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Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay, by Christine E. Kaiser, Vijay Gokhale, Danzhou Yang and Laurence H. Hurley.- Higher-Order Quadruplex Structures, by Luigi Petraccone.- Investigation of Quadruplex Structure Under Physiological Conditions Using In-Cell NMR, by Robert Hänsel, Silvie Foldynová-Trantírková, Volker Dötsch and Lukás Trantírek.- Circular Dichroism of Quadruplex Structures, by Antonio Randazzo, Gian Piero Spada and Mateus Webba da Silva.- Molecular Crowding and Hydration Regulating of G-Quadruplex Formation, by Daisuke Miyoshi, Takeshi Fujimoto and Naoki Sugimoto.- Visualizing the Quadruplex: From Fluorescent Ligands to Light-Up Probes, by Eric Largy, Anton Granzhan, Florian Hamon, Daniela Verga and Marie-Paule Teulade-Fichou.- Calculation of Hydrodynamic Properties for G-Quadruplex Nucleic Acid Structures from in silico Bead Models, by Huy T. Le, Robert Buscaglia, William L. Dean, Jonathan B. Chaires and John O. Trent.- Energetics of Ligand Binding to G-Quadruplexes, Concetta Giancola and Bruno Pagano.- Tetramolecular Quadruplex Stability and Assembly, by Phong Lan Thao Tran, Anne De Cian, Julien Gros, Rui Moriyama and Jean-Louis Mergny.

Quadruplex nucleic acids --- Chemistry --- Physical Sciences & Mathematics --- Organic Chemistry --- G-quadruplexes --- G-tetrads --- Guanine quadruplexes --- Tetraplex nucleic acids --- Chemistry. --- Bioorganic chemistry. --- Medical biochemistry. --- Nucleic acids. --- Biophysics. --- Biological physics. --- Bioorganic Chemistry. --- Nucleic Acid Chemistry. --- Medical Biochemistry. --- Biophysics and Biological Physics. --- Quadruplex nucleic acids. --- Nucleic acids --- Biochemistry. --- Biological and Medical Physics, Biophysics. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Polynucleotides --- Biomolecules --- Bio-organic chemistry --- Biological organic chemistry --- Biochemistry --- Chemistry, Organic --- Composition --- Biological physics --- Physics --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Pathology

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This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.

Nucleic Acids. --- DNA-Binding Proteins. --- RNA-Binding Proteins. --- Molecular Biology --- Drug Interactions. --- Nucleic acids. --- Ligand binding (Biochemistry). --- DNA-ligand interactions. --- Molecular pharmacology. --- Acides nucléiques --- Ligands (Biochimie) --- Interactions ADN-ligand --- Pharmacologie moléculaire --- methods. --- Fixation --- Nucleic Acids --- Proteins --- Amino Acids, Peptides, and Proteins --- Nucleic Acids, Nucleotides, and Nucleosides --- Chemicals and Drugs --- DNA-Binding Proteins --- DNA --- Acides nucléiques --- Pharmacologie moléculaire --- ds-DNA --- DNA, Double-Stranded --- Deoxyribonucleic Acid --- DNA, Double Stranded --- Double-Stranded DNA --- ds DNA --- DNA Binding Protein --- DNA Single-Stranded Binding Protein --- SS DNA BP --- Single-Stranded DNA-Binding Protein --- DNA Helix Destabilizing Proteins --- Single-Stranded DNA Binding Proteins --- Binding Protein, DNA --- DNA Binding Proteins --- DNA Single Stranded Binding Protein --- DNA-Binding Protein, Single-Stranded --- Single Stranded DNA Binding Protein --- Single Stranded DNA Binding Proteins --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Acids, Nucleic --- Biopolymers --- Molecular Mechanisms of Pharmacological Action --- DNA-Binding Protein --- Protein, DNA-Binding --- Protein --- Nucleic Acid --- Acid, Nucleic

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Organic chemistry --- General biochemistry --- Clinical chemistry --- klinische chemie --- medische chemie --- organische chemie --- biochemie