Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

Calcification. --- Biomineralization --- Bone --- Calcium in the body --- Cardiovascular medicine

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed. Cardiovascular Calcification and Bone Mineralization is an essential resource for clinicians, researchers, and other medical professionals in cardiology, pathology, and biomedical engineering.

Cardiology. --- Pathology. --- Biomedical engineering. --- Biomedical Engineering/Biotechnology. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Heart --- Internal medicine --- Biomedical Engineering. --- Calcification, Physiologic. --- Vascular Calcification. --- Cardiovascular Diseases. --- Cardiovascular Disease --- Disease, Cardiovascular --- Diseases, Cardiovascular --- Cardiology --- Vascular Calcinosis --- Calcification, Vascular --- Calcifications, Vascular --- Calcinoses, Vascular --- Calcinosis, Vascular --- Vascular Calcifications --- Vascular Calcinoses --- Vascular Stiffness --- Calcification, Physiological --- Physiologic Calcification --- Bone Mineralization --- Mineralization, Bone --- Physiological Calcification --- Bone and Bones --- Engineering, Biomedical --- Clinical Engineering --- Engineering, Clinical --- Biomedical Technology --- Minerals in the body. --- Body composition --- Mineral metabolism --- Calcificació --- Biomineralització --- Malalties del cor --- Malalties dels ossos --- Cardiologia --- Medicina interna --- Anestèsia en cardiologia --- Cardiologia geriàtrica --- Cardiologia pediàtrica --- Cardiologia veterinària --- Medicina intensiva en cardiologia --- Malalties cardiovasculars --- Malalties vasculars --- Malalties òssies --- Osteopaties --- Malalties de l'aparell locomotor --- Displàsia fibrosa òssia --- Osteïtis --- Osteodistròfia renal --- Osteoporosi --- Pseudoartrosi --- Raquitisme --- Ortopèdia --- Atac de cor --- Cardiopaties --- Malalties cardíaques --- Arrítmia --- Aturada cardíaca --- Dilatació del cor --- Endocarditis --- Insuficiència cardíaca --- Malalties del pericardi --- Malformacions del cor --- Malalts cardíacs --- Mineralització biològica --- Minerals en l'organisme --- Càlculs --- Trastorns del metabolisme --- Calci en l'organisme --- Teixit ossi

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.

Extracellular space. --- Cardiovascular system --- Diseases. --- Angiogenesis --- Atherosclerosis --- Extracellular vesicles --- Calcification --- Biomarkers --- Cardiovascular disease --- Inflammation --- Exosomes --- Platelets --- Heart valve

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- cardiovascular --- regenerative medicine --- heart valves --- arterial remodeling --- myocardium --- cardiac regeneration

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- cardiovascular --- regenerative medicine --- heart valves --- arterial remodeling --- myocardium --- cardiac regeneration --- cardiovascular --- regenerative medicine --- heart valves --- arterial remodeling --- myocardium --- cardiac regeneration