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Rapid actions of sex steroids play a critical role in mediating the biological outcome of target tissues. This book reviews the importance of these non-genomic effects in initiation and progression of breast and prostate cancers. Particular emphasis is placed on discussing how rapid steroid actions not only impact disease development and response to conventional therapies for these two types of cancers, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. The book reviews the fundamental basis of target development and the current status of these studies, which are providing valuable insights in key areas of breast and prostate cancers. Particular emphasis is placed on discussing how rapid steroid actions not only impact disease development and response to conventional therapies for these two types of cancers, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. The book reviews the fundamental basis of target development and the current status of these studies, which are providing valuable insights in key areas of breast and prostate cancers.
Breast -- Cancer -- Chemotherapy. --- Hormones, Sex -- Carcinogenicity. --- Hormones, Sex -- Receptors. --- Prostate -- Cancer -- Chemotherapy. --- Steroid hormones -- Therapeutic use. --- Hormones, Sex --- Breast --- Prostate --- Prostatic Diseases --- Gonadal Hormones --- Breast Diseases --- Genital Neoplasms, Male --- Receptors, Cytoplasmic and Nuclear --- Neoplasms by Site --- Therapeutics --- Urogenital Neoplasms --- Hormones --- Proteins --- Neoplasms --- Transcription Factors --- DNA-Binding Proteins --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genital Diseases, Male --- Skin Diseases --- Diseases --- Male Urogenital Diseases --- Amino Acids, Peptides, and Proteins --- Skin and Connective Tissue Diseases --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Chemicals and Drugs --- Breast Neoplasms --- Prostatic Neoplasms --- Drug Therapy --- Gonadal Steroid Hormones --- Receptors, Steroid --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Oncology --- Physiological effect --- Cancer --- Endocrine aspects --- Hormones, Sex. --- Steroid hormones. --- Sex factors. --- Treatment. --- Hormonal steroids --- Female sex hormone --- Male sex hormone --- Sex hormones --- Sex differences --- Medicine. --- Cancer research. --- Endocrinology. --- Biomedicine. --- Cancer Research. --- Biomedicine general. --- Steroids --- Steroid hormones
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Steroid Receptors: Methods and Protocols presents a selection of techniques that have been recently applied to the analysis of steroid receptors, powerful tools for the advancement of our understanding of both the mechanisms regulating gene transcription and the rapid signaling responses of tissues to signals. Research in this area has generated a wealth of data allowing the elucidation of steroid receptor mechanisms and improving the treatment of many endocrine disorders, above all cancers. Chapters cover methods to analyze gene transcription, chromatin and proteomic modifications, extra-nuclear signaling regulation, development of cell and animal models, and preparation of new antibodies. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Steroid Receptors: Methods and Protocols offers an updated view on a variety of modern methods that will hopefully contribute to improving our knowledge on the integration of steroid receptors in single or different functionally connected cellular contexts under a variety of physiological and pathological conditions, above all tumors.
Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition
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Human biochemistry --- Oncology. Neoplasms --- Pathological endocrinology --- medische biochemie --- biochemie --- endocrinologie --- oncologie --- steroïden
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Rapid actions of sex steroids play a critical role in mediating the biological outcome of target tissues. This book reviews the importance of these non-genomic effects in initiation and progression of breast and prostate cancers. Particular emphasis is placed on discussing how rapid steroid actions not only impact disease development and response to conventional therapies for these two types of cancers, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. The book reviews the fundamental basis of target development and the current status of these studies, which are providing valuable insights in key areas of breast and prostate cancers. Particular emphasis is placed on discussing how rapid steroid actions not only impact disease development and response to conventional therapies for these two types of cancers, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. The book reviews the fundamental basis of target development and the current status of these studies, which are providing valuable insights in key areas of breast and prostate cancers.
Human biochemistry --- Oncology. Neoplasms --- Pathological endocrinology --- medische biochemie --- biochemie --- endocrinologie --- oncologie --- steroïden
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