Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Neurokinin NK1 receptor antagonists may have therapeutic potential in the treatment of anxiety and depression. Species variants in the NK1 receptor result in reduced affinity of NK1 receptor antagonists at rat and mouse NK1 receptors, making it difficult to test NK1 antagonists in traditional preclinical models of anxiety and depression. Gerbil NK1 receptors are similar in homology to the human NK1 receptor. In a companion article, we described the anxiety-like behavioral profile of gerbils on an adapted elevated plus-maze, and the ability of anxiolytic drugs to produce anti-anxiety effects in the gerbil elevated plus-maze. The aim of the present study was to determine whether oral (p.o.) administration of the NK1 receptor antagonists MK-869, L-742,694, L-733,060, CP-99,994, and CP-122,721 produced anxiolytic-like effects in the gerbil elevated plus-maze. Upon testing, all five NK1 antagonists produced anxiolytic-like effects. MK-869 (0.01-3 mg/kg) was the most potent NK1 antagonist, producing anxiolytic-like effects on percentage of open arm time, percentage of open arm entries, stretch-attend postures, and head dips at 0.03-0.3 mg/kg doses. L-742,694 (1-30 mg/ kg) and L-733,060 (1-10 mg/kg) produced anxiolytic-like effects on percentage of open arm time and stretch-attend postures at 3-10 mg/kg doses. CP-99,994 (3-30 mg/kg) only produced an anxiolytic-like effect on stretch-attend postures. CP-122,721 (3-30 mg/kg) produced an anxiolytic-like effect on percentage of open arm time at 30 mg/kg. The order of potency of the NK1 antagonists to increase percentage of open arm time was very similar to their potency to block NK1 agonist-induced foot-tapping. These studies demonstrate that neurokinin NK1 receptor antagonists produce anxiolytic-like effects in a novel gerbil elevated plus-maze, and suggest that this is an appropriate model to test NK1 antagonists for preclinical anxiolytic activity. (C) 2002 American College of Neuropsychopharmacology. Published by Elsevi

Ability. --- Activity. --- Agonists. --- Anxiety. --- Anxiolytic activity. --- Anxiolytic drugs. --- Anxiolytic-like. --- Behavior. --- Depression. --- Drug. --- Drugs. --- Elevated plus maze. --- Elevated plus-maze. --- Gerbil. --- Gerbils. --- Human. --- Increase. --- Inhibition. --- Model. --- Models. --- Mouse. --- Neurokinin nk1 receptor antagonists. --- Neurokinin nk1 receptor. --- Nk1 receptor antagonists. --- Nkp608. --- Nonpeptide antagonist. --- Pharmacology. --- Posture. --- Potency. --- Rat. --- Rats. --- Receptor antagonist. --- Receptor. --- Receptors. --- Social-interaction test. --- Substance-p receptors. --- Tachykinin. --- Test. --- Time. --- Treatment.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book provides the English-speaking world with a comprehensive account of the still largely unknown work of Schelling's philosophy of mythology and revelation. Its achievement, however, is not archival but philosophical, elucidating the relation between Schelling and onto-theology. It explains how Schelling dealt with the problem of nihilism and onto-theology well before Nietzsche and Heidegger, arguing that Schelling surpasses onto-theology or the philosophy of presence a century prior to Heidegger. Overall, the author provocatively suggests that Heidegger is perhaps Schelling's genuine heir and by comprehensively interpreting Schelling's multifaceted late lectures he analyzes issues as diverse as the Ancient relation between thinking and Being, the Medieval debate between voluntarism and intellectualism, the overcoming of modern subjectivism and German Idealism as well as many themes in contemporary philosophy. The presentation is systematic rather than thematic, following Schelling's ages of the world through the Past, Present and Future. The results are daring, departing from the half-century long canonical reading of the late Schelling since Walter Schulz. This book is valuable for Schelling-scholars, historians of philosophy and theologians alike.

Metaphysics --- Schelling, von, Friedrich W.J. --- Schelling, Friedrich Wilhelm Joseph von. --- Shelling, Fridrikh Vilʹgelʹm, --- Schelling, F. W. J. --- Sheling, F., --- שלינג, י.פ.וו., --- שלינג, פ. --- 谢林, --- Philosophy & Religion --- Philosophy --- Schelling, Friedrich Wilhelm Joseph von, --- Schelling, Friedrich Wilhelm Joseph von --- Schelling, Friedrich Wilhelm Joseph --- Schelling, Federico Guillermo José --- von Schelling, Friedrich Wilhelm Joseph --- Freedom. --- God. --- Metaphysics. --- Nature. --- Potency. --- PHILOSOPHY / General. --- Schelling, Friedrich Wilhelm Joseph von, - 1775-1854

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Since the subject of high dilution effects is still a subject for debate, this volume provides evidence in support of effects from control clinical studies, clinical records from veteran physicians, controlled experiments on animals and plants, and in vitro tests without any organisms (Chapter II). An overview of the methods for preparing drugs at ultra high dilution is also provided as well as the basic principles of homeopathy, which has been alleviating human suffering through the use of these drugs for several hundred years (Chapter I). Chapter III provides physical basis of high dilutions as evidence from the NMR, IR, UV and fluorescence spectra of those drugs. Since water is used as the diluents media, the structure and dynamics of water polymers in relation to high dilution are discussed in order to facilitate easy comprehension of this physical aspect, the basic principles of spectroscopy are also described. Chapter IV focuses on the mechanism of action of potentized drugs in the living system, discussing the structure of the cell, the plasma membrane, the integral proteins on the membrane, the interaction between these proteins and high dilutions and the manifestations of the therapeutic effects of high dilutions. Some aspects, peculiar to homeopathy, such as the chief miasm psora, and the literalities and time modalities of symptoms and drug action are interpreted from a scientific perspective. Chapter IV ends with a brief discussion on water structures and the origin of life to show the natural evolution of high dilution effects. The book not only helps in understanding the physical basis of high dilutions and their mechanism of action in organisms but provides many new avenues of investigation into this interdisciplinary field of science.

Homeopathy --- Dilution. --- Drugs --- Attenuations, dilutions, and potencies. --- Dose-response relationship. --- High potency (Drugs) --- Dose-effect relationship --- Pharmacology --- Chemistry --- Dosage --- Toxicology. --- Biochemistry. --- Microbiology. --- Botany. --- Analytical biochemistry. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Medical Microbiology. --- Plant Sciences. --- Analytical Chemistry. --- Analytic biochemistry --- Biochemistry --- Chemistry, Analytic --- Botanical science --- Phytobiology --- Phytography --- Phytology --- Plant biology --- Plant science --- Biology --- Natural history --- Plants --- Microbial biology --- Microorganisms --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Chemicals --- Medicine --- Poisoning --- Poisons --- Composition --- Toxicology --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytical chemistry --- Pharmacology. --- Medical microbiology. --- Plant science. --- Analytical chemistry. --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Physiological effect --- Floristic botany

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Since first receiving approval in 1986, antibody-based therapeutics have been the most successful modality for the treatment of various diseases. This Special Issue of IJMS, “Recent Advances in Antibody Therapeutics”, presents leading-edge articles and reviews for discovery, development, and clinical applications of therapeutic antibodies, covering antibody drug conjugates (ADCs), GPCR-targeting antibodies, a functional antibody screening, bioassay of bispecific antibodies, antibody applications for cardiovascular diseases, antibody delivery to CNS, etc. The excellent studies in this Special Issue would valuable insight for scientists and clinicians in the field of therapeutic antibodies

interleukin 33 --- ST2 receptor --- scFv --- C2_2E12 --- bladder cancer --- antibodies --- immune checkpoint inhibitors --- antibody-drug conjugates --- sacituzumab govitecan --- enfortumab vedotin --- erdafitinib --- cost-effectiveness --- G protein-coupled receptor --- membrane protein --- antigen --- therapeutic antibody --- anti-angiogenesis --- delta-like ligand --- irinotecan --- paclitaxel --- VEGF --- SARS-CoV-2 --- spike protein --- receptor-binding domain --- phage display --- monoclonal antibody --- cytomegalovirus --- peptide/major histocompatibility complex class I complex --- T-cell-receptor-like antibody --- affinity maturation --- yeast surface display --- combinatorial antibody library --- agonist antibody --- cell fate --- bispecific antibodies --- bioassays --- mechanisms of action --- binding assays --- potency assays --- atherosclerosis --- inflammation --- antibody therapy --- blood–brain barrier --- antibody --- pharmacokinetics --- disposition --- biochemical and physicochemical properties --- Fc binding --- receptor-mediated transcytosis --- brain shuttle --- molecular Trojan horse --- transferrin --- anti-cancer antibody --- antibody engineering --- biophysical properties --- computational methods --- research cell bank --- antibody therapeutics --- recombinant antibodies --- intracellular antibodies --- single-chain antibody fragment --- nanobody --- Human papillomaviruses --- HPV oncoproteins --- HPV-associated cancer --- HPV cancer therapy --- asthma --- refractory asthma --- biomarker --- n/a --- blood-brain barrier

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

In 2002, after an altercation between Muslim vendors and Hindu travelers at a railway station in the Indian state of Gujarat, fifty-nine Hindu pilgrims were burned to death. The ruling nationalist Bharatiya Janata Party blamed Gujarat's entire Muslim minority for the tragedy and incited fellow Hindus to exact revenge. The resulting violence left more than one thousand people dead--most of them Muslims--and tens of thousands more displaced from their homes. Parvis Ghassem-Fachandi witnessed the bloodshed up close. In Pogrom in Gujarat, he provides a riveting ethnographic account of collective violence in which the doctrine of ahimsa--or nonviolence--and the closely associated practices of vegetarianism became implicated by legitimating what they formally disavow. Ghassem-Fachandi looks at how newspapers, movies, and other media helped to fuel the pogrom. He shows how the vegetarian sensibilities of Hindus and the language of sacrifice were manipulated to provoke disgust against Muslims and mobilize the aspiring middle classes across caste and class differences in the name of Hindu nationalism. Drawing on his intimate knowledge of Gujarat's culture and politics and the close ties he shared with some of the pogrom's sympathizers, Ghassem-Fachandi offers a strikingly original interpretation of the different ways in which Hindu proponents of ahimsa became complicit in the very violence they claimed to renounce.

Muslims --- Ethnic conflict --- Pogroms --- Gujarat Riots, India, 2002. --- Mohammedans --- Moors (People) --- Moslems --- Muhammadans --- Musalmans --- Mussalmans --- Mussulmans --- Mussulmen --- Religious adherents --- Islam --- Conflict, Ethnic --- Ethnic violence --- Inter-ethnic conflict --- Interethnic conflict --- Ethnic relations --- Social conflict --- Genocide --- Jews --- Massacres --- Riots --- Godhra Train Fire, Godhra, India, 2002 --- Violence against --- Persecutions --- 2002 pogrom. --- Ahmedabad. --- Ahmedabadis. --- Bharatiya Janata Party. --- Dalit. --- Gandhi. --- Godhra incident. --- Gujarat. --- Gulbarg Society. --- Hindu nationalism. --- Hindu pilgrim. --- HinduЍuslim divide. --- ISI. --- Indian national integration. --- Jain. --- Jainism. --- Muslim communities. --- Muslim. --- Muslims. --- Naroda Patiya. --- Pakistani intelligence services. --- Rajput. --- Sandesh. --- The Times of India. --- Vaishnava traditions. --- accumulated suggestion. --- ahimsa. --- anti-Gujarati plots. --- anti-Hindu. --- anti-Muslim pogrom. --- bandh. --- butcher. --- civic order. --- collective violence. --- communal aggregation. --- cosmopolitan freedom. --- cultural processes. --- cultural unity. --- dietary habits. --- economic discipline. --- ethnic cultivation. --- heterogeneity. --- identification. --- insinuation. --- krodh. --- low-intensity tension. --- meat eater. --- meat eating. --- middle class. --- modern decadence. --- news coverage. --- nonviolence. --- phantasmagoria. --- pogrom. --- political movement. --- potency. --- power. --- pratikriya. --- psychological processes. --- relief. --- sacrifice. --- separation. --- sexual fantasies. --- state police. --- stereotypes. --- terrorism. --- tofan. --- urban experience. --- urban spaces. --- vegetarianism. --- violence. --- wage earners. --- women. --- word imagery.