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Drug resistance in cancer cells. --- Drug resistance in microorganisms. --- Drug Resistance, Microbial. --- Drug resistance in cancer cells --- Drug resistance in microorganisms --- Antibiotic resistance in microorganisms --- Antibiotics resistance in microorganisms --- Bacterial resistance to antibiotics --- Drug resistance in micro-organisms --- Microbial drug resistance --- Resistance to drugs in microorganisms --- Microorganisms --- Antitumor drug resistance --- Cancer drug resistance --- Drug resistance in cancer --- Drug resistance in tumor cells --- Cancer cells --- Effect of drugs on

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Cancer chemotherapy can be traced back to the 1940’s and since then the world has witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can be treated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority of cytotoxic therapies. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. This book also introduces several of the current approaches that have been developed by established investigators in the field that are aimed at overcoming resistance. This book is the first that compiles studies on tumor cell sensitization and is useful for students, scientists, clinicians and pharmaceutical companies.

Radiation-sensitizing agents. --- Drug resistance in cancer cells. --- Antineoplastic agents --- Effectiveness. --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Drugs --- Cancer --- Antitumor drug resistance --- Cancer drug resistance --- Drug resistance in cancer --- Drug resistance in tumor cells --- Cancer cells --- Radiation --- Radiosensitizing agents --- Chemotherapy --- Sensitizing agents --- Oncology. --- Oncology  . --- Toxicology. --- Immunology. --- Cancer Research. --- Pharmacology/Toxicology. --- Immunobiology --- Life sciences --- Serology --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Cancer research. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Pharmacy --- Cancer research --- Physiological effect

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This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer. Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.

Medicine. --- Cancer research. --- Drug resistance. --- Cell biology. --- Bacteriology. --- Biomedicine. --- Drug Resistance. --- Cell Biology. --- Cancer Research. --- Drug resistance in microorganisms. --- Drug resistance in cancer cells. --- Antitumor drug resistance --- Cancer drug resistance --- Drug resistance in cancer --- Drug resistance in tumor cells --- Antibiotic resistance in microorganisms --- Antibiotics resistance in microorganisms --- Bacterial resistance to antibiotics --- Drug resistance in micro-organisms --- Microbial drug resistance --- Resistance to drugs in microorganisms --- Cancer cells --- Microorganisms --- Effect of drugs on --- Drug interactions. --- Cytology. --- Oncology. --- Microbiology --- Tumors --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Interactions, Drug --- Drugs --- Side effects --- Cancer research --- Resistance to drugs --- Pharmacology

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This comprehensive book on breast cancer brings together some of the leading experts in an attempt to better understand breast cancer disease, the factors that make it lethal and current research progress, integrating both basic research with clinical implications. This volume covers the following core issues: i) heterogeneity in breast cancer – statistics, epidemiology, breast cancer subtypes, racial disparity and the associated challenges, ii) available and upcoming model systems in breast cancer research, iii) breast cancer metastasis to bones and brain, iv) drug resistance mechanisms in breast cancer against targeted therapies and v) recent developments in breast cancer research – state of current research directions / technologies / approaches. With its comprehensive coverage of topics related to breast cancer, this volume is expected to have a very wide appeal. It serves as an excellent source of reference for students/beginning researchers just setting foot in the field and interested in getting to know all the aspects of this disease. The book should also appeal to advanced and senior researchers by bringing everyone up-to-date with the most current knowledge on various breast cancer topics of utmost relevance.

Cancer --Textbooks. --- Neoplasms. --- Breast --- Drug resistance in cancer cells --- Neoplasms by Site --- Breast Diseases --- Neoplastic Processes --- Drug Resistance --- Neoplasms --- Pathologic Processes --- Pharmacological Phenomena --- Skin Diseases --- Skin and Connective Tissue Diseases --- Pathological Conditions, Signs and Symptoms --- Diseases --- Physiological Phenomena --- Phenomena and Processes --- Neoplasm Metastasis --- Drug Resistance, Neoplasm --- Breast Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Metastasis. --- Cancer cells. --- Drug resistance in cancer cells. --- Cancer. --- Antitumor drug resistance --- Cancer drug resistance --- Drug resistance in cancer --- Drug resistance in tumor cells --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Dissemination --- Metastasis --- Medicine. --- Cancer research. --- Drug resistance. --- Biomedicine. --- Cancer Research. --- Drug Resistance. --- Resistance to drugs --- Pharmacology --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cancer cells --- Cells --- Pathology, Cellular --- Cancer invasiveness --- Cancer of unknown primary origin

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Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells’ energy centers. Besides the production of ATP through cellular respiration, mitochondria play a pivotal role in other aspects of the life and death of a cell: heat production, programmed cell death, the regulation of metabolic activity, immunity, and calcium homeostasis. A number of diseases are associated with mitochondrial dysfunction, including cardiovascular, neurological, inflammatory, and metabolic disorders as well as cancer. Mitochondria therefore represent an important therapy target, and it is not surprising that a number of different treatment strategies have emerged. Approaches targeting mitochondria can be split into two opposite categories: drugs that restore mitochondrial function and drugs that trigger mitochondria-mediated cell death. Targeted drug delivery to achieve the selective accumulation of drug molecules in mitochondria is complex and involves methods such as direct drug modification or encapsulation into nanocarriers.

Research & information: general --- Biology, life sciences --- retinal ischemia --- blood-brain barrier --- endothelial --- reactive oxygen species --- oxidative stress --- tunneling nanotubules --- neuron --- central nervous system --- inflammation --- hypoxia --- anticancer peptide (ACP) --- antimicrobial peptide (AMP) --- anticancer peptides --- antimicrobial peptides --- host defense peptides --- prediction --- random forest --- mitochondria --- mitochondrial DNA --- mitochondrial disorders --- pharmacological therapy --- gene therapy --- precision medicine --- cardiovascular disease --- drug delivery --- mitochondria dysfunctions --- nanocarriers --- oxoglutarate carrier --- malate-aspartate shuttle --- cancer metabolism --- ATP production --- diphenyleneiodonium --- NADPH-oxidase --- differentiation --- proliferation --- mitochondria-targeted antioxidants --- LPS --- mitochondrial ROS --- antitumor agents --- fluorescence lifetime imaging --- medicinal chemistry --- metabolic drug --- mitochondrial carrier --- melanoma --- plumbagin --- cytotoxic effect --- metabolism --- cholesterol --- lipid raft --- mitochondrial permeability transition pore --- alkylphospholipid analog --- edelfosine --- mitochondrial oncometabolites --- cancer drug resistance --- mitochondrial disease --- heteroplasmy --- mitochondrial gene delivery