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Nervous system --- Neuropharmacology --- Clinical trials --- Diseases --- Controlled clinical trials --- Patient trials of new treatments --- Randomized clinical trials --- Trials, Clinical --- Clinical medicine --- Human experimentation in medicine --- Neurotropic drugs --- Neurosciences --- Pharmacology --- Research --- Drug effects --- Effect of drugs on

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During the 1990's, scientific advances in understanding the mechanisms and pathophysiology of acute central nervous system injury were offset by a history of disappointing results from Phase III clinical trials of novel neuroprotective drugs. Numerous novel compounds were "tested,? and seemingly fell by the wayside. This book is intended to focus on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. The authors explore the issues facing research in this area and the strategies that might lead to future success in this critical

Orthopaedics. Traumatology. Plastic surgery --- Nervous system --- Neuropharmacology --- Clinical trials --- Diseases --- Organophosphorus compounds --- Insecticides --- Cholinesterase inhibitors --- Carbamates --- toxicity --- poisoning