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The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorgenesis. This volume presents virtually all aspects of tumor biology because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Rho, Wnt, TGFbeta and p53. Hippo signaling is not solely involved in regulating “classic” tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.

Cancer -- Genetic aspects. --- Cancer -- Molecular aspects. --- Cellular signal transduction. --- Oncology. --- Cancer --- Neoplastic Processes --- Peptides --- Protein Kinases --- Neoplasms --- Phosphotransferases (Alcohol Group Acceptor) --- Amino Acids, Peptides, and Proteins --- Diseases --- Chemicals and Drugs --- Phosphotransferases --- Transferases --- Enzymes --- Enzymes and Coenzymes --- Intracellular Signaling Peptides and Proteins --- Protein-Serine-Threonine Kinases --- Cell Transformation, Neoplastic --- Medicine --- Health & Biological Sciences --- Oncology --- Genetic aspects --- Genetic aspects. --- Molecular aspects. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Cancer genetics --- Medicine. --- Cancer research. --- Medical microbiology. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Medical Microbiology. --- Biomedicine general. --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cancer genes --- Cytology. --- Microbiology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Microbial biology --- Biology --- Microorganisms --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Tumors --- Biomedicine, general. --- Health Workforce --- Cancer research