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Analytical chemistry --- Organic chemistry --- General biochemistry --- Oncology. Neoplasms --- Clinical chemistry --- klinische chemie --- medische chemie --- organische chemie --- analytische chemie --- biochemie --- oncologie

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reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a comparison of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and functional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a “time-resolved” picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology.

Tubulins --- Stabilizing agents --- Microtubules --- Chemistry --- Tubulin --- Nerve Tissue Proteins --- Microtubule Proteins --- Natural Science Disciplines --- Cytoskeleton --- Proteins --- Cytoplasmic Structures --- Disciplines and Occupations --- Cytoskeletal Proteins --- Biopolymers --- Amino Acids, Peptides, and Proteins --- Cytoplasm --- Polymers --- Macromolecular Substances --- Chemicals and Drugs --- Intracellular Space --- Cellular Structures --- Cells --- Anatomy --- Animal Biochemistry --- Pharmacy, Therapeutics, & Pharmacology --- Chemical Engineering --- Chemical & Materials Engineering --- Health & Biological Sciences --- Human Anatomy & Physiology --- Engineering & Applied Sciences --- Microtubules. --- Stabilizing agents. --- Tubulins. --- Agents, Stabilizing --- Stabilizers (Chemistry) --- Cytotubules --- Microtubule proteins --- Chemistry. --- Cancer research. --- Analytical chemistry. --- Organic chemistry. --- Medicinal chemistry. --- Biochemistry. --- Medicinal Chemistry. --- Biochemistry, general. --- Cancer Research. --- Organic Chemistry. --- Analytical Chemistry. --- Chemicals --- Cell organelles --- Oncology. --- Chemistry, Organic. --- Analytical biochemistry. --- Analytic biochemistry --- Biochemistry --- Chemistry, Analytic --- Organic chemistry --- Tumors --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Composition --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytical chemistry --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis --- Cancer research --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry