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This book summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then it discusses the new formats and research technology of ADCs, including the application of miniaturized antibodies in ADC synthesis, novel carriers for ADC design, the technology and application of site-specific conjugation, and approaches for analyzing the drug: antibody ratio (DAR), the study of pharmacokinetics of ADCs. This book combines the basic theory with the research technology. It can be used as a reference book for students, teachers and researchers of biomedical field.

Biology—Technique. --- Experimental immunology. --- Pharmaceutical chemistry. --- Medicine—Research. --- Biology—Research. --- Cytology. --- Clinical biochemistry. --- Immunological Techniques. --- Pharmaceutics. --- Biomedical Research. --- Cell Biology. --- Medical Biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Cell biology --- Cellular biology --- Biology --- Cells --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Immunology, Experimental --- Biology, Experimental --- Immunology --- Immunoconjugates. --- Immunotherapy. --- Immunologic Techniques. --- Chemistry, Pharmaceutical. --- Chemistry, Pharmaceutic --- Pharmaceutic Chemistry --- Pharmaceutical Chemistry --- Medicinal Chemistry --- Chemistry, Medicinal --- Antibody Dissociation --- Immunologic Technic --- Immunologic Technics --- Immunologic Technique --- Immunological Technics --- Immunological Techniques --- Technic, Immunologic --- Technics, Immunologic --- Technique, Immunologic --- Techniques, Immunologic --- Antibody Dissociations --- Dissociation, Antibody --- Dissociations, Antibody --- Immunological Technic --- Immunological Technique --- Technic, Immunological --- Technics, Immunological --- Technique, Immunological --- Techniques, Immunological --- Allergy and Immunology --- Immunity --- Immunochemistry --- Immunotherapies --- Combined Antibody Therapeutics --- Immunity, Active --- Immunologic Techniques --- Antibody-Drug Conjugates --- Immunoconjugate --- Radioimmunoconjugate --- Antibody Drug Conjugate --- Antibody-Drug Conjugate --- Radioimmunoconjugates --- Antibody Drug Conjugates --- Conjugate, Antibody Drug --- Conjugate, Antibody-Drug --- Conjugates, Antibody-Drug --- Drug Conjugate, Antibody --- Molecular Targeted Therapy --- methods --- Antibody-drug conjugates. --- Antibody-toxin conjugates.

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Pharmaceutical Biotechnology in Drug Development summarizes key concepts and the latest developments of biotechnology applied to the development of biopharmaceuticals. Chapters present a comprehensive collection of introductory biotechnology technologies and their modern concepts and cover pharmacokinetic and pharmacodynamic behavior of biopharmaceuticals and modification techniques of amino acids and nucleic acid. Other sections focus on topics such as gene therapy, immunological preparations and nanoparticles which are the major contributions of pharmaceutical biotechnology. Final chapters discuss emerging techniques in the field of pharmaceutical biotechnology to meet current patient and health care demand. This book is an essential reference useful for pharmaceutical scientists, clinicians and academic researchers who want easy access to up-to-date practices of pharmaceutical biotechnology. Corporate researchers will also benefit from this book’s succinct and objective content structure.

Drug Development. --- Nanoparticle Drug Delivery System. --- NDDSs --- Nano Delivery System --- Nano Drug Delivery Systems --- Nano-Drug Delivery System --- Nanoparticle Based Drug Delivery System --- Delivery System, Nano --- Delivery System, Nano-Drug --- Delivery Systems, Nano --- Delivery Systems, Nano-Drug --- Nano Delivery Systems --- Nano Drug Delivery System --- System, Nano Delivery --- System, Nano-Drug Delivery --- Systems, Nano Delivery --- Systems, Nano-Drug Delivery --- Medication Development --- Pharmaceutical Development --- Computational Prediction of Drug-Target Interactions --- Drug Target Prediction --- Development, Drug --- Development, Medication --- Development, Pharmaceutical --- Drug Target Predictions --- Prediction, Drug Target --- Target Prediction, Drug --- Pharmaceutical biotechnology. --- Drug development. --- Biological Products --- Biotechnology --- methods