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This work covers all aspects related to the obtainment, production, design, and processing of biopolymers obtained from natural resources. Moreover, it studies characteristics related to the improvement of their performance to increase their potential application at an industrial level, in line with the concept of a global circular economy. Thus, this work firstly classifies biopolymers obtained from natural resources (e.g., biobased building blocks and biopolymers extracted directly from plants and biomass), and then summarizes several cutting-edge research works focused on enhancing the performance of biopolymers from natural resources to extend their application in the industrial sector, and contribute to the transition to more sustainable plastics.

Technology: general issues --- History of engineering & technology --- PHBH --- almond shell flour --- mechanical properties --- thermal characterization --- WPCs --- bacterial polyesters --- poly(3-hydroxybutyrate-co-3hydroxyhexanoate)—PHBH --- poly(ε-caprolactone)—PCL --- binary blends --- improved toughness --- mechanical and thermal characterization --- Cucumis metuliferus --- extraction --- antioxidant activity --- coating --- cellulose acetate --- LDPE --- bilayer packaging --- active packaging --- poly(lactic acid) --- mechanical recycling --- yerba mate --- bionanocomposites --- polysulfide-derived polymers --- cottonseed oil --- fatty acid of cottonseed oil --- sodium soap of cottonseed oil --- PLA --- nanocomposites --- functional properties --- thymol --- migration --- films --- cutin --- cuticles --- bioplastics --- biopolymers --- solanum: CPMAS 13C NMR --- softgels --- mucilage --- in vitro digestion --- bioaccessibility --- bran content --- plasticized wheat flour --- citric acid --- biobased blends --- biopolymer --- carboxymethyl cellulose --- solid polymer electrolyte --- ionic transport --- chitosan --- potato starch --- microwave --- foam --- orthogonal experiments --- empty fruit bunch --- regenerated cellulose --- ionic liquid --- methyl methacrylate --- 3D printing --- syringe extrusion 3D printing --- hydroxypropyl methylcellulose --- orodispersible film --- phenytoin --- PA610 --- halloysite nanotubes (HNTs) --- flame retardant --- cone calorimeter --- agricultural waste --- asparagus --- CMC --- degree of substitution --- DS --- cellulose extraction --- thermoplastic starch --- dolomite --- biocomposite --- sonication --- bacterial cellulose --- nata de coco --- sodium hydroxide --- lignin --- nanoparticles --- biorefinery --- organosolv pretreatment --- polyelectrolyte multi-layers --- sodium alginate --- k-carrageenan --- cellulosic nonwoven textile --- surface functionalization --- characterization --- bio-sorption --- isotherms --- natural fibers --- soy protein --- chitin --- coir --- comfort --- functional textiles --- Circular Bioeconomy --- carbonation reaction --- selectivity optimization --- carbonated epoxidized linseed oil --- non-isocyanate polyurethane --- argan shell particles --- wood plastic composite --- polyethylene --- compatibilization --- air permeability --- fungal fibers --- hemp fibers --- microstructure --- mycocel --- softwood fibers --- virus membrane filtration --- allotropic transition --- choline chloride --- plasticizer --- starch dissolution --- n/a --- poly(3-hydroxybutyrate-co-3hydroxyhexanoate)-PHBH --- poly(ε-caprolactone)-PCL

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• Reference Manager
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This work covers all aspects related to the obtainment, production, design, and processing of biopolymers obtained from natural resources. Moreover, it studies characteristics related to the improvement of their performance to increase their potential application at an industrial level, in line with the concept of a global circular economy. Thus, this work firstly classifies biopolymers obtained from natural resources (e.g., biobased building blocks and biopolymers extracted directly from plants and biomass), and then summarizes several cutting-edge research works focused on enhancing the performance of biopolymers from natural resources to extend their application in the industrial sector, and contribute to the transition to more sustainable plastics.

PHBH --- almond shell flour --- mechanical properties --- thermal characterization --- WPCs --- bacterial polyesters --- poly(3-hydroxybutyrate-co-3hydroxyhexanoate)—PHBH --- poly(ε-caprolactone)—PCL --- binary blends --- improved toughness --- mechanical and thermal characterization --- Cucumis metuliferus --- extraction --- antioxidant activity --- coating --- cellulose acetate --- LDPE --- bilayer packaging --- active packaging --- poly(lactic acid) --- mechanical recycling --- yerba mate --- bionanocomposites --- polysulfide-derived polymers --- cottonseed oil --- fatty acid of cottonseed oil --- sodium soap of cottonseed oil --- PLA --- nanocomposites --- functional properties --- thymol --- migration --- films --- cutin --- cuticles --- bioplastics --- biopolymers --- solanum: CPMAS 13C NMR --- softgels --- mucilage --- in vitro digestion --- bioaccessibility --- bran content --- plasticized wheat flour --- citric acid --- biobased blends --- biopolymer --- carboxymethyl cellulose --- solid polymer electrolyte --- ionic transport --- chitosan --- potato starch --- microwave --- foam --- orthogonal experiments --- empty fruit bunch --- regenerated cellulose --- ionic liquid --- methyl methacrylate --- 3D printing --- syringe extrusion 3D printing --- hydroxypropyl methylcellulose --- orodispersible film --- phenytoin --- PA610 --- halloysite nanotubes (HNTs) --- flame retardant --- cone calorimeter --- agricultural waste --- asparagus --- CMC --- degree of substitution --- DS --- cellulose extraction --- thermoplastic starch --- dolomite --- biocomposite --- sonication --- bacterial cellulose --- nata de coco --- sodium hydroxide --- lignin --- nanoparticles --- biorefinery --- organosolv pretreatment --- polyelectrolyte multi-layers --- sodium alginate --- k-carrageenan --- cellulosic nonwoven textile --- surface functionalization --- characterization --- bio-sorption --- isotherms --- natural fibers --- soy protein --- chitin --- coir --- comfort --- functional textiles --- Circular Bioeconomy --- carbonation reaction --- selectivity optimization --- carbonated epoxidized linseed oil --- non-isocyanate polyurethane --- argan shell particles --- wood plastic composite --- polyethylene --- compatibilization --- air permeability --- fungal fibers --- hemp fibers --- microstructure --- mycocel --- softwood fibers --- virus membrane filtration --- allotropic transition --- choline chloride --- plasticizer --- starch dissolution --- n/a --- poly(3-hydroxybutyrate-co-3hydroxyhexanoate)-PHBH --- poly(ε-caprolactone)-PCL

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Nanomedicine is among the most promising emerging fields that can provide innovative and radical solutions to unmet needs in pharmaceutical formulation development. Encapsulation of active pharmaceutical ingredients within nano-size carriers offers several benefits, namely, protection of the therapeutic agents from degradation, their increased solubility and bioavailability, improved pharmacokinetics, reduced toxicity, enhanced therapeutic efficacy, decreased drug immunogenicity, targeted delivery, and simultaneous imaging and treatment options with a single system.Poly(lactide-co-glycolide) (PLGA) is one of the most commonly used polymers in nanomedicine formulations due to its excellent biocompatibility, tunable degradation characteristics, and high versatility. Furthermore, PLGA is approved by the European Medicines Agency (EMA) and the Food and Drug Administration (FDA) for use in pharmaceutical products. Nanomedicines based on PLGA nanoparticles can offer tremendous opportunities in the diagnosis, monitoring, and treatment of various diseases.This Special Issue aims to focus on the bench-to-bedside development of PLGA nanoparticles including (but not limited to) design, development, physicochemical characterization, scale-up production, efficacy and safety assessment, and biodistribution studies of these nanomedicine formulations.

Technology: general issues --- History of engineering & technology --- Materials science --- poly(lactic-co-glycolic acid) (PLGA) --- blood–brain barrier (BBB) --- current Good Manufacturing Practice (cGMP) --- Food and Drug Administration (FDA) --- nanotechnology --- PLGA nanoparticles --- neurodegenerative diseases --- drug delivery --- central nervous system --- neuroprotective drugs --- fluorescent labeling --- DiI --- coumarin 6 --- rhodamine 123 --- Cy5.5 --- quantum yield --- brightness --- stability of fluorescent label --- confocal microscopy --- intracellular internalization --- in vivo neuroimaging --- double-emulsion method --- dry powder inhalation --- antigen release --- porous PLGA particles --- microfluidics --- methotrexate --- chitosan --- PLA/PLGA --- sustained release --- micro-implant --- animal model --- minimally invasive --- drug delivery system --- nanoparticles --- poly (lactic-co-glycolic acid) (PLGA) --- microfluidic --- pharmacokinetics (PK) and biodistribution --- atorvastatin calcium --- poly(lactide-co-glycolide) --- polymeric nanoparticles --- carrageenan induced inflammation --- anti-inflammatory --- radiolabeled nanoparticles --- nuclear medicine --- photothermal therapy --- phthalocyanine --- SKOVip-kat --- Katushka --- TurboFP635 --- JO-4 --- PLGA --- orthotopic tumors --- 3D culture --- spheroids --- poly(lactic-co-glycolic acid) --- nanomedicine --- scale-up manufacturing --- clinical translation --- inline sonication --- tangential flow filtration --- lyophilization --- downstream processing --- H. pylori --- design of experiments --- poly(lactic-co-glycolic) acid --- size --- cancer --- chemoimmunotherapy --- immunogenic cell death --- immune checkpoint blockade --- PNA5 glycopeptide --- mas receptor --- angiotensin --- PLGA diblock copolymer --- ester and acid-end capped --- double emulsion solvent evaporation --- biocompatible --- biodegradable --- cardiovascular --- nanoparticle --- solid-state characterization --- in vitro --- drug release kinetics modeling --- PEGylation --- amine --- emulsion --- polyvinyl alcohol (PVA) --- Pluronic triblock copolymer --- trehalose --- sucrose --- Indomethacin --- solvents --- stabilizers --- morphology --- particle-size --- encapsulation --- drug release --- cytotoxicity

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This work covers all aspects related to the obtainment, production, design, and processing of biopolymers obtained from natural resources. Moreover, it studies characteristics related to the improvement of their performance to increase their potential application at an industrial level, in line with the concept of a global circular economy. Thus, this work firstly classifies biopolymers obtained from natural resources (e.g., biobased building blocks and biopolymers extracted directly from plants and biomass), and then summarizes several cutting-edge research works focused on enhancing the performance of biopolymers from natural resources to extend their application in the industrial sector, and contribute to the transition to more sustainable plastics.

Technology: general issues --- History of engineering & technology --- PHBH --- almond shell flour --- mechanical properties --- thermal characterization --- WPCs --- bacterial polyesters --- poly(3-hydroxybutyrate-co-3hydroxyhexanoate)-PHBH --- poly(ε-caprolactone)-PCL --- binary blends --- improved toughness --- mechanical and thermal characterization --- Cucumis metuliferus --- extraction --- antioxidant activity --- coating --- cellulose acetate --- LDPE --- bilayer packaging --- active packaging --- poly(lactic acid) --- mechanical recycling --- yerba mate --- bionanocomposites --- polysulfide-derived polymers --- cottonseed oil --- fatty acid of cottonseed oil --- sodium soap of cottonseed oil --- PLA --- nanocomposites --- functional properties --- thymol --- migration --- films --- cutin --- cuticles --- bioplastics --- biopolymers --- solanum: CPMAS 13C NMR --- softgels --- mucilage --- in vitro digestion --- bioaccessibility --- bran content --- plasticized wheat flour --- citric acid --- biobased blends --- biopolymer --- carboxymethyl cellulose --- solid polymer electrolyte --- ionic transport --- chitosan --- potato starch --- microwave --- foam --- orthogonal experiments --- empty fruit bunch --- regenerated cellulose --- ionic liquid --- methyl methacrylate --- 3D printing --- syringe extrusion 3D printing --- hydroxypropyl methylcellulose --- orodispersible film --- phenytoin --- PA610 --- halloysite nanotubes (HNTs) --- flame retardant --- cone calorimeter --- agricultural waste --- asparagus --- CMC --- degree of substitution --- DS --- cellulose extraction --- thermoplastic starch --- dolomite --- biocomposite --- sonication --- bacterial cellulose --- nata de coco --- sodium hydroxide --- lignin --- nanoparticles --- biorefinery --- organosolv pretreatment --- polyelectrolyte multi-layers --- sodium alginate --- k-carrageenan --- cellulosic nonwoven textile --- surface functionalization --- characterization --- bio-sorption --- isotherms --- natural fibers --- soy protein --- chitin --- coir --- comfort --- functional textiles --- Circular Bioeconomy --- carbonation reaction --- selectivity optimization --- carbonated epoxidized linseed oil --- non-isocyanate polyurethane --- argan shell particles --- wood plastic composite --- polyethylene --- compatibilization --- air permeability --- fungal fibers --- hemp fibers --- microstructure --- mycocel --- softwood fibers --- virus membrane filtration --- allotropic transition --- choline chloride --- plasticizer --- starch dissolution