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Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals is a comprehensive handbook on all aspects of adverse effects by drugs and chemical substances on the kidneys. The importance of the toxicity of drugs and other substances for the kidneys is increasingly recognized. The first, general part deals with themes as clinical relevance, renal handling, pharmacovigilance, urinary biomarkers, pharmacological, immunological and cellular aspects of nephrotoxicity, as well as animal and cell culture models. The second part includes the specific drugs; the third part gives the description of environmental and occupational nephrotoxins. The last part deals with the patient with some degree of renal failure, exposed to drugs and chemicals, the progression of renal disease, and how to adapt drug dosage. In this third and completely revised edition, nine new chapters were added, from proton pump inhibitors to bisphosphonates, phosphate containing laxatives, oxalate, star fruit and smoking. All chapters were extended with up-to-date references. The book is of interest for the nephrologist, internist, general practitioner, toxicologist, pharmacologist, anesthesiologist, epidemiologist, public health official, pharmaceutical industry, and national drug safety committees, among others.

Nephrotoxicology. --- Renal pharmacology. --- Kidneys --- Kidneys, Effect of drugs on --- Pharmacology --- Kidney toxicity --- Kidney toxicology --- Nephrotoxic disease --- Nephrotoxicity --- Renal toxicity --- Renal toxicology --- Toxicology --- Drug effects --- Effect of drugs on --- Diseases --- Nephrology. --- Internal medicine. --- Internal Medicine. --- Medicine, Internal --- Medicine --- Internal medicine

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GEORGE A. PORTER information is an international commodity whose The field of clinical nephrotoxicity involves toxins of interpretation and application are strongly influenced diverse origin and exposure. A significant contribution by both the cultural and ethnic background of the to this problem arises from registered and non-regis­ observer. The opportunity to share in the rich diversity tered drugs either prescribed or purchased over the of the international scientific community was a fun­ counter. Another major contributor comes from occu­ pational or industrial exposures. Each situation pre­ damental goal of this endeavor. To participate as sents the nephrologist with unique challenges con­ equals leads to mutual respect and peer appreciation. cerning diagnosis, confirrnation, and treatment includ­ The sharing of intellectual resources which such an ing limitation from future exposure. In selecting drugs effort fosters, should facilitate the advancement of for inclusions in this book the editors were guided by sound science. both frequency and current knowledge. For occupa­ Our approach to the field of nephrotoxicity is from tionall environmental exposures similar guidelines the perspective of a book which will be of value to the were applied. As one reviews the world's literature clinician. In this respect we have chosen compounds concerning nephrotoxicity two types of investigation wh ich are of current importance to the nephrologist and his/her patient rather than of historical interest.

Kidney toxicity --- Kidney toxicology --- Nefrotoxicologie --- Nephrotoxic disease --- Nephrotoxicity --- Nephrotoxicology --- Néphrotoxicologie --- Renal toxicity --- Renal toxicology --- Toxicologie [Nefro] --- Toxicologie [Néphro] --- Kidneys --- Effect of drugs on --- Nephrology. --- Internal medicine. --- Pharmacology. --- Internal Medicine. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Medicine, Internal --- Medicine --- Internal medicine --- Physiological effect --- Nephrotoxicology. --- Toxicology --- Diseases --- KIDNEY --- KIDNEY DISEASES --- DRUG EFFECTS --- CHEMICALLY INDUCED

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Pure sciences. Natural sciences (general)