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This volume covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses.* Covers viral assembly using heterologous expression systems and cell extracts* Discusses molecular mechanisms in bacteriophage T7 procapsid assembly, maturation and DNA containment* Includes informa

Viruses. --- Viral proteins. --- Microbial proteins --- Genetic vectors --- Microorganisms --- Mobile genetic elements --- Extrachromosomal DNA

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This edited book is written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM. This is a recently developed method to determine high-resolution structures of biological macromolecules. A major strength is the fact that cryo-EM does not require prior crystallization of protein complexes. It is especially well suited for larger complexes and molecular machines. This book provides a comprehensive, accessible and authoritative introduction to the field. It covers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data collection, data analysis, and the final validation of results.

Macromolecules --- Biomolecules --- High resolution imaging. --- Biophysics. --- SCIENCE / Life Sciences / Biophysics. --- Analysis. --- Analysis.