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Shmuel Cabilly presents in Combinatorial Peptide Library Protocols a collection of new and unique techniques for the construction and use of peptide libraries. These powerful methods-often detailed here by their pioneers-include protocols for the chemical synthesis of peptide libraries, for constructing peptide libraries that are displayed on the surface of filamentous phage or bacteria, and for the rapid screening of these libraries for molecules with biospecific properties. Additional methods permit identifying specific enzyme substrates, investigating the recognition spectra of various binding proteins, epitope mapping, and identifying mimotopes. Combinatorial Peptide Library Protocols offers novice and experienced investigators alike the ability to select molecules from a randomized pool having specific biological activities. Its state-of-the-art techniques, combined with clear step-by-step instructions, make this book an essential tool in the selection of peptides suitable for drug development.

Protein binding --- Combinatorial chemistry --- Peptides --- Synthesis --- Protein Binding --- Peptide Library --- Molecular Sequence Data --- Gene Library --- Amino Acids, Peptides, and Proteins --- Metabolism --- Amino Acid Sequence --- Biochemical Processes --- Documentation --- Genetic Structures --- Chemical Processes --- Chemicals and Drugs --- Information Services --- Metabolic Phenomena --- Molecular Structure --- Biochemical Phenomena --- Phenomena and Processes --- Information Science --- Genetic Phenomena --- Chemical Phenomena --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Combinatorial chemistry. --- Protein binding. --- Synthesis. --- Life sciences. --- Biochemistry. --- Life Sciences. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Biosciences --- Sciences, Life --- Science --- Composition --- Binding, Protein --- Biochemistry --- Allosteric proteins --- Radioligand assay --- Combinatorial organic synthesis --- Combinatorial synthesis (Organic chemistry) --- High-throughput organic synthesis --- High-throughput synthesis (Organic chemistry) --- Multiple parallel synthesis (Organic chemistry) --- Organic compounds --- Pharmaceutical chemistry --- Biochips --- Peptide synthesis --- Peptides - Synthesis