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ISBN: 9812813683 9789812813688 9789810232177 9810232179 Year: 2000 Publisher: Singapore River Edge, NJ World Scientific
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This important book comprises a narrative account of research on the hepatitis B virus (and related subjects) and selected reprints from the laboratory of Nobel laureate Baruch S Blumberg and his colleagues. The hepatitis B virus (HBV) is one of the ten most common deadly infectious diseases and is responsible for 1.1 million deaths a year worldwide.Research in his laboratory resulted in the discovery of HBV and the invention of the vaccine which protects one against it. The research began as an apparently esoteric study of human biochemical and immunologic variation. This required field-work in Africa, the Arctic, the Pacific, the Americas, and in many other locations and populations. The overall goal was to identify inherited biological differences which were related to differing responses to disease-causing agents. The virus was discovered using the blood of an infected person who had developed the antibody, to detect the virus present in another infected person who had become a carrier of the virus. Screening of blood donors led to the near-elimination of post-transfusion hepatitis B.There are now national HBV vaccination programs in more than 70 countries. During the past decade these programs have strikingly reduced the prevalence of HBV in many countries and there has been a significant drop in the incidence of cancer of the liver in the vaccinated cohorts. The HBV vaccination program is now, after smoking cessation, the most widely used cancer prevention program in the world.
Hepatitis B. --- Liver --- Homologous serum hepatitis --- Serum hepatitis --- Hepatitis, Viral --- Cancer --- Prevention.
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Year: 1962 Publisher: New York: Grune & Stratton,
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ISBN: 069100692X Year: 2002 Publisher: Princeton Princeton university press
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Hepatitis B vaccine --- Hepatitis B virus --- Research --- History --- Research --- History
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ISBN: 0691187231 Year: 2018 Publisher: Princeton, NJ : Princeton University Press,
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About 375 million people are infected with the hepatitis B virus. It has killed more people than AIDS and also causes millions of cases of liver cancer. The discovery of this deadly virus and the vaccine against it--a vaccine that is sharply decreasing the infection rate worldwide and is probably the first effective cancer vaccine--was one of the great triumphs of twentieth-century medicine. And it almost didn't happen. With wit and insight, this scientific memoir and story of discovery describes how Baruch Blumberg and a team of researchers found a virus they were not looking for and created a vaccine for a disease they previously knew little about--work that took the author around the world and won him the Nobel Prize. Blumberg and his collaborators were investigating relationships between gene distribution and disease susceptibility, research that was yielding interesting data but no real breakthroughs. Many viewed their work as more field trip than science. But, through decades of hard work and investigative twists and turns, their pursuit led to the hepatitis B antigen, the elusive virus itself, and, ultimately, the vaccine. As he takes the reader through the detective work that culminated in his incredible discovery, the author recounts with immediacy exciting moments in the lab and in the field--from a hair-raising flight to Africa to an unpleasant encounter with Alaskan sled dogs. The hepatitis B story is more than a fascinating chronicle of a major discovery. What Blumberg followed to the virus was a trail of remarkable "accidents" that happen when scientists seek answers to interesting questions. Those events, combined with the investigator's determined persistence, resulted in studies that generated a pharmaceutical industry, have far-flung public-health applications, and saved millions of lives.
Hepatitis B vaccine --- Hepatitis B virus --- Research --- History.
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ISBN: 9780691187235 Year: 2018 Publisher: Princeton, NJ
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ISBN: 0408703733 Year: 1972 Publisher: London Butterworths
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ISBN: 0306417235 Year: 1984 Publisher: New York London Plenum Press
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Year: 1961 Publisher: New York : Grune & Stratton,
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ISBN: 9780812292633 Year: 2015 Publisher: Philadelphia
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