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Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.

Hepacivirus. --- Hepatitis C virus. --- Hepatitis C virus --- Viral Vaccines --- Hepatitis, Viral, Human --- Flaviviridae --- Hepatitis Viruses --- Flaviviridae Infections --- Viruses --- Vaccines --- RNA Viruses --- Virus Diseases --- RNA Virus Infections --- Hepatitis --- Vertebrate Viruses --- Diseases --- Organisms --- Biological Products --- Liver Diseases --- Complex Mixtures --- Digestive System Diseases --- Chemicals and Drugs --- Viral Hepatitis Vaccines --- Hepacivirus --- Hepatitis C --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Immunology. --- Medical virology. --- Immunobiology --- HCV (Hepatitis C virus) --- Medicine. --- Drug resistance. --- Virology. --- Hepatology. --- Biomedicine. --- Drug Resistance. --- Life sciences --- Serology --- Gastroenterology --- Microbiology --- Resistance to drugs --- Pharmacology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Medical microbiology --- Virology --- Virus diseases --- Flaviviruses --- Hepatitis viruses --- Drug interactions. --- Clinical medicine. --- Interactions, Drug --- Drugs --- Medicine, Clinical --- Medicine --- Side effects

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A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.

Antiviral agents. --- Pharmacology. --- Virus diseases -- Chemotherapy. --- Virus Diseases -- drug therapy. --- Diseases --- Anti-Infective Agents --- Therapeutic Uses --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Antiviral Agents --- Virus Diseases --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Virus diseases --- Chemotherapy. --- Antiviral drugs --- Antivirals --- Medicine. --- Gene therapy. --- Drug resistance. --- Pharmaceutical technology. --- Virology. --- Biomedicine. --- Pharmacology/Toxicology. --- Pharmaceutical Sciences/Technology. --- Drug Resistance. --- Gene Therapy. --- Antiviral agents --- Anti-infective agents --- Virus inhibitors --- Chemotherapy --- Toxicology. --- Medical virology. --- Drug interactions. --- Therapy, Gene --- Genetic engineering --- Therapeutics --- Interactions, Drug --- Drugs --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Medical microbiology --- Virology --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Side effects --- Toxicology --- Resistance to drugs --- Microbiology --- Drug effects --- Medical pharmacology --- Medical sciences --- Pharmacy --- Physiological effect

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A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.