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The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. This book covers the topic of the hippocampus from various perspectives. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book collects evidence of various hippocampal functions in healthy and disordered brain.
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Hippocampus --- Hippocampus --- drug effects. --- physiology.
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Hippocampus --- Hippocampus --- Hippocampus --- growth & development --- anatomy & histology --- cytology
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Hippocampus (Brain) --- Hippocampus (Brain) --- Pathophysiology. --- Physiology.
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Hippocampus (Brain) --- Hippocampus (Brain) --- Differentiation --- Growth
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Hippocampus --- Metabolism -- Physiology --- Hippocampus --- Metabolism -- Physiology
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Cognition. --- Emotion. --- Hippocampus.
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Hippocampus (Brain) --- Neurobiology --- Hippocampus --- Hippocampus --- Memory --- anatomy & histology --- physiology --- physiology --- Mammals --- Hippocampus
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This dissertation by Sofie Sundberg investigates neural plasticity in hippocampal and cortical neuronal networks. The research primarily uses a transgenic mouse model, Ntsr1-Cre GN220, to study short-term synaptic plasticity and the role of Hedgehog signaling in hippocampal neuron plasticity. It explores the expression of certain enzymes and proteins in neurons, the effects of cholinergic modulation on CT neurons, and synaptic interactions influenced by historical signaling. The work aims to enhance understanding of neuronal communication and plasticity, contributing to knowledge about brain functions and potential therapeutic approaches for neurological disorders. This research is intended for the scientific community, particularly those in neuroscience and experimental medicine.