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71.03 --- 72.036 --- 711.4 --- DDR --- Duitse Democratische Republiek --- Deutsche Demokratische Republik --- Duitsland --- Stedenbouw (geschiedenis) --- Twintigste eeuw (architectuur) --- 20ste eeuw (architectuur) --- Stedenbouw --- Architecture --- City planning --- Socialist realism and architecture --- Architecture and socialist realism --- Cities and towns --- Civic planning --- Land use, Urban --- Model cities --- Redevelopment, Urban --- Slum clearance --- Town planning --- Urban design --- Urban development --- Urban planning --- Land use --- Planning --- Art, Municipal --- Civic improvement --- Regional planning --- Urban policy --- Urban renewal --- Architecture, Western (Western countries) --- Building design --- Buildings --- Construction --- Western architecture (Western countries) --- Art --- Building --- Government policy --- Management --- Design and construction --- Architecture, Primitive

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This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.

General microbiology --- Toxicology --- Pharmacology. Therapy --- Medical microbiology, virology, parasitology --- Infectious diseases. Communicable diseases --- medische microbiologie --- farmacologie --- microbiologie --- multimedia --- toxicologie --- besmettelijke ziekten --- moleculaire biologie --- enzymen

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Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action of bacterial toxins should prevent or cure the respective toxin-associated disease. Toxin inhibitors might be beneficial when the toxin acts in the absence of the producing bacteria (e.g., food poisoning), but also in combination with antibiotics in infectious diseases when the toxin-producing bacteria are present. The focus of this Special Issue of Toxins is on the development and characterization of novel inhibitors against bacterial toxins, e.g., toxin neutralizing antibodies, peptides or small compounds, as well as toxin pore blockers, which interfere with bacterial toxins and thereby protect cells from intoxication.

Bacterial proteins. --- Bacterial toxins.

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Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action of bacterial toxins should prevent or cure the respective toxin-associated disease. Toxin inhibitors might be beneficial when the toxin acts in the absence of the producing bacteria (e.g., food poisoning), but also in combination with antibiotics in infectious diseases when the toxin-producing bacteria are present. The focus of this Special Issue of Toxins is on the development and characterization of novel inhibitors against bacterial toxins, e.g., toxin neutralizing antibodies, peptides or small compounds, as well as toxin pore blockers, which interfere with bacterial toxins and thereby protect cells from intoxication.

Bacterial proteins. --- Bacterial toxins.

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72.036 --- 71.03 --- 711.4 --- Rindt, Otto --- Hopp, Hanns --- DDR --- Deutsche Demokratische Republik --- Duitse Democratische Republiek --- Duitsland --- Sachsen --- Sachsen-Anhalt --- Brandenburg --- Mecklenburg-Vorpommern --- Dresden --- Berlin --- Berlijn --- Magdeburg --- Chemnitz --- Karl-Marx-Stadt --- Stalinstadt --- Eisenhüttenstadt --- Schwerin --- Neubrandenburg --- Twintigste eeuw (architectuur) --- 20ste eeuw (architectuur) --- Stedenbouw (geschiedenis) --- Stedenbouw --- Architecture --- City planning --- History --- Cities and towns --- Civic planning --- Land use, Urban --- Model cities --- Redevelopment, Urban --- Slum clearance --- Town planning --- Urban design --- Urban development --- Urban planning --- Land use --- Planning --- Art, Municipal --- Civic improvement --- Regional planning --- Urban policy --- Urban renewal --- Architecture, Western (Western countries) --- Building design --- Buildings --- Construction --- Western architecture (Western countries) --- Art --- Building --- Government policy --- Management --- Design and construction --- Architecture, Primitive