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Phytotherapy is probably the oldest form of medicine; however, it represents a new therapeutic tool for healthcare workers. Indeed plants are an infinite source of novel molecules, with countless possible combinations. This collection of articles (a Special Issue from Molecules) brings together the most up-to-date studies on the use of plant-derived compounds, ranging from their anti-inflammatory, antioxidant, and anticancer effects to the revision of the prominent literature.

natural products --- phenylpropanoids --- phenolic acids --- plants --- depression --- behavioral disorders --- forced swim test --- tail suspension test --- anti-cancer activities --- multifloroside --- 10-oxyderivatives of oleoside secoiridoids --- structure-activity relationship --- flow cytometry --- epigallocatechin-3-gallate --- EGCG --- catechin --- green tea --- cancer preventive --- pharmacological activities --- Amelanchier alnifolia Nutt. --- carriers --- powders --- bioactive compounds --- functional food --- Ageratina havanensis --- flavonoids --- UPLC-ESI-MS/MS --- P-glycoprotein --- antioxidant potential --- nootkatone --- anti-inflammatory --- acute inflammation --- granuloma --- Pharbitis nil --- colorectal cancer --- KRAS --- muscle function --- juglone --- NLRP3 inflammasome --- caspase-1 --- IL-1β --- IL-18 --- plant secondary metabolites --- natural compounds --- biological activity --- phytochemistry --- pharmacological activity --- plant side effects --- Talisia esculenta --- Brosimum gaudichaudii --- Genipa americana --- Bromelia antiacantha --- RA-3 --- nephrotoxicity --- triterpene --- antioxidant --- hyperuricemia --- Hibiscus acetosella --- phenolic compound --- antibacterial --- UPLC --- Tabebuia impetiginosa --- Taheebo --- traditional uses --- immunopharmacology --- immunological disorders --- hesperidin --- new-clean process extraction --- nanocrystals --- anti-ageing --- zingerone --- lipopolysaccharide --- inflammation --- anti-oxidant --- cytokine storm --- procalcitonin --- histopathology --- doxorubicin --- Mahonia aquifolium --- matrix metalloproteinases --- cytotoxicity --- human lung adenocarcinoma --- n/a

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Phytotherapy is probably the oldest form of medicine; however, it represents a new therapeutic tool for healthcare workers. Indeed plants are an infinite source of novel molecules, with countless possible combinations. This collection of articles (a Special Issue from Molecules) brings together the most up-to-date studies on the use of plant-derived compounds, ranging from their anti-inflammatory, antioxidant, and anticancer effects to the revision of the prominent literature.

Medicine --- natural products --- phenylpropanoids --- phenolic acids --- plants --- depression --- behavioral disorders --- forced swim test --- tail suspension test --- anti-cancer activities --- multifloroside --- 10-oxyderivatives of oleoside secoiridoids --- structure-activity relationship --- flow cytometry --- epigallocatechin-3-gallate --- EGCG --- catechin --- green tea --- cancer preventive --- pharmacological activities --- Amelanchier alnifolia Nutt. --- carriers --- powders --- bioactive compounds --- functional food --- Ageratina havanensis --- flavonoids --- UPLC-ESI-MS/MS --- P-glycoprotein --- antioxidant potential --- nootkatone --- anti-inflammatory --- acute inflammation --- granuloma --- Pharbitis nil --- colorectal cancer --- KRAS --- muscle function --- juglone --- NLRP3 inflammasome --- caspase-1 --- IL-1β --- IL-18 --- plant secondary metabolites --- natural compounds --- biological activity --- phytochemistry --- pharmacological activity --- plant side effects --- Talisia esculenta --- Brosimum gaudichaudii --- Genipa americana --- Bromelia antiacantha --- RA-3 --- nephrotoxicity --- triterpene --- antioxidant --- hyperuricemia --- Hibiscus acetosella --- phenolic compound --- antibacterial --- UPLC --- Tabebuia impetiginosa --- Taheebo --- traditional uses --- immunopharmacology --- immunological disorders --- hesperidin --- new-clean process extraction --- nanocrystals --- anti-ageing --- zingerone --- lipopolysaccharide --- inflammation --- anti-oxidant --- cytokine storm --- procalcitonin --- histopathology --- doxorubicin --- Mahonia aquifolium --- matrix metalloproteinases --- cytotoxicity --- human lung adenocarcinoma --- natural products --- phenylpropanoids --- phenolic acids --- plants --- depression --- behavioral disorders --- forced swim test --- tail suspension test --- anti-cancer activities --- multifloroside --- 10-oxyderivatives of oleoside secoiridoids --- structure-activity relationship --- flow cytometry --- epigallocatechin-3-gallate --- EGCG --- catechin --- green tea --- cancer preventive --- pharmacological activities --- Amelanchier alnifolia Nutt. --- carriers --- powders --- bioactive compounds --- functional food --- Ageratina havanensis --- flavonoids --- UPLC-ESI-MS/MS --- P-glycoprotein --- antioxidant potential --- nootkatone --- anti-inflammatory --- acute inflammation --- granuloma --- Pharbitis nil --- colorectal cancer --- KRAS --- muscle function --- juglone --- NLRP3 inflammasome --- caspase-1 --- IL-1β --- IL-18 --- plant secondary metabolites --- natural compounds --- biological activity --- phytochemistry --- pharmacological activity --- plant side effects --- Talisia esculenta --- Brosimum gaudichaudii --- Genipa americana --- Bromelia antiacantha --- RA-3 --- nephrotoxicity --- triterpene --- antioxidant --- hyperuricemia --- Hibiscus acetosella --- phenolic compound --- antibacterial --- UPLC --- Tabebuia impetiginosa --- Taheebo --- traditional uses --- immunopharmacology --- immunological disorders --- hesperidin --- new-clean process extraction --- nanocrystals --- anti-ageing --- zingerone --- lipopolysaccharide --- inflammation --- anti-oxidant --- cytokine storm --- procalcitonin --- histopathology --- doxorubicin --- Mahonia aquifolium --- matrix metalloproteinases --- cytotoxicity --- human lung adenocarcinoma

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It is our pleasure to present this Special Issue of Pharmaceuticals, entitled “Applications of Liquid Chromatography in Analysis of Pharmaceuticals and Natural Products”. Plants produce a wide range of phytochemicals, which are secondary metabolites that confirm their identity and are used for the production of natural pharmaceuticals, among other things. The use of modern chromatographic techniques allows accurate quantitative and qualitative identification of the above-mentioned phytochemicals and their natural products. Liquid chromatography is one of the most efficient and robust specific techniques, due to the merits of convenience and strong separation ability, as well as a wide range of material applications for identification. Liquid chromatography is widely used for the analysis of plants, nutraceuticals, pharmaceuticals, natural product quality control, or quantitative determination of bioactive compounds. The most commonly used for the identification of different plant material and pharmaceuticals are the ultra- and high-performance liquid chromatography with UV-VIS, fluorescence, diode array, and equipped with mass spectrometry or tandem mass spectrometry detection methods. Therefore, for this Special Issue, we published works concerning the latest scientific news, insights, and advances in the field of innovation and applications of liquid chromatography in the analysis of phytochemicals and natural products.

Research & information: general --- Biology, life sciences --- Food & society --- in vitro biological activity --- bioactive compounds --- morphological parts --- medical plant --- Fragaria viridis --- creamy strawberry --- ellagitannins --- HPLC --- mass spectrometry --- fruit ripening --- antioxidant potential --- bisphenol A --- high-performance liquid chromatography --- ionic liquid --- dispersive liquid–liquid microextraction --- extraction kinetic studies --- tenofovir --- creatinine --- HPLC-UV --- hepatitis B virus --- human immunodeficiency virus --- anatoxin-a(s) --- neurotoxins --- cyanobacteria poisoning --- bio-accessibility --- isothiazolinones --- parabens --- cosmetics --- SPE --- UHPLC/DAD --- Gardenia jasminoides Ellis --- anti-diabetic activity --- LC-MS/MS --- GC-MS --- anti-oxidant --- Ficus glumosa --- polyphenols --- HPLC-ESI-MS/MS --- antiproliferative --- antioxidant --- Ayurveda --- Divya-Swasari-Vati --- herbal medicine --- UPLC/QToF MS --- validation --- Allium cepa L. --- Box–Behnken --- flavonoids --- quercetin glycosides --- liquid chromatography --- multiresponse optimization --- onion --- phenolic compounds --- UHPLC --- HPLC-MS/MS --- steroidal hormones --- anti-doping --- bovine blood --- equine blood --- natural products --- plant materials --- dietary supplements --- terpenes --- capillary liquid chromatography --- steroids --- skin permeability --- thin layer chromatography --- calculated physicochemical descriptors --- topical formulation --- anti-cellulite --- cosmetic --- monoterpenoids --- accelerated stability --- F0 concept --- steam sterilization --- sterilization safety --- glucose degradation products --- α-dicarbonyl compounds --- derivatization --- tandem mass spectrometry --- Geobacillus stearothermophilus --- paracetamol --- accuracy profile --- 3D printed --- formulation --- biorelevant media --- in vitro biological activity --- bioactive compounds --- morphological parts --- medical plant --- Fragaria viridis --- creamy strawberry --- ellagitannins --- HPLC --- mass spectrometry --- fruit ripening --- antioxidant potential --- bisphenol A --- high-performance liquid chromatography --- ionic liquid --- dispersive liquid–liquid microextraction --- extraction kinetic studies --- tenofovir --- creatinine --- HPLC-UV --- hepatitis B virus --- human immunodeficiency virus --- anatoxin-a(s) --- neurotoxins --- cyanobacteria poisoning --- bio-accessibility --- isothiazolinones --- parabens --- cosmetics --- SPE --- UHPLC/DAD --- Gardenia jasminoides Ellis --- anti-diabetic activity --- LC-MS/MS --- GC-MS --- anti-oxidant --- Ficus glumosa --- polyphenols --- HPLC-ESI-MS/MS --- antiproliferative --- antioxidant --- Ayurveda --- Divya-Swasari-Vati --- herbal medicine --- UPLC/QToF MS --- validation --- Allium cepa L. --- Box–Behnken --- flavonoids --- quercetin glycosides --- liquid chromatography --- multiresponse optimization --- onion --- phenolic compounds --- UHPLC --- HPLC-MS/MS --- steroidal hormones --- anti-doping --- bovine blood --- equine blood --- natural products --- plant materials --- dietary supplements --- terpenes --- capillary liquid chromatography --- steroids --- skin permeability --- thin layer chromatography --- calculated physicochemical descriptors --- topical formulation --- anti-cellulite --- cosmetic --- monoterpenoids --- accelerated stability --- F0 concept --- steam sterilization --- sterilization safety --- glucose degradation products --- α-dicarbonyl compounds --- derivatization --- tandem mass spectrometry --- Geobacillus stearothermophilus --- paracetamol --- accuracy profile --- 3D printed --- formulation --- biorelevant media

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In the search for a healthier diet and facing the uncertainties about the consumption of artificial additives, the scientific community has explored in the last years the potential of natural compounds, such as polyphenols, carotenoids, chlorophylls, essential oils, tocopherols, vitamins, polysaccharides, among others, obtained from the most diverse sources, such as plants and fungi, for the replacement of the artificial additives in food, which has made these compounds recognized as “natural additives”. In addition to being considered less harmful to health, and giving a certain functional property to a foodstuff, natural additives can also provide a beneficial synergistic effect in the food matrix. For the consumers, diverse studies have been showed that regular ingestion of bioactive compounds, that can be applied as natural additives, can be helpful for the prevention/treatment of several chronic and aging illnesses, such as cardiovascular diseases and neurological disorders. However, there is much to be researched on the viable use of bioactive compounds and to overcome their chemical limitations so that it can actually be used as natural additives in foods. This book addresses, through 18 scientific articles, some natural compounds with potential for use as preservatives, nutritional additives, coloring agents, flavorings, and various agents.

Technology: general issues --- trisodium citrate --- microbial transglutaminase --- casein gels --- textural properties --- microstructures --- Urtica spp. --- bioactive compounds --- antioxidant activity --- antimicrobial activity --- traditional medicine --- food industry --- animal breeding --- beta cyclodextrin --- ewe’s milk --- cheese --- Manchego --- lipids --- cholesterol --- anthocyanin --- natural extract --- tetraethyl orthosilicate --- black carrot --- black rice flour --- anthocyanins --- low gluten muffins --- added value products --- soymilk --- enzyme modified soymilk --- skim milk --- rennet induced gelation --- rheological properties --- egg yolk --- cholesterol extraction --- granules extraction --- anionic chelating biopolymers --- ADME --- absorption --- chlorophylls --- chlorophyllin --- green colorant --- zinc-chlorophylls --- copper-chlorophyll --- coloring foodstuff --- natural colorants --- food colors --- pomelo peel --- essential oil --- anti-oxidant --- anti-melanogenic --- B16 melanoma cell --- oxygen-containing sulfur flavor molecules --- β-carotene --- bis(2-methyl-3-furyl) disulfide (BMFDS) --- oxidation products --- beetroot --- betalains --- semi-preparative RP-HPLC --- in vitro human gastrointestinal digestion --- ex vivo colon fermentation --- antioxidant ability --- malonildialdehyde --- extra virgin olive oil --- leaf addition --- Tunisian varieties --- phenolics --- tocopherols --- Prunus spinosa L. fruit epicarp --- wild fruit valorization --- cyanidin 3-rutinoside --- peonidin 3-rutinoside --- heat and ultrasound assisted extraction --- response surface methodology --- Ocimum basilicum var. purpurascens leaves --- red rubin basil --- Heat-Assisted Extraction --- extraction optimization --- polyphenols --- tiger nut --- by-products --- solvent extraction --- horchata de chufa --- triple TOF-LC-MS-MS --- Caenorhabditis elegans --- antioxidants --- bergenin --- stress resistance --- lifespan --- Huntington --- uxi --- Endopleura uchi --- Allium cepa red cv. --- Citrus limon --- pickling --- volatiles --- SPME --- chemometrics --- byproducts --- food additives --- antimicrobial --- antioxidant --- colorants --- texturizing agents --- foaming capacity and emulsifiers --- trisodium citrate --- microbial transglutaminase --- casein gels --- textural properties --- microstructures --- Urtica spp. --- bioactive compounds --- antioxidant activity --- antimicrobial activity --- traditional medicine --- food industry --- animal breeding --- beta cyclodextrin --- ewe’s milk --- cheese --- Manchego --- lipids --- cholesterol --- anthocyanin --- natural extract --- tetraethyl orthosilicate --- black carrot --- black rice flour --- anthocyanins --- low gluten muffins --- added value products --- soymilk --- enzyme modified soymilk --- skim milk --- rennet induced gelation --- rheological properties --- egg yolk --- cholesterol extraction --- granules extraction --- anionic chelating biopolymers --- ADME --- absorption --- chlorophylls --- chlorophyllin --- green colorant --- zinc-chlorophylls --- copper-chlorophyll --- coloring foodstuff --- natural colorants --- food colors --- pomelo peel --- essential oil --- anti-oxidant --- anti-melanogenic --- B16 melanoma cell --- oxygen-containing sulfur flavor molecules --- β-carotene --- bis(2-methyl-3-furyl) disulfide (BMFDS) --- oxidation products --- beetroot --- betalains --- semi-preparative RP-HPLC --- in vitro human gastrointestinal digestion --- ex vivo colon fermentation --- antioxidant ability --- malonildialdehyde --- extra virgin olive oil --- leaf addition --- Tunisian varieties --- phenolics --- tocopherols --- Prunus spinosa L. fruit epicarp --- wild fruit valorization --- cyanidin 3-rutinoside --- peonidin 3-rutinoside --- heat and ultrasound assisted extraction --- response surface methodology --- Ocimum basilicum var. purpurascens leaves --- red rubin basil --- Heat-Assisted Extraction --- extraction optimization --- polyphenols --- tiger nut --- by-products --- solvent extraction --- horchata de chufa --- triple TOF-LC-MS-MS --- Caenorhabditis elegans --- antioxidants --- bergenin --- stress resistance --- lifespan --- Huntington --- uxi --- Endopleura uchi --- Allium cepa red cv. --- Citrus limon --- pickling --- volatiles --- SPME --- chemometrics --- byproducts --- food additives --- antimicrobial --- antioxidant --- colorants --- texturizing agents --- foaming capacity and emulsifiers

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• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

It is our pleasure to present this Special Issue of Pharmaceuticals, entitled “Applications of Liquid Chromatography in Analysis of Pharmaceuticals and Natural Products”. Plants produce a wide range of phytochemicals, which are secondary metabolites that confirm their identity and are used for the production of natural pharmaceuticals, among other things. The use of modern chromatographic techniques allows accurate quantitative and qualitative identification of the above-mentioned phytochemicals and their natural products. Liquid chromatography is one of the most efficient and robust specific techniques, due to the merits of convenience and strong separation ability, as well as a wide range of material applications for identification. Liquid chromatography is widely used for the analysis of plants, nutraceuticals, pharmaceuticals, natural product quality control, or quantitative determination of bioactive compounds. The most commonly used for the identification of different plant material and pharmaceuticals are the ultra- and high-performance liquid chromatography with UV-VIS, fluorescence, diode array, and equipped with mass spectrometry or tandem mass spectrometry detection methods. Therefore, for this Special Issue, we published works concerning the latest scientific news, insights, and advances in the field of innovation and applications of liquid chromatography in the analysis of phytochemicals and natural products.

Research & information: general --- Biology, life sciences --- Food & society --- in vitro biological activity --- bioactive compounds --- morphological parts --- medical plant --- Fragaria viridis --- creamy strawberry --- ellagitannins --- HPLC --- mass spectrometry --- fruit ripening --- antioxidant potential --- bisphenol A --- high-performance liquid chromatography --- ionic liquid --- dispersive liquid–liquid microextraction --- extraction kinetic studies --- tenofovir --- creatinine --- HPLC-UV --- hepatitis B virus --- human immunodeficiency virus --- anatoxin-a(s) --- neurotoxins --- cyanobacteria poisoning --- bio-accessibility --- isothiazolinones --- parabens --- cosmetics --- SPE --- UHPLC/DAD --- Gardenia jasminoides Ellis --- anti-diabetic activity --- LC-MS/MS --- GC-MS --- anti-oxidant --- Ficus glumosa --- polyphenols --- HPLC-ESI-MS/MS --- antiproliferative --- antioxidant --- Ayurveda --- Divya-Swasari-Vati --- herbal medicine --- UPLC/QToF MS --- validation --- Allium cepa L. --- Box–Behnken --- flavonoids --- quercetin glycosides --- liquid chromatography --- multiresponse optimization --- onion --- phenolic compounds --- UHPLC --- HPLC-MS/MS --- steroidal hormones --- anti-doping --- bovine blood --- equine blood --- natural products --- plant materials --- dietary supplements --- terpenes --- capillary liquid chromatography --- steroids --- skin permeability --- thin layer chromatography --- calculated physicochemical descriptors --- topical formulation --- anti-cellulite --- cosmetic --- monoterpenoids --- accelerated stability --- F0 concept --- steam sterilization --- sterilization safety --- glucose degradation products --- α-dicarbonyl compounds --- derivatization --- tandem mass spectrometry --- Geobacillus stearothermophilus --- paracetamol --- accuracy profile --- 3D printed --- formulation --- biorelevant media