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There have been recent significant improvements in the short-term survival of solid organ transplantation patients due to advances in immunosuppression and transplant techniques. However, long-term graft survival has still lagged behind other outcomes and has now become one of the main problems in solid organ transplantation.For this Special Issue, we invited researchers and clinicians to submit studies on solid organ transplantation. These have provided us with additional knowledge and skills that will ultimately help us to improve outcomes after solid organ transplantation.

Medicine --- Pharmacology --- living donation --- nephrectomy --- hand-assisted laparoscopic nephrectomy --- body composition --- complications --- simultaneous pancreas-kidney transplantation --- immunosuppression --- graft order --- sequence --- outcome --- survival --- kidney transplantation --- hydrogen --- diarrhea --- small intestinal bacterial overgrowth --- sickle cell disease --- sickle cell --- transplantation --- outcomes --- big data --- tacrolimus --- metabolism --- C/D ratio --- cholesterol --- dyslipidemia --- LDL-C --- liver transplantation --- hematuria --- chronic kidney disease --- tocilizumab --- clazakizumab --- desensitization --- anti-HLA alloantibody --- post traumatic growth --- psychiatric morbidity --- network analysis --- ESAS --- MINI --- CPC --- DCPR --- distress --- demoralization --- alexithymia --- anxiety --- antibody-mediated rejection --- recurrent primary disease --- renal transplantation --- pancreas transplantation --- cold ischemia time --- delayed graft function --- Eurotransplant Senior Program --- end-stage renal disease --- intensive care unit --- bioimpedance analysis --- drug dosing --- lean body mass index --- pharmacokinetics --- tacrolimus C/D ratio --- mineral bone disorder --- parathyroidectomy --- parathyroid hormone --- osteoporosis --- bone fractures --- Contrast-enhanced ultrasound --- kidney perfusion --- kidney function --- kidney donation --- n/a

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There have been recent significant improvements in the short-term survival of solid organ transplantation patients due to advances in immunosuppression and transplant techniques. However, long-term graft survival has still lagged behind other outcomes and has now become one of the main problems in solid organ transplantation.For this Special Issue, we invited researchers and clinicians to submit studies on solid organ transplantation. These have provided us with additional knowledge and skills that will ultimately help us to improve outcomes after solid organ transplantation.

Medicine --- Pharmacology --- living donation --- nephrectomy --- hand-assisted laparoscopic nephrectomy --- body composition --- complications --- simultaneous pancreas-kidney transplantation --- immunosuppression --- graft order --- sequence --- outcome --- survival --- kidney transplantation --- hydrogen --- diarrhea --- small intestinal bacterial overgrowth --- sickle cell disease --- sickle cell --- transplantation --- outcomes --- big data --- tacrolimus --- metabolism --- C/D ratio --- cholesterol --- dyslipidemia --- LDL-C --- liver transplantation --- hematuria --- chronic kidney disease --- tocilizumab --- clazakizumab --- desensitization --- anti-HLA alloantibody --- post traumatic growth --- psychiatric morbidity --- network analysis --- ESAS --- MINI --- CPC --- DCPR --- distress --- demoralization --- alexithymia --- anxiety --- antibody-mediated rejection --- recurrent primary disease --- renal transplantation --- pancreas transplantation --- cold ischemia time --- delayed graft function --- Eurotransplant Senior Program --- end-stage renal disease --- intensive care unit --- bioimpedance analysis --- drug dosing --- lean body mass index --- pharmacokinetics --- tacrolimus C/D ratio --- mineral bone disorder --- parathyroidectomy --- parathyroid hormone --- osteoporosis --- bone fractures --- Contrast-enhanced ultrasound --- kidney perfusion --- kidney function --- kidney donation

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In the 1980's, a research team led by Parisian scientists identified several unique DNA sequences, or haplotypes, linked to sickle cell anemia in African populations. After casual observations of how patients managed this painful blood disorder, the researchers in question postulated that the Senegalese type was less severe. The Enculturated Gene traces how this genetic discourse has blotted from view the roles that Senegalese patients and doctors have played in making sickle cell ""mild"" in a social setting where public health priorities and economic austerity programs have forced people to

Kinship --- Genetic disorders --- Sickle cell anemia --- Ethnology --- Clans --- Consanguinity --- Families --- Kin recognition --- Congenital diseases --- Disorders, Genetic --- Disorders, Inherited --- Genetic diseases --- Hereditary diseases --- Inherited diseases --- Diseases --- Medical genetics --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Health aspects --- Social aspects --- Patients --- Services for --- Genetic aspects. --- Africa. --- African anthropology. --- African genetics. --- African sicklers. --- Albert Royer Children's Hospital. --- CNTS. --- Centre nationale de transfusion sanguine. --- DNA haplotypes. --- DNA sequences. --- HbAS. --- International Organization for the Fight against Sickle Cell. --- National Blood Transfusion Center. --- OILD. --- RFLP. --- Restriction Fragment Length Polymorphism. --- Senegal. --- Senegalese attitudes. --- Senegalese sickle cell. --- alternative care. --- biological expressions. --- biosocial politics. --- culture. --- disease experiences. --- disease expression. --- economic austerity. --- economically triaged care. --- ethnic population purity. --- fagara. --- genetic difference. --- genetic sequence. --- geneticists. --- global health problems. --- global health. --- healing practices. --- health intervention. --- health. --- healthy sicklers. --- heterozygous sickle cell. --- low-tech strategy. --- multilateral institutions. --- normalization techniques. --- patient advocacy. --- political apathy. --- population. --- public health. --- public neglect. --- self-care. --- sickle cell DNA markers. --- sickle cell anemia. --- sickle cell gene. --- sickle cell research. --- sickle cell trait. --- sicklers. --- social networks. --- traditional plants. --- vitality.

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Discovered over 40 years ago, the annexin proteins were found to be a structurally conserved subgroup of Ca2+-binding proteins. While the initial research on annexins focused on their signature feature of Ca2+-dependent binding to membranes, over the years, the biennial “Annexin” conference series has highlighted additional diversity in the functions attributed to the annexin family of proteins. The roles of these proteins now extend from basic science to biomedical research, and are being translated into clinical settings. Research on annexins involves a global network of researchers and the 10th biennial Annexin conference brought together over 80 researchers from ten European countries, USA, Brazil, Singapore, Japan, and Australia for 3 days in September 2019. In this conference, the discussions focused on two distinct themes — the role of annexins in cellular organization and health and disease. The articles published in this Special Issue cover these two main themes discussed at the conference, offering a glimpse into some of the notable findings in the field of annexin biology

Research & information: general --- inflammation --- nigericin --- pyroptosis --- mass spectrometry --- lipidomics --- anxA2 --- Birbeck granules --- Langerhans cell --- A2t --- annexin --- plasma membrane repair --- membrane curvature --- membrane curvature sensing --- membrane shaping --- interdisciplinary research --- cell rupture --- membrane damage --- bias analysis --- G protein-coupled receptor (GPCR) --- formyl peptide receptor 1 --- danger-associated molecular pattern (DAMP) --- pathogen-associated molecular pattern (PAMP) --- annexin A1 peptide Ac2-26 --- cholesterol --- AnxA6 --- chaperone-mediated autophagy --- endolysosomes --- NPC1 --- Lamp2A --- annexin A2 --- microdomain --- cross-linker --- quartz crystal microbalance with dissipation monitoring (QCM-D) --- mucin-1 --- claudin-1 --- zona occludens --- ERK1/2 pathway --- angiogenesis --- F-actin polymerization --- BeWo spheroids --- Ishikawa cells --- influenza --- RNA-sequencing --- transcriptomics --- autophagy --- Annexin-A1 --- infection --- adherens junction --- macroautophagy --- breast cancer --- estrogen receptor negative --- Annexin A2 --- metastasis --- annexin-A6 --- membrane repair --- human skeletal muscle --- cap subdomain --- fluorescence --- electron microscopy --- CLEM --- annexin A6 --- RasGRF2 --- EGFR --- cell growth --- cell motility --- acquired resistance --- tyrosine kinase inhibitors --- muscle injury --- plasma membrane --- vesicle --- muscular dystrophy --- annexinA2 egress --- exocytosis --- chromaffin cells --- thrombosis --- Annexin A1 --- formyl peptide receptors --- sickle cell disease --- sepsis --- Annexin --- membrane --- injury --- virus --- lipid --- cancer