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Effective new treatments of heart disease are based on a refined understanding of cellular function and the heart's response to environmental stresses. Not surprisingly, therefore, the field of experimental cardiology has experienced a phase of rapid exponential growth during the last decade. The acquisition of new knowledge has been so fast that textbooks of cardiology or textbooks of cardiovascular physiology are often hard-pressed to keep up with the most important conceptual advances. Witness the explosive increase in knowledge about signaling pathways of cardiac growth, transcriptional regulation of cardiac metabolism, hormonal signaling, and the complex responses of the heart to ischemia, reperfusion, or ischemic preconditioning. This book is meant to bridge the gap between original literature and textbook reviews. It brings together investigators of various backgrounds who share their expertise in the biology of myocardial ischemia. Each chapter is a self-contained mini-review, but it will soon become apparent to the reader that there is also a common thread: Molecular and cellular cardiology has never been more exciting than now, but ever more exciting times are yet to come. Dennis V. Cokkinos, MD, PhD, is a Professor of Cardiology at the University of Athens and Chairman of the Cardiology Department at Onassis Cardiac Surgery Center, Athens, Greece. Constantinos I. Pantos, MD, PhD, is an Assistant Professor of Pharmacology, Department of Pharmacology, Medical School, University of Athens, Athens, Greece. Gerd Heusch, MD, PhD, is a Professor of Medicine and Director of the Institute of Pathophysiology, Department of Internal Medicine, University of Essen, Essen, Germany. Heinrich Taegtmeyer, MD, DPhil, is a Professor of Medicine and Co-Director of the Division of Cardiology, The University of Texas, Houston Medical School, Houston, Texas, USA. .

Coronary heart disease --- Pathophysiology. --- Treatment. --- Medicine. --- Cardiology. --- Medicine & Public Health. --- Heart --- Internal medicine --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Diseases

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This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of cardiac cell death, cardiac remodelling and cardiac regeneration. Potential future research directions are also proposed, enabling the reader to gain a broad in-depth understanding of the topic. Myocardial Preservation: Translational Research and Clinical Application presents a thorough review of myocardial preservation. Its comprehensive approach provides a valuable reference for cardiology researchers and practising and trainee cardiologists seeking new insight to the topic.

Cardiology. --- Toxicology. --- Pharmacology/Toxicology. --- Myocardium --- Diseases --- Treatment. --- Prevention. --- Cardiac muscle --- Heart --- Heart muscle --- Muscles --- Muscle --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Internal medicine --- Toxicology --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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The term “Translational Research” reflects today’s integration of basic research (“bench”) findings with the clinical practice of medicine, and in a wider scope the application of results from the individual patient (“bedside”) to entire populations for the improvement of public health. This book offers future researchers a stimulus in many aspects of cardiovascular research, so as to promote their interest in future fields of cardiovascular disease, diagnosis and treatment. Introduction to Translational Cardiovascular Research discusses the fundamental and important aspects of the topic. It describes the renin-angiotensin-aldosterone system, the beta adrenergic receptors and the hypothalamic-pituitary-adrenal axis, while covering genetic polymorphisms both generally and specifically as regards the vascular endothelium, and the use of microRNAs. As such, this book will be relevant to young physicians, nurses, and other scientists engaged in the clinical cardiovascular field who want to added research-oriented dimension to their efforts towards better understanding and practicing of medicine. It also aims to attract young basic researchers who want to develop a better comprehension of the organism as a whole, man or animal, that they are investigating.

Pathology of the circulatory system --- cardiologie

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Pathology of the circulatory system --- cardiologie