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Antibodies, Monoclonal --- Immunoglobulins --- Immunotherapy. --- Therapeutic use.

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In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.

Autoimmune diseases -- Gene therapy. --- Autoimmune diseases -- Therapy. --- Gene therapy -- Methods. --- Inflammation -- Gene therapy. --- Inflammation -- Therapy. --- Autoimmune diseases --- Inflammation --- Investigative Techniques --- Genetic Engineering --- Biological Therapy --- Immune System Diseases --- Pathologic Processes --- Diseases --- Genetic Techniques --- Pathological Conditions, Signs and Symptoms --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Gene Therapy --- Methods --- Autoimmune Diseases --- Medicine --- Health & Biological Sciences --- Clinical Immunology --- Pathology --- Gene therapy --- Inflammation. --- Gene therapy. --- Autoimmunologic diseases --- Therapy, Gene --- Inflammatory process --- Medicine. --- Immunology. --- Molecular biology. --- Pharmacology. --- Rheumatology. --- Biomedicine. --- Gene Therapy. --- Pharmacology/Toxicology. --- Molecular Medicine. --- Genetic engineering --- Autoimmunity --- Immunologic diseases --- Anti-inflammatory agents --- Toxicology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Internal medicine --- Connective tissues --- Joints --- Immunobiology --- Serology --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions and are becoming the molecules of choice for further combination therapies and cell engineering. Current developments and clinical successes are summarised by experts in the drug development field. A must read for immunologists, clinical scientists and novel drug developers.

Immunoglobulins --- Immunotherapy. --- Therapeutic use. --- Therapeutic immunology --- Clinical immunology --- Therapeutics --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Toxicology. --- Immunology. --- Human genetics. --- Oncology. --- Pharmacology/Toxicology. --- Human Genetics. --- Cancer Research. --- Tumors --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Immunobiology --- Life sciences --- Serology --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Pharmacology. --- Cancer research. --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.

Molecular biology --- History of human medicine --- Immunology. Immunopathology --- Pharmacology. Therapy --- Pathology of the organs of movement --- immunologie --- farmacologie --- toxicologie --- reumatologie --- gentherapie --- moleculaire biologie