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This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Proteolytic enzymes. --- Diseases --- Molecular aspects. --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Medicine --- Epidemiology --- Health --- Pathology --- Sick --- Peptide hydrolases --- Proteases --- Hydrolases --- Human physiology. --- Medicine. --- Pharmaceutical technology. --- Oncology. --- Human Physiology. --- Molecular Medicine. --- Pharmaceutical Sciences/Technology. --- Cancer Research. --- Tumors --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Physiology --- Human body --- Health Workforce --- Molecular biology. --- Cancer research. --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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This first volume of the comprehensive, two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the progression of different lung diseases. The lungs of humans and animals are under constant threat from oxidants from either endogenous (e.g. in situ metabolic reactions) or exogenous sources (e.g. air pollutants). Further, oxidative stress causes the oxidation of proteins, DNA and lipids, which in turn generates secondary metabolic products. The book consists of sections, each focusing on different aspects of oxidant-mediated lung diseases. As such it is a unique reference resource for postgraduate students, biomedical researchers and also for the clinicians who are interested in studying and understanding oxidant-mediated lung diseases. The second volume will incorporate other aspects of oxidant-mediated lung diseases, including prevention and therapeutics. .

Cytology. --- Pneumology. --- Human physiology. --- Medicine. --- Biochemistry. --- Biomedical engineering. --- Oxidative Stress. --- Pneumology/Respiratory System. --- Human Physiology. --- Molecular Medicine. --- Medical Biochemistry. --- Biomedical Engineering/Biotechnology. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Health Workforce --- Human biology --- Medical sciences --- Physiology --- Human body --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Oxidative stress. --- Respiratory organs—Diseases. --- Molecular biology. --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Molecular biochemistry --- Molecular biophysics --- Biomolecules --- Systems biology --- Oxidation-reduction reaction --- Stress (Physiology)

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Human biochemistry --- Immunology. Immunopathology --- Pathological biochemistry --- Pathology of the respiratory system --- anti-oxidantia --- vrije radicalen --- medische biochemie --- biochemie --- pneumologie --- immunochemie --- enzymen

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