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Aegean Conferences is an independent, nonprofit, educational organization directed and managed by the scientific community. The board is made up of nine researchers/scientists in various disciplines from Harvard, Brown, University of Pennsylvania, UCSD, Princeton, Biovista and the Foundation for Biomedical Research Academy of Athens. The board both invites and approves unsolicited proposals for Conferences in all fields of Science, Engineering, Arts, and Humanities. The purpose of the Conferences is to bring together individuals with common interests to examine the emerging and most advanced aspects of their particular field. This volume will include mini-reviews derived from work to be presented at the Aegean Conference: Second Crossroads between Innate and Adaptive Immunity, in Crete, Greece, June 17-22, 2007. This meeting is designed to serve as a forum to discuss the most recent progress in complement research as it pertains to human disease pathogenesis and therapeutics. The rapid pace of development in complement basic research and the advent and application of new experimental approaches in this field have now allowed us to take an integrated view of the in vivo biology of the complement system. The availability of new reagents (e.g. synthetic and recombinant inhibitors) and animal models (e.g. transgenic and knockout mice) has enabled us to address, in an in vivo setting, its involvement in various pathophysiological conditions. Such studies are shedding new light on the pathogenetic mechanism of complement-related diseases such as autoimmune diseases and inflammatory tissue damage as well as defining new areas of high interest such as the developmental biology of complement. They also provide the basis for developing new therapeutic strategies for these diseases through manipulation of in vivo complement activity. This volume will serve as a resource where the latest development in these specific areas will be discussed in a more focused and detailed manner.

Immune response --Regulation --Congresses. --- Natural immunity --Congresses. --- Natural immunity --- Immune response --- Biological Science Disciplines --- Immunity --- Immune System Processes --- Adaptive Immunity --- Publication Formats --- Immunity, Cellular --- Publication Characteristics --- Immune System Phenomena --- Natural Science Disciplines --- Disciplines and Occupations --- Phenomena and Processes --- Immunity, Innate --- Physiology --- Antigen Presentation --- Immunity, Active --- Congresses --- Medicine --- Biology --- Health & Biological Sciences --- Medical Research --- Microbiology & Immunology --- Regulation --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Medicine. --- Immunology. --- Pharmacology. --- Infectious diseases. --- Biochemistry. --- Microbiology. --- Biomedicine. --- Infectious Diseases. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Microbial biology --- Microorganisms --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Composition --- Physiological effect --- Emerging infectious diseases. --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Toxicology

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This volume presents a collection of reviews derived from work presented at the Aegean Conference: “3rd Crossroads between innate and adaptive immunity” which occurred during September 27 - October 2, 2009 at the Minoa Palace Conference Center in Chania, Crete, Greece. This meeting was the third in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The various facets of the innate response, including dendritic cells, T cells, B cells, NK cells, NK-T cells and the complement cascade during the host response to pathogens and tumors is only now starting to be elucidated.  The respective fields that focus on these immune cells and molecules have tended to be relatively compartmentalized, and yet emerging evidence points to the interconnectedness of these facets in coordinating the innate response, and its subsequent impact on the adaptive response.  The goal of this conference was to initiate cross-talk between these diverse immunological fields, and promote and facilitate discussion on the interactions between the innate immune response and the adaptive immune response and ultimately facilitate collaboration between these areas of study. Following on the footsteps of the outstanding success of its precursors, the  “3rd Crossroads between Innate and Adaptive Immunity” Aegean Conference was highly successful in bringing together and connecting scientists and experts from around the world to address critical areas of Innate and Adaptive immunity.

Immunity -- Congresses. --- Immunology -- Congresses. --- Natural immunity -- Congresses. --- Natural immunity --- Immune response --- Lymphocytes --- Biological Science Disciplines --- Diseases --- Immune System Phenomena --- Publication Formats --- Adaptive Immunity --- Natural Science Disciplines --- Phenomena and Processes --- Publication Characteristics --- Leukocytes, Mononuclear --- Leukocytes --- Disciplines and Occupations --- Immune System --- Blood Cells --- Blood --- Cells --- Hemic and Immune Systems --- Anatomy --- T-Lymphocytes --- Immunity, Innate --- Congresses --- Physiology --- Immunity, Active --- Immunity --- Neoplasms --- Medicine --- Biology --- Health & Biological Sciences --- Medical Research --- Microbiology & Immunology --- Regulation --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Medicine. --- Immunology. --- Pharmacology. --- Infectious diseases. --- Biochemistry. --- Microbiology. --- Biomedicine. --- Infectious Diseases. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Microbial biology --- Microorganisms --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Composition --- Physiological effect --- Emerging infectious diseases. --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Toxicology