunction in the absence of other cardiac risk factors, such as coronary artery disease, hypertension, and significant valvular disease, in individuals with diabetes mellitus. In this PhD thesis, hard evidence is provided that cholesterol lowering gene therapy prevents HFpEF in a model of high sugar-high fat (HSHF) diet-induced diabetic cardiomyopathy. Furthermore, infusion of reconstituted HDLMilano reverses established heart failure in mice with HSHF diet-induced diabetic cardiomyopathy.
Dissertation
Year: 2023 Publisher: Leuven KU Leuven. Faculteit Geneeskunde
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Heart failure is the cardiovascular epidemic of the 21st century. The ejection fraction has a bimodal distribution among patients with incident heart failure. A distinction is made between heart failure with reduced ejection fraction (HFrEF) (ejection fraction ≤40%), heart failure with mid-range or mildly reduced ejection fraction (40.1%-49.9%) (HFmrEF), and heart failure with preserved ejection (HFpEF) (ejection fraction ≥ 50%). The introduction of sodium-glucose cotransporter-2 (SGLT2) inhibitors in heart failure management has been regarded by many as a significant advance, in particular in the treatment of HFpEF. The primary outcome measure in definitive phase III clinical trials should be a clinical event relevant to the patient or an endpoint that measures directly how a patient feels, functions or survives, where function refers to patients’ ability to perform activities in their daily lives. The application of this definition in the field of heart failure is complex. The major goals of heart failure treatment have been categorized as: (1) reduction in (cardiovascular) mortality, (2) prevention of recurrent hospitalizations due to worsening heart failure, and (3) improvement in clinical status, functional capacity, and quality of life. The use of the composite primary endpoint of cardiovascular death and hospitalization for heart failure in SGLT2 inhibitor HFpEF trials was not justified since the effect of the intervention on both components was clearly distinct. Moreover, the lack of convincing and clinically meaningful effects of SGLT2 inhibitors on metrics of heart failure-related health status indicates that the effect of this class of drugs in HFpEF patients is essentially restricted to an effect on hospitalization for heart failure. In conclusion, SGLT2 inhibitors do not represent a major breakthrough in the management of HFpEF.
Dissertation
Year: 2013 Publisher: Leuven KU Leuven
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Dissertation
Year: 2005 Publisher: Leuven K.U.Leuven. Faculteit Geneeskunde
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Dissertation
Year: 2011 Publisher: Leuven KUL. Faculteit geneeskunde
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Dissertation
Year: 2007 Publisher: Leuven K.U.Leuven. Faculteit Geneeskunde
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