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Just 45 years ago, the age of gene modification was born. But GM is rapidly being supplanted by a new system called CRISPR or 'gene editing'. Scientists can now manipulate the genes of almost any organism with a degree of precision, ease and speed unthinkable only ten years ago. We can edit wheat genes to exclude the proteins that cause gluten intolerance. We can breed mosquitoes with a 'suicide gene' that kills their offspring before they can pass on Zika or yellow fever. But is it ethical ? If a person is suffering from a lethal genetic disease, is it unethical to deny them this option ? And who controls the application of this technology, when it makes 'biohacking' - perhaps of one's own genome - a real possibility ?

GENE EDITING --- GENE EDITING--MORAL AND ETHICAL ASPECTS

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From the author of the acclaimed The Epigenetics Revolution ('A book that would have had Darwin swooning' - Guardian) comes another thrilling exploration of the cutting edge of human science. For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions - 98% of the human genome - were dismissed as 'junk'. But in recent years researchers have discovered that variations in this 'junk' DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. Nessa Carey explores, for the first time for a general audience, the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself - and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.

DNA --- Genome, Human --- genetics --- Genomes

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Épigénétique. --- Carey, Nessa