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This book presents the state of the art in the use of neuroimaging technologies in the study of schizophrenia and other primary psychotic disorders. The contributions of neuroimaging in the characterization of these disorders are reviewed across diagnoses, by focusing on psychopathological domains and at-risk populations in order to understand the implications for treatment. The principal neuroimaging findings are described in detail, identifying those that are common to and specific for each disorder and highlighting important pitfalls. Attention is drawn to potential translational aspects of research in the field, with discussion of emerging innovative perspectives. Neuroimaging research has shown that abnormalities of brain structure and function associated with psychiatric disorders do not reflect the boundaries of current diagnostic categories. However, neuroimaging findings are being reconsidered in the light of recent research proposals aimed at re-conceptualizing classification systems in Psychiatry. Written by leading experts, this book will appeal to all with an interest in the field, including researchers, clinicians, and trainees.

Psychiatry. --- Neurosciences. --- Psychology, clinical. --- Radiology, Medical. --- Neuropsychology. --- Neuroradiology. --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Neuroradiography --- Neuroradiology --- Neurophysiology --- Psychophysiology --- Diseases --- Nervous system—Radiography. --- Neuroscience.

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Psychiatry --- hallucinogens --- entactogens --- LSD --- MDMA --- psilocybin --- ayahuasca --- DMT --- therapy

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Psychiatry --- hallucinogens --- entactogens --- LSD --- MDMA --- psilocybin --- ayahuasca --- DMT --- therapy --- hallucinogens --- entactogens --- LSD --- MDMA --- psilocybin --- ayahuasca --- DMT --- therapy

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Previous research over the past decades has identified diverse neurobiological underpinnings of psychosis. In particular, by combining a variety of different neuroimaging modalities, it has been shown that psychotic states and the actual transition phase from a clinical high-risk state to established psychosis is characterized by structural, functional and neurochemical changes across different brain regions.Further evidence revealed that maybe not only focal brain abnormalities are characteristic for psychosis but specifically also an abnormal functional integration among various brain areas. Some evidence also suggests that dysfunctional brain connectivity proceeds during the development of psychosis when subjects perform a cognitive task. Notably, altered brain connectivity during cognitive challenges was often found to be associated with psychopathological measures, suggesting a mechanistic relation between functional network integrity and the clinical expression of psychosis ... In this research topic, we like to cover the most recent neurobiological correlates for early stage psychosis and in particular for the prediction of psychosis by using different neurophysiological measures (e.g. structural and functional MRI, EEG, DTI or PET). Studies exploring effective connectivity or complex brain networks such as small-world properties with techniques like dynamic causal modelling, structural equation modelling, or graph theory analysis are highly appreciated. Very welcome are studies proving a link between clinical features such as psychopathology and cognition, brain signals, and chemistry (also in regard of antipsychotic treatments or substance-induced psychotic states). Moreover, environmental factors that may influence psychosis onset or its’ developmental processes will be brought together with a diversity of different research modalities. We also collect critical reviews, mini-reviews or theoretical reflections from leading international researcher and clinicians in this field. The purpose of our research topic is intended to provide a state-of-the-art cognitive perspective to consider developing psychosis, which might shed more lights into the pathophysiological and neurobiological mechanisms of psychosis.

Psychoses --- Neuropsychiatry --- Physiological aspects. --- Research. --- Neuroimaging --- psychopathophysiology --- Computational Psychiatry --- psychosis high-risk state --- early detection and intervention --- dysfunctional brain connectivity --- Cognition --- Pharmacology --- psychosis --- prevention

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

precision psychiatry --- precision medicine --- personalized medicine --- biomarker --- machine learning --- computational psychiatry --- mood disorders --- schizophrenia