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This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.  .

Influenza. --- Flu --- Flu, Respiratory --- Grippe --- Respiratory flu --- Respiratory infections --- Virus diseases --- Medical virology. --- Immunology. --- Emerging infectious diseases. --- Medicine. --- Virology. --- Infectious Diseases. --- Health Promotion and Disease Prevention. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Immunobiology --- Serology --- Medical microbiology --- Virology --- Health Workforce --- Infectious diseases. --- Health promotion. --- Health promotion programs --- Health promotion services --- Promotion of health --- Wellness programs --- Preventive health services --- Health education --- Microbiology

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Recent years have seen unprecedented outbreaks of avian influenza A viruses. In particular, highly pathogenic H5N1 viruses have not only resulted in widespread outbreaks in domestic poultry, but have been transmitted to humans resulting in numerous fatalities. The rapid expansion in their geographic distribution and the possibility that these viruses could acquire the ability to spread from person to person raise the risk that such a virus could cause a global pandemic with high morbidity and mortality. An effective influenza vaccine represents the best approach to prevent and control such an emerging pandemic. However, current influenza vaccines are directed at existing seasonal influenza viruses, which have limited antigenic relationships to the highly pathogenic H5N1 strains. Concerns about pandemic preparedness have greatly stimulated research activities to develop effective vaccines for pandemic influenza viruses, and to overcome the limitations inherent in current approaches to vaccine production and distribution. These limitations include the use of embryonated chicken eggs as the substrate for vaccine production; which is time-consuming and could involve potential biohazards in growth of new virus strains. Other limitations include the requirement that the current inactivated influenza vaccines be administered using needles and syringes, requiring trained personnel, which could be a bottleneck when attempting to vaccinate large populations in mass campaigns. In addition, the current inactivated vaccines which are delivered by injection elicit limited protective immunity in the upper respiratory tract where the infection process is initiated. Most of these limitations of the current vaccines are being addressed by research on novel approaches to vaccine development and delivery that are described in many of the chapters in this volume.

Disease Outbreaks. --- Influenza vaccines. --- Influenza Vaccines -- therapeutic use. --- Influenza, Human. --- Influenzavirus A. --- Influenza Vaccines --- Influenzavirus A --- Influenza, Human --- Disease Outbreaks --- Orthomyxoviridae --- Viral Vaccines --- Public Health --- Orthomyxoviridae Infections --- Respiratory Tract Infections --- Environment and Public Health --- RNA Viruses --- Vaccines --- Respiratory Tract Diseases --- RNA Virus Infections --- Diseases --- Biological Products --- Virus Diseases --- Viruses --- Health Care --- Vertebrate Viruses --- Complex Mixtures --- Organisms --- Chemicals and Drugs --- Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Viral vaccines. --- Virus vaccines --- Influenza virus vaccines --- Medicine. --- Immunology. --- Pharmacology. --- Virology. --- Public health. --- Biomedicine. --- Pharmacology/Toxicology. --- Public Health. --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Sanitary affairs --- Social hygiene --- Health --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation --- Microbiology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Physiological effect --- Viral vaccines --- Medical virology. --- Toxicology. --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Medical microbiology --- Virology --- Virus diseases --- Toxicology

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Immunology. Immunopathology --- Hygiene. Public health. Protection --- Pharmacology. Therapy --- Medical microbiology, virology, parasitology --- immunologie --- volksgezondheid --- farmacie --- farmacologie --- pandemie --- virologie --- toxicologie --- influenza --- vaccinatie

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This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals. .

Immunology. Immunopathology --- Hygiene. Public health. Protection --- Medical microbiology, virology, parasitology --- Infectious diseases. Communicable diseases --- immunologie --- vaccins --- preventieve gezondheidszorg --- gezondheidspromotie --- besmettelijke ziekten --- vaccinatie

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Double-stranded RNA --- RNA Viruses --- RNA, Double-Stranded --- RNA Viruses