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This book entitled Marine Algal Antioxidants, as a special issue of the Antioxidants journal, encloses eleven scientific articles with a preface written by the two editors, Christophe Brunet and Clementina Sansone. Marine Algal Antioxidants book reports advances of the research on marine photosynthetic organisms for the growth of biotechnological pipelines aimed to enhance antioxidant molecules production by algae. More than twenty scientists share the results of their research and highlight the relevance of algae for developing marine biotechnology products to flourish the requirements of nutraceuticals or cosmeceuticals in the defense of human health. Multidisciplinarity of the scientific approaches presented in this book – such as physiological, molecular, chemistry, technical or technological methodologies – lays the foundation for harmonizing the links between them towards the unique goal of the improvement of marine algal factory processes.

algae --- Chlorella --- Fucus --- detoxification --- environmental pollution --- antioxidants --- heavy metals --- selenium --- SOD-1 --- neurotoxicology --- aminoazuphrates --- clinical medicine --- nutrition --- neuropathology --- Dunaliella salina --- microalgae --- red LED --- blue LED --- growth --- carotenoids --- plastoquinol:oxygen oxidoreductase --- photosynthesis --- antioxidant activities --- Box–Behnken design --- microwave-assisted extraction --- polysaccharide --- Ulva pertusa --- seaweed --- 9-cis β-carotene --- all-trans β-carotene --- light intensity --- isomerisation --- light --- ascorbic acid --- phenolic compounds --- flavonoids --- photoprotection --- Phaeodactylum tricornutum --- fucoxanthin --- antioxidative --- antiproliferative --- antioxidant --- biodiversity --- genome–scale metabolic networks (GSMNs), data integration --- brown algae --- oxygenated carotenoid biosynthesis --- abscisic acid --- Saccharina japonica --- Cladosiphon okamuranus --- lipophilic antioxidant --- solvent blending --- macroalgae --- LC-ESI-MS/MS --- carotenoid pigment --- anthocyanin --- chlorophyll derivative --- phototrophic --- heterotrophic --- Scenedesmus --- chlorophylls --- hydroxy-chlorophyll --- oxidative metabolism --- ROS --- lactone-chlorophyll --- photoacclimation --- seaweeds --- green algae --- marine algae --- Ulva intestinalis --- Enteromorpha intestinalis --- quantification --- polyphenols --- apigenin --- accelerated solvent extraction --- ASE --- HPLC-LRMS --- HPLC-HRMS --- HPLC --- TPC --- Folin–Ciocalteu --- TFC --- qNMR --- n/a --- Box-Behnken design --- genome-scale metabolic networks (GSMNs), data integration --- Folin-Ciocalteu

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This book provides readers with a good overview of the status and exciting developments in the identification of health-promoting properties and potential applications of nutraceutical substances. It includes papers focused on modern analytical instrumentation and new methods and biological tests applied to the evaluation of plant foods, derived products, herbal products, and food supplements and the phytochemical characterization of innovative natural sources of bioactive compounds and relative health-promoting properties.

Research & information: general --- phenolic compounds --- bud derivatives --- Ribes nigrum glyceric macerate --- green chemistry --- pulsed ultrasound-assisted extraction --- untargeted spectroscopic fingerprint --- targeted chromatographic fingerprint --- common buckwheat sprout --- flavonoid isomer --- quercetin-3-O-robinobioside --- validation --- chromatographic separation --- anthocyanin --- chlorogenic acid --- flavonol --- polymeric color --- storage --- wild blueberry --- vinegar --- automatized method --- quantification --- Allium sativum L. --- agro-biodiversity --- local varieties --- bulb morphology --- phenols --- volatile compounds --- chestnut --- characterisation tool --- bioactive compounds --- sensory analysis --- multivariate approach --- fruit peels --- polyphenols --- phenolic acids --- flavonoids --- flavan-3-ols --- hydrolysable and condensed tannins --- antioxidant activities --- LC-MS and HPLC --- functional food --- fortified pasta --- β-glucans --- nutritional properties --- Corylus avellana L. --- nutrient composition --- hazelnut cultivars --- minerals --- tocopherols --- Solanum lycopersicum L. --- refrigerated storage --- fruit quality --- carotenoids --- total polyphenols content --- food analysis --- High Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) techniques --- Orbitrap --- High Resolution Mass Spectrometry (HRMS) --- natural substances --- antioxidant molecules --- phenolic compounds --- bud derivatives --- Ribes nigrum glyceric macerate --- green chemistry --- pulsed ultrasound-assisted extraction --- untargeted spectroscopic fingerprint --- targeted chromatographic fingerprint --- common buckwheat sprout --- flavonoid isomer --- quercetin-3-O-robinobioside --- validation --- chromatographic separation --- anthocyanin --- chlorogenic acid --- flavonol --- polymeric color --- storage --- wild blueberry --- vinegar --- automatized method --- quantification --- Allium sativum L. --- agro-biodiversity --- local varieties --- bulb morphology --- phenols --- volatile compounds --- chestnut --- characterisation tool --- bioactive compounds --- sensory analysis --- multivariate approach --- fruit peels --- polyphenols --- phenolic acids --- flavonoids --- flavan-3-ols --- hydrolysable and condensed tannins --- antioxidant activities --- LC-MS and HPLC --- functional food --- fortified pasta --- β-glucans --- nutritional properties --- Corylus avellana L. --- nutrient composition --- hazelnut cultivars --- minerals --- tocopherols --- Solanum lycopersicum L. --- refrigerated storage --- fruit quality --- carotenoids --- total polyphenols content --- food analysis --- High Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) techniques --- Orbitrap --- High Resolution Mass Spectrometry (HRMS) --- natural substances --- antioxidant molecules

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This book entitled Marine Algal Antioxidants, as a special issue of the Antioxidants journal, encloses eleven scientific articles with a preface written by the two editors, Christophe Brunet and Clementina Sansone. Marine Algal Antioxidants book reports advances of the research on marine photosynthetic organisms for the growth of biotechnological pipelines aimed to enhance antioxidant molecules production by algae. More than twenty scientists share the results of their research and highlight the relevance of algae for developing marine biotechnology products to flourish the requirements of nutraceuticals or cosmeceuticals in the defense of human health. Multidisciplinarity of the scientific approaches presented in this book – such as physiological, molecular, chemistry, technical or technological methodologies – lays the foundation for harmonizing the links between them towards the unique goal of the improvement of marine algal factory processes.

Technology: general issues --- algae --- Chlorella --- Fucus --- detoxification --- environmental pollution --- antioxidants --- heavy metals --- selenium --- SOD-1 --- neurotoxicology --- aminoazuphrates --- clinical medicine --- nutrition --- neuropathology --- Dunaliella salina --- microalgae --- red LED --- blue LED --- growth --- carotenoids --- plastoquinol:oxygen oxidoreductase --- photosynthesis --- antioxidant activities --- Box-Behnken design --- microwave-assisted extraction --- polysaccharide --- Ulva pertusa --- seaweed --- 9-cis β-carotene --- all-trans β-carotene --- light intensity --- isomerisation --- light --- ascorbic acid --- phenolic compounds --- flavonoids --- photoprotection --- Phaeodactylum tricornutum --- fucoxanthin --- antioxidative --- antiproliferative --- antioxidant --- biodiversity --- genome-scale metabolic networks (GSMNs), data integration --- brown algae --- oxygenated carotenoid biosynthesis --- abscisic acid --- Saccharina japonica --- Cladosiphon okamuranus --- lipophilic antioxidant --- solvent blending --- macroalgae --- LC-ESI-MS/MS --- carotenoid pigment --- anthocyanin --- chlorophyll derivative --- phototrophic --- heterotrophic --- Scenedesmus --- chlorophylls --- hydroxy-chlorophyll --- oxidative metabolism --- ROS --- lactone-chlorophyll --- photoacclimation --- seaweeds --- green algae --- marine algae --- Ulva intestinalis --- Enteromorpha intestinalis --- quantification --- polyphenols --- apigenin --- accelerated solvent extraction --- ASE --- HPLC-LRMS --- HPLC-HRMS --- HPLC --- TPC --- Folin-Ciocalteu --- TFC --- qNMR --- algae --- Chlorella --- Fucus --- detoxification --- environmental pollution --- antioxidants --- heavy metals --- selenium --- SOD-1 --- neurotoxicology --- aminoazuphrates --- clinical medicine --- nutrition --- neuropathology --- Dunaliella salina --- microalgae --- red LED --- blue LED --- growth --- carotenoids --- plastoquinol:oxygen oxidoreductase --- photosynthesis --- antioxidant activities --- Box-Behnken design --- microwave-assisted extraction --- polysaccharide --- Ulva pertusa --- seaweed --- 9-cis β-carotene --- all-trans β-carotene --- light intensity --- isomerisation --- light --- ascorbic acid --- phenolic compounds --- flavonoids --- photoprotection --- Phaeodactylum tricornutum --- fucoxanthin --- antioxidative --- antiproliferative --- antioxidant --- biodiversity --- genome-scale metabolic networks (GSMNs), data integration --- brown algae --- oxygenated carotenoid biosynthesis --- abscisic acid --- Saccharina japonica --- Cladosiphon okamuranus --- lipophilic antioxidant --- solvent blending --- macroalgae --- LC-ESI-MS/MS --- carotenoid pigment --- anthocyanin --- chlorophyll derivative --- phototrophic --- heterotrophic --- Scenedesmus --- chlorophylls --- hydroxy-chlorophyll --- oxidative metabolism --- ROS --- lactone-chlorophyll --- photoacclimation --- seaweeds --- green algae --- marine algae --- Ulva intestinalis --- Enteromorpha intestinalis --- quantification --- polyphenols --- apigenin --- accelerated solvent extraction --- ASE --- HPLC-LRMS --- HPLC-HRMS --- HPLC --- TPC --- Folin-Ciocalteu --- TFC --- qNMR

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Structural and Functional Analysis of Extracts in Plants collects 1 editorial, 3 reviews, and 26 research articles reporting recent research findings which cover several aspects of plant-derived bioactive compounds, to correlate extraction techniques with the chemical composition of extracts and their bioactivity for identifying molecules that might be used as active substances in a wide variety of areas.This book is a valuable resource for members of the scientific community wishing to further explore plants and the therapeutic applications of their bioactive compounds. It will appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.

Research & information: general --- Biology, life sciences --- hierarchical cluster analysis --- principal component analysis --- ultrasound-assisted extraction --- triterpenic acid --- Ziziphus jujuba --- water-pepper --- FRAP --- DPPH --- polarity-based solvent extraction --- α-amylase inhibition --- circular economy --- green biorefinery --- polyunsaturated fatty acids --- phytochemicals --- amino acids --- food and feed --- UHPLC-ESI-ORBITRAP-MS/MS --- Bergenia emeiensis --- polysaccharides --- optimization --- RSM --- acrylamide-induced damage --- Sorbus commixta fruit --- anti-melanoma activity --- caspase-3 --- polyphenolic compounds --- depression --- antioxidant --- cytokines --- anti-inflammatory --- cytotoxicity --- medicinal mushroom --- Psilocybe natalensis --- coak oak --- chlorophyll --- terpenes --- lupeol --- cuticular permeance --- Suaeda vermiculata --- halophyte --- aqueous-ethanolic extract --- liver toxicity --- hepatoprotective --- liver disorders --- mass spectrometry --- LC-MS --- HepG-2 --- HepG-2/ADR --- zebrafish --- toxicity --- embryotoxicity --- medicinal plant --- animal model --- Crocus sativus --- in vivo --- carrageenan --- analgesic --- antidepressant --- anticoagulant --- adipogenesis --- AMPK --- anti-obesity --- triglycerides --- UCP1 --- Anacardiaceae --- design of experiments (DOEs) --- flavonoids --- green extraction --- HPLC-DAD --- LC-MS/MS --- tannins --- ultrasound assisted-extraction (UAE) --- compact mass spectrometry --- cleansing properties --- detergent plants --- phytochemical --- tissue culture --- Arbutus pavarii --- antibacterial activity --- MRSA --- time-kill curves --- ultrahigh-performance liquid chromatography --- mass spectrometry (UHPLC- ESI-MS/MS) --- Trigonella stellata --- caffeic acid --- osteoporosis --- osteoblast --- osteoclast --- BMP --- Euphorbia cuneata --- Euphorbiaceae --- lipopolysaccharide --- oxidative stress --- NF-κB --- lung injury --- pachycereus weberi --- escontria chiotilla --- antioxidant activity --- phenolic compounds --- betalains --- food composition --- food analysis --- Scrophularia buergeriana --- S. koraiensis --- S. takesimensis --- harpagoside --- osteoclast differentiation --- RANKL --- Araucaria angustifolia --- bioactive compounds --- cysteine protease inhibitor --- functional food --- insecticide --- plant extracts --- termites --- tumor cells --- pine nuts --- urban pest --- polyphenols --- fruit development --- natural food colorant --- Sambucus canadensis --- Japanese knotweed --- Reynoutria --- Polygonum --- Polygonaceae --- anthraquinones --- emodin --- physcion --- HPTLC --- HPTLC-MS --- densitometry --- carrot juices --- carotenoids --- high-speed juicer --- low-speed juicer --- food processing --- extraction --- glucosinolates --- kale (Brassica oleracea var. acephala) --- phenolics --- candelilla plant --- antioxidant properties --- antimicrobial activity --- candelilla cultivation --- candelilla wax --- polysterols --- saponins --- therapeutic properties --- sage --- stirring and heating extraction --- mechanochemical extraction --- antiproliferative activity --- mutagenicity --- anticoagulant activity --- Rosmarinus officinalis --- hydroalcoholic extract --- Sam-Myo-Whan --- traditional medicine --- gouty arthritis --- inflammation --- monosodium urate --- Underutilized Mexican plants --- Cactus fruits --- Antioxidant activities --- Antiproliferative properties --- hierarchical cluster analysis --- principal component analysis --- ultrasound-assisted extraction --- triterpenic acid --- Ziziphus jujuba --- water-pepper --- FRAP --- DPPH --- polarity-based solvent extraction --- α-amylase inhibition --- circular economy --- green biorefinery --- polyunsaturated fatty acids --- phytochemicals --- amino acids --- food and feed --- UHPLC-ESI-ORBITRAP-MS/MS --- Bergenia emeiensis --- polysaccharides --- optimization --- RSM --- acrylamide-induced damage --- Sorbus commixta fruit --- anti-melanoma activity --- caspase-3 --- polyphenolic compounds --- depression --- antioxidant --- cytokines --- anti-inflammatory --- cytotoxicity --- medicinal mushroom --- Psilocybe natalensis --- coak oak --- chlorophyll --- terpenes --- lupeol --- cuticular permeance --- Suaeda vermiculata --- halophyte --- aqueous-ethanolic extract --- liver toxicity --- hepatoprotective --- liver disorders --- mass spectrometry --- LC-MS --- HepG-2 --- HepG-2/ADR --- zebrafish --- toxicity --- embryotoxicity --- medicinal plant --- animal model --- Crocus sativus --- in vivo --- carrageenan --- analgesic --- antidepressant --- anticoagulant --- adipogenesis --- AMPK --- anti-obesity --- triglycerides --- UCP1 --- Anacardiaceae --- design of experiments (DOEs) --- flavonoids --- green extraction --- HPLC-DAD --- LC-MS/MS --- tannins --- ultrasound assisted-extraction (UAE) --- compact mass spectrometry --- cleansing properties --- detergent plants --- phytochemical --- tissue culture --- Arbutus pavarii --- antibacterial activity --- MRSA --- time-kill curves --- ultrahigh-performance liquid chromatography --- mass spectrometry (UHPLC- ESI-MS/MS) --- Trigonella stellata --- caffeic acid --- osteoporosis --- osteoblast --- osteoclast --- BMP --- Euphorbia cuneata --- Euphorbiaceae --- lipopolysaccharide --- oxidative stress --- NF-κB --- lung injury --- pachycereus weberi --- escontria chiotilla --- antioxidant activity --- phenolic compounds --- betalains --- food composition --- food analysis --- Scrophularia buergeriana --- S. koraiensis --- S. takesimensis --- harpagoside --- osteoclast differentiation --- RANKL --- Araucaria angustifolia --- bioactive compounds --- cysteine protease inhibitor --- functional food --- insecticide --- plant extracts --- termites --- tumor cells --- pine nuts --- urban pest --- polyphenols --- fruit development --- natural food colorant --- Sambucus canadensis --- Japanese knotweed --- Reynoutria --- Polygonum --- Polygonaceae --- anthraquinones --- emodin --- physcion --- HPTLC --- HPTLC-MS --- densitometry --- carrot juices --- carotenoids --- high-speed juicer --- low-speed juicer --- food processing --- extraction --- glucosinolates --- kale (Brassica oleracea var. acephala) --- phenolics --- candelilla plant --- antioxidant properties --- antimicrobial activity --- candelilla cultivation --- candelilla wax --- polysterols --- saponins --- therapeutic properties --- sage --- stirring and heating extraction --- mechanochemical extraction --- antiproliferative activity --- mutagenicity --- anticoagulant activity --- Rosmarinus officinalis --- hydroalcoholic extract --- Sam-Myo-Whan --- traditional medicine --- gouty arthritis --- inflammation --- monosodium urate --- Underutilized Mexican plants --- Cactus fruits --- Antioxidant activities --- Antiproliferative properties

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Cancer is one of the major causes of death worldwide. It is a multifactorial heterogeneous disease characterized by the transformation of normal cells into malignant cells, which acquire an uncontrolled growth, immortality, invasiveness, and ability to form distant metastasis. Natural bioactive molecules may interfere with these processes and inhibit the carcinogenesis process. In this book, new molecules and extracts, mainly derived from plants, have been described as being able to alter tumor cell behavior and target several abnormal molecular pathways in cancer cells. Among different cancer cells, the more studied include those derived from glioblastoma, osteosarcoma, lung, breast and gastric cancer. These natural products could be an attractive source for the development of new preventative and therapeutic agents against cancer. They may be more selective and have weaker adverse effects compared to conventional chemotherapy drugs that are actually used for cancer treatment. Clinical trials are necessary to demonstrate whether the in vitro and in vivo animal data are reproduced in humans before the application of natural products in cancer prevention and treatment.

cytotoxic activity --- NCI-60 cancer cell line --- pristimerin --- Salacia crassifolia --- Celastraceae --- Brazilian Cerrado biome --- Salacia elliptica --- Cheiloclinium cognatum --- Plenckia populnea --- Aspergillus fumigatus --- Cordyceps sinensis --- isochromanes --- chiral resolution --- ECD calculation --- cytotoxicity --- coronarin D --- JNK --- osteosarcoma --- Zeylenone --- gastric cancer --- invasion --- migration --- apoptosis --- anti-cancer agents --- anthraquinones --- glycosyltransferase --- Dendrobium officinale --- structure elucidation --- anti-tumor activity --- plantation mode --- AR --- Ganoderma tsugae --- lipogenesis --- prostate cancer --- SREBP-1 --- ursolic acid --- betulinic acid --- triterpenoids --- necrotic --- quercetin --- quercetagetin --- patuletin --- lichen --- secondary metabolites --- tumidulin --- stemness potential --- colorectal cancer cells --- oncogene --- transcriptional regulation --- neferine --- FAK/S6K1 --- autophagy --- human neuroblastoma cells --- natural yellow Monascus pigments --- water-soluble --- antioxidation --- MCF-7 cells --- phloretin --- cell proliferation --- inflammation --- glucose uptake --- Catalpa speciosa --- Taxus cuspidata --- Magnolia acuminata --- phenols --- antioxidants --- anticancer --- Colocasia esculenta --- food bioactive --- tarin --- stable nanocapsules --- entrapment efficiency --- no-toxicity --- preclinical tests --- antitumoral activity --- chemotherapeutic adjuvant --- grape leaves --- ASE --- TP --- Antioxidant activities --- Antiproliferative --- pro-apoptotic effects --- Gene expression --- Nutraceuticals --- Cucurbitacin B --- gefitinib-resistant NSCLC --- EGFR --- lysosomal degradation --- CIP2A --- zerumbone --- cancer --- NF-κB --- IL-6/JAK2/STAT3 --- Akt --- FOXO1 --- multiple myeloma --- quality control --- naringenin --- flavonoids --- traditional preparation --- cancer stem cells --- phytochemicals --- plant-derived foods --- fruit --- vegetable --- cell signaling --- Artemisia absinthium --- endoplasmic reticulum stress --- mitochondrial-dependent pathway --- melanoma --- bee venom --- melittin --- temozolomide --- AKT --- MAPK --- antrodin C --- mTOR --- metabolic stability --- capsazepine --- inflammatory diseases --- ROS --- TRPV1 --- PI3K/AKT/mTOR --- CLE-10 --- LC3 --- MDA-MB-231 --- lactoferrin hydrolysate --- copper --- manganese --- gastric cancer cells --- anti-cancer activity --- molecular mechanism --- natural product alkaloids --- cephalotaxine --- protein synthesis inhibition --- antiproliferation agents --- folk medicine --- DLD-1 cells --- doxorubicin --- chemotherapy --- drug resistance --- CrataBL --- glioblastoma --- mesenchymal stem cells --- microenvironment --- plant lectin --- protease inhibitor --- cryptolepine --- neocryptolepine --- isocryptolepine --- antiproliferative activity --- structure activity relationships --- Licochalcone A --- ATM-Chk2 --- 13-ethylberberine --- mitochondrial ROS --- RT-R breast cancer cells --- diallyl disulfide --- PI3K/Akt/mTOR pathway --- Pulsatilla saponin D --- SB365 --- glioblastoma multiforme --- autophagic flux inhibition --- lysosomal membrane permeabilization --- mitochondrial membrane potential --- CLEFMA --- p38 --- proanthocyanins --- TNF-α --- lung adenocarcinoma --- natural compounds --- cervical cancer --- cell cycle arrest --- dicentrine --- metastasis --- glioma --- semi-synthetic derivative --- ingenol --- Euphorbia tirucalli --- protein kinase C --- seaweed --- porphyran --- carrageenan --- anti-cancer --- natural products --- n/a