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Since the discovery of the circulating "fibrocyte" in 1994 as a collagen-producing cell of the peripheral blood, the physiologic and pathologic role of this unique cell populaton has grown steadily. This pioneering new book provides the first comprehensive review of the role of fibrocytes in wound repair, granuloma formation, antigen presentation, scar formation, and various fibrosing disorders such as interstitial lung disease and nephrogenic systemic fibrosis. It also includes discussions of the recent studies on the molecular signals that influence fibrocyte migration, proliferation, and fu

Fibroblasts. --- Desmocytes --- Fibrocytes --- Connective tissue cells --- Stem cells

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In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-

Macrophage migration inhibitory factor. --- Macrophages. --- Histiocytes --- Mononuclear phagocytes --- Antigen presenting cells --- Connective tissue cells --- Killer cells --- Phagocytes --- Reticulo-endothelial system --- Inhibition factor, Macrophage migration --- Inhibitory factor, Macrophage migration --- Macrophage migration inhibition factor --- MIF (Macrophage migration inhibitory factor) --- Migration inhibition factor, Macrophage --- Migration inhibitory factor, Macrophage --- Lymphokines

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The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.

Life sciences. --- Immunology. --- Infectious diseases. --- Cytokines. --- Growth factors. --- Cell biology. --- Life Sciences. --- Cytokines and Growth Factors. --- Infectious Diseases. --- Cell Biology. --- Cellular immunity --- Immune response --- Regulation --- Emerging infectious diseases. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Immunobiology --- Life sciences --- Serology --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides

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Malaria is one of the most important "emerging" or "resurgent" infectious diseases. According to the World Health Organization, this mosquito-borne infection is a leading cause of suffering, death, poverty, and underdevelopment in the world today. Every year 500 million people become severely ill from malaria and more than a million people die, the great majority of them women and children living in sub-Saharan Africa. In 2008, it was estimated, a child would die of the disease every thirty seconds, making malaria - together with HIV/AIDS and tuberculosis - a global public health emergency. Th

Malaria --- prevention & control. --- history. --- Ague --- Chills and fever --- Intermittent fever --- Malarial fever --- Fever --- Protozoan diseases --- Prevention and control. --- History.