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Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals is a comprehensive handbook on all aspects of adverse effects by drugs and chemical substances on the kidneys. The importance of the toxicity of drugs and other substances for the kidneys is increasingly recognized. The first, general part deals with themes as clinical relevance, renal handling, pharmacovigilance, urinary biomarkers, pharmacological, immunological and cellular aspects of nephrotoxicity, as well as animal and cell culture models. The second part includes the specific drugs; the third part gives the description of environmental and occupational nephrotoxins. The last part deals with the patient with some degree of renal failure, exposed to drugs and chemicals, the progression of renal disease, and how to adapt drug dosage. In this third and completely revised edition, nine new chapters were added, from proton pump inhibitors to bisphosphonates, phosphate containing laxatives, oxalate, star fruit and smoking. All chapters were extended with up-to-date references. The book is of interest for the nephrologist, internist, general practitioner, toxicologist, pharmacologist, anesthesiologist, epidemiologist, public health official, pharmaceutical industry, and national drug safety committees, among others.
Nephrotoxicology. --- Renal pharmacology. --- Kidneys --- Kidneys, Effect of drugs on --- Pharmacology --- Kidney toxicity --- Kidney toxicology --- Nephrotoxic disease --- Nephrotoxicity --- Renal toxicity --- Renal toxicology --- Toxicology --- Drug effects --- Effect of drugs on --- Diseases --- Nephrology. --- Internal medicine. --- Internal Medicine. --- Medicine, Internal --- Medicine --- Internal medicine
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To you the reader, the joy of discovery begins, for We continue in our goal of providing a text which us the job is done. In this edition, we have corrected is useful, not only to the clinician, but of equal interest past deficiencies, added new topics, expanded infor- to the investigator. The selection of content has been mation regarding the pediatric age group, provided directed at topics of current interest rather than those up to date (March 2003) references, while remaining of historic contribution. We have stressed the cont- true to our concept of a multi-national author book. bution of cell biology and pathophysiology, were it We continue to believe that scientific information is an exists, believing it provides both a better understa- international commodity whose interpretation and ap- ing of toxic injury when known, and a rational dir- plication are strongly influenced by both the cultural tion for therapy and prevention. and ethnic background of the observer. The oppor- nity to share in the rich diversity of the international We are encouraged by the accumulation of rec- scientific community remains a fundamental goal of nized risk factors, which allow pre-treatment strati- this endeavor. To participate as equals leads to mu- cation of our patients’ relative risk and allow us to - tual respect and peer appreciation. The sharing of in- cus our preventative techniques on the individuals tellectual resources fostered by this effort should and most likely to gain the greatest benefit.
Nefrology --- Kidney --- Kidney Diseases --- Nephrotoxicology. --- Renal pharmacology. --- Néphrotoxicité --- drug effects. --- chemically induced. --- Internal medicine. --- Kidneys - Effect of drugs on. --- Medicine. --- Nephrology. --- Veterinary medicine. --- Nephrotoxicology --- Kidneys --- Urologic Diseases --- Urinary Tract --- Male Urogenital Diseases --- Female Urogenital Diseases --- Urogenital System --- Diseases --- Anatomy --- Female Urogenital Diseases and Pregnancy Complications --- Medicine --- Health & Biological Sciences --- Urology & Nephrology --- Effect of drugs on --- Public health. --- Medicine & Public Health. --- Veterinary Medicine. --- Internal Medicine. --- Public Health. --- Veterinary Medicine/Veterinary Science. --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Social hygiene --- Health --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation --- Medicine, Internal --- Farriery --- Large animal medicine --- Large animal veterinary medicine --- Livestock medicine --- Veterinary science --- Animal health --- Animals --- Domestic animals --- Livestock --- Internal medicine --- Losses --- drug effects --- chemically induced
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GEORGE A. PORTER information is an international commodity whose The field of clinical nephrotoxicity involves toxins of interpretation and application are strongly influenced diverse origin and exposure. A significant contribution by both the cultural and ethnic background of the to this problem arises from registered and non-regis observer. The opportunity to share in the rich diversity tered drugs either prescribed or purchased over the of the international scientific community was a fun counter. Another major contributor comes from occu pational or industrial exposures. Each situation pre damental goal of this endeavor. To participate as sents the nephrologist with unique challenges con equals leads to mutual respect and peer appreciation. cerning diagnosis, confirrnation, and treatment includ The sharing of intellectual resources which such an ing limitation from future exposure. In selecting drugs effort fosters, should facilitate the advancement of for inclusions in this book the editors were guided by sound science. both frequency and current knowledge. For occupa Our approach to the field of nephrotoxicity is from tionall environmental exposures similar guidelines the perspective of a book which will be of value to the were applied. As one reviews the world's literature clinician. In this respect we have chosen compounds concerning nephrotoxicity two types of investigation wh ich are of current importance to the nephrologist and his/her patient rather than of historical interest.
Kidney toxicity --- Kidney toxicology --- Nefrotoxicologie --- Nephrotoxic disease --- Nephrotoxicity --- Nephrotoxicology --- Néphrotoxicologie --- Renal toxicity --- Renal toxicology --- Toxicologie [Nefro] --- Toxicologie [Néphro] --- Kidneys --- Effect of drugs on --- Nephrology. --- Internal medicine. --- Pharmacology. --- Internal Medicine. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Medicine, Internal --- Medicine --- Internal medicine --- Physiological effect --- Nephrotoxicology. --- Toxicology --- Diseases --- KIDNEY --- KIDNEY DISEASES --- DRUG EFFECTS --- CHEMICALLY INDUCED
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