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This volume discusses the requirements, advantages, and limitations of studying cell culture. The chapters in this book cover topics such as in vitro blood-brain barrier functional assays in human iPSC-based models; neuron-glia interactions examines with in vitro co-culture; epigenetic changes in cultures neurons and astrocytes; rat brain slices; brain punching technique; and using microRNA for in vitro neurotoxicity testing and related disorders. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Authoritative and cutting-edge, Cell Culture Techniques, Second Edition is a valuable resource for students and experiences researchers who are interested in learning more and making risk decisions in this evolving field.

Neurosciences. --- Cell culture. --- Cell Culture. --- Cultures (Biology) --- Cytology --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Technique

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Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with

Brain -- Degeneration. --- Brain -- Growth. --- Developmental neurophysiology. --- Nervous systems -- Diseases. --- Environmental Pollution --- Neurodegenerative Diseases --- Neurobehavioral Manifestations --- Neurologic Manifestations --- Behavior and Behavior Mechanisms --- Nervous System Diseases --- Public Health --- Psychiatry and Psychology --- Signs and Symptoms --- Diseases --- Environment and Public Health --- Health Care --- Pathological Conditions, Signs and Symptoms --- Neurology --- Medicine --- Health & Biological Sciences --- Symptoms and General Pathology --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Symptoms and Signs --- Community Health --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Community --- Health, Public --- Preventive Medicine --- Education, Public Health Professional --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Focal Neurologic Deficits --- Manifestations, Neurologic --- Manifestations, Neurological --- Neurologic Dysfunction --- Neurologic Findings --- Neurologic Manifestation --- Neurologic Signs --- Neurologic Symptoms --- Neurological Manifestations --- Neurologic Deficits --- Neurologic Signs and Symptoms --- Deficit, Focal Neurologic --- Deficit, Neurologic --- Deficits, Focal Neurologic --- Deficits, Neurologic --- Dysfunction, Neurologic --- Dysfunctions, Neurologic --- Finding, Neurologic --- Findings, Neurologic --- Focal Neurologic Deficit --- Manifestation, Neurologic --- Manifestation, Neurological --- Neurologic Deficit --- Neurologic Deficit, Focal --- Neurologic Deficits, Focal --- Neurologic Dysfunctions --- Neurologic Finding --- Neurologic Sign --- Neurologic Symptom --- Neurological Manifestation --- Sign, Neurologic --- Signs, Neurologic --- Symptom, Neurologic --- Symptoms, Neurologic --- Nervous System --- Cognitive Manifestations --- Neurobehavioral Signs and Symptoms --- Cognitive Symptoms --- Signs and Symptoms, Neurobehavioral --- Cognitive Manifestation --- Cognitive Symptom --- Manifestation, Cognitive --- Manifestation, Neurobehavioral --- Manifestations, Cognitive --- Manifestations, Neurobehavioral --- Neurobehavioral Manifestation --- Symptom, Cognitive --- Symptoms, Cognitive --- Degenerative Diseases, Central Nervous System --- Degenerative Diseases, Neurologic --- Degenerative Diseases, Spinal Cord --- Degenerative Neurologic Diseases --- Degenerative Neurologic Disorders --- Nervous System Degenerative Diseases --- Neurodegenerative Disorders --- Neurologic Degenerative Conditions --- Neurologic Degenerative Diseases --- Neurologic Diseases, Degenerative --- Degenerative Diseases, Nervous System --- Degenerative Condition, Neurologic --- Degenerative Conditions, Neurologic --- Degenerative Neurologic Disease --- Degenerative Neurologic Disorder --- Neurodegenerative Disease --- Neurodegenerative Disorder --- Neurologic Degenerative Condition --- Neurologic Degenerative Disease --- Neurologic Disease, Degenerative --- Neurologic Disorder, Degenerative --- Neurologic Disorders, Degenerative --- Pollution, Environmental --- Soil Pollution --- Pollution, Soil --- Environmental Pollutants --- Behavior And Behavior Mechanism --- Developmental neurobiology. --- Nervous system --- Brain --- Degeneration. --- Growth. --- Degenerative brain diseases --- Degenerative brain disorders --- Degeneration (Pathology) --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Developmental neurology --- Neurogenesis --- Developmental biology --- Embryology --- Neurobiology --- Neuroplasticity --- Degeneration and regeneration --- Evolution

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In this book, international authorities address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.

General biochemistry --- Physiology of nerves and sense organs --- neurochemie

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Mercury (Hg) is a global pollutant that knows no environmental boundaries. Even the most stringent control of anthropogenic Hg sources will not eliminate exposure given its ubiquitous presence. Exposure to Hg occurs primarily via the food chain due to MeHg's accumulation in fish. Latest US statistics indicate that 46 States have fish consumption advisories. In addition, Hg is a common pollutant in hazardous waste sites, with an estimated 3-4 million children living within one mile of at least one of the 1,300+ active hazardous waste sites in the US. The effects on intellectual function in children prenatally exposed to MeHg via maternal fish consumption have been the subject of two on-going major, prospective, longitudinal studies in the Seychelles and the Faroe Islands. It is important to recognize that the risk for MeHg exposure is not limited only to islanders with high fish consumption. This book will provide state-of-the-art information to the graduate student training in toxicology, risk assessors, researchers and medical providers at large. It is aimed to bring the reader up to date on contemporary issues associated with exposure to methylmercury, from its effects on stem cells and neurons to population studies.

General biochemistry --- Physiology of nerves and sense organs --- Pharmacology. Therapy --- neurochemie --- farmacologie --- biochemie --- toxicologie

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Societal, ethical, and cost-related issues, not to mention the need for sound scientific methods, have led to new and refined methods for the evaluation of health risks associated with neurotoxic compounds, relevant and predictive of exposure, relatively inexpensive, and ideally amenable to high throughput analysis and a reduction in animal use.  Cell Culture Techniques presents thorough traditional chapters, such as those on various cell culture methods that have evolved over the years, as well as innovative approaches to neurotoxicologic testing.  Accordingly, this detailed volume describes how stem cells, computational biology, and other novel powerful methods can now be applied to address the challenges of neurotoxic testing.  As part of the Neuromethods series, this work provides the kind of intensive description and implementation advice that is crucial for getting optimal results in the laboratory.   Practical and authoritative, Cell Culture Techniques serves both the novice and the experienced neurotoxicologist by inspiring the further development of mechanistically-driven, cost-effective, high throughput series of tests needed to meet the many contemporary challenges.

Neurosciences. --- Neurochemistry. --- Biochemistry --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system