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Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

Chromatin. --- Semen -- chemistry. --- Spermatozoa -- chemistry. --- Sperm-Ovum Interactions. --- Spermatogenesis --- Infertility, Male --- Sex chromatin --- Germ Cells --- Chromosome Structures --- Infertility --- Medicine --- Genetic Processes --- DNA Packaging --- Biological Science Disciplines --- Gene Expression Regulation --- Nucleoproteins --- Genitalia --- Genetic Structures --- Cells --- Proteins --- Genetic Phenomena --- Health Occupations --- Natural Science Disciplines --- Cell Physiological Processes --- Genital Diseases, Male --- Chromosomes --- Anatomy --- Male Urogenital Diseases --- Amino Acids, Peptides, and Proteins --- Intranuclear Space --- Urogenital System --- Phenomena and Processes --- Cell Physiological Phenomena --- Disciplines and Occupations --- Diseases --- Cell Nucleus Structures --- Chemicals and Drugs --- Cell Nucleus --- Intracellular Space --- Cellular Structures --- Spermatozoa --- Physiology --- Chromatin --- Chromatin Assembly and Disassembly --- Pathology --- DNA Damage --- Zoology --- Health & Biological Sciences --- Gynecology & Obstetrics --- Animal Anatomy & Embryology --- Genetic aspects --- Infertility, Male. --- Human reproductive technology. --- Spermatozoa. --- Male gametes --- Sperm --- Assisted human reproduction --- Assisted conception --- Conception --- Human assisted reproduction --- Human reproduction --- Male infertility --- Male sterility --- Sterility, Male --- Technological innovations --- Medicine. --- Obstetrics. --- Endocrinology. --- Reproductive medicine. --- Urology. --- Cell biology. --- Developmental biology. --- Medicine & Public Health. --- Reproductive Medicine. --- Developmental Biology. --- Cell Biology. --- Obstetrics/Perinatology. --- Gametes --- Semen --- Medical technology --- Reproductive technology --- Generative organs, Male --- Cytology. --- Obstetrics/Perinatology/Midwifery. --- Genitourinary organs --- Maternal-fetal medicine --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Development (Biology) --- Growth --- Ontogeny --- Internal medicine --- Hormones --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Health aspects --- Endocrinology .

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This case-based guide is written from the clinician's perspective, dealing with a defined male infertility problem, tracing the actual clinical pathway arriving at the diagnosis, and discussing the treatment options and the likely outcome. Rather than focusing on excessive theoretical details, each chapter presents a unique clinical vignette or scenario, the relevant aspects of which are followed throughout the entire chapter, correlating specific fertility issues with clinical findings, describing treatment options, prognoses and procedures (when indicated), and concluding with practical clinical pearls. Opening with chapters describing current diagnoses of male infertility and semen analysis, the subsequent cases presented cover a variety of relevant topics in male infertility, including anabolic steroid use, ejaculatory and erectile dysfunction, azoospermia, Klinefelter Syndrome, varicocele, cystic fibrosis and spinal cord injury. Additional chapters discuss choosing the right assisted conception technique and developing and managing a sperm bank. Practical and illustrative of a wide array of male fertility issues, The Diagnosis and Treatment of Male Infertility is a go-to resource for clinical andrologists, reproductive endocrinologists, urologists, primary care physicians and any professional working to treat the infertile male.

Medicine. --- Primary care (Medicine). --- Reproductive medicine. --- Andrology. --- Medicine & Public Health. --- Reproductive Medicine. --- Primary Care Medicine. --- Infertility, Male. --- Infertility, Male --- Diagnosis. --- Treatment. --- Male infertility --- Male sterility --- Sterility, Male --- Generative organs, Male --- Infertility --- Diseases --- Emergency medicine. --- Medicine, Emergency --- Medicine --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Human reproduction --- Men --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Endocrine aspects --- Physiology --- Health aspects --- Primary medical care --- Medical care

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This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm. We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male .

DNA damage --- Research --- Methodology. --- Medicine. --- Endocrinology. --- Reproductive medicine. --- Andrology. --- Medicine & Public Health. --- Reproductive Medicine. --- Generative organs, Male --- Human reproduction --- Men --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Internal medicine --- Hormones --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Endocrine aspects --- Diseases --- Physiology --- Health aspects --- Damage, DNA --- Biochemical genetics --- Mutation (Biology) --- Endocrinology . --- Endocrinology and Metabolism Specialty --- Metabolism and Endocrinology Specialty --- Endocrine System Diseases --- Medicine, Reproductive --- Gynecology --- Reproductive Health --- Reproductive health.

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General embryology. Developmental biology --- Histology. Cytology --- Pathological endocrinology --- Urology. Andrology --- Gynaecology. Obstetrics --- endocrinologie --- obstetrie --- urologie --- perinatale sterfte --- cytologie --- embryologie (geneeskunde) --- vroedkunde --- histologie

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Bringing together the latest knowledge on the growth and development of children and the most important abnormalities of puberty, this comprehensive text presents the current views on the pathogenesis, diagnostic possibilities and therapeutic options of the main deviations from the normal course of puberty (e.g., precocious and delayed puberty). The chain of physical and hormonal changes in the transitional years is carefully followed, including the regulation of the hypothalamic pulse generator as well as the timing of puberty. Further topics include growth disturbances, adolescent varicocele, adolescent gynecomastia, polycystic ovary syndrome, pubertal acne, and the psychosocial development of adolescents with pubertal abnormalities. Written and edited by internationally noted experts, Puberty will be an excellent resource for pediatricians, endocrinologists, gynecologists, andrologists, urologists, family practitioners, child psychologists and public health specialists – all those who will be challenged in their everyday practice with the problems of puberty.

Paediatrics --- Pathological endocrinology --- Gynaecology. Obstetrics --- endocrinologie --- pediatrie --- puberteit --- vroedkunde