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This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.

Nuclear receptors (Biochemistry). --- Nuclear hormone receptors --- Receptors, Nuclear (Biochemistry) --- Receptors, Nuclear hormone --- Hormone receptors --- Transcription factors --- Medicine --- Biology --- Molecular biology. --- Metabolism. --- Genetics. --- Cytology. --- Biomedical Research. --- Molecular Biology. --- Genetics and Genomics. --- Cell Biology. --- Research. --- Health Workforce --- Cell biology --- Cellular biology --- Cells --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Biological research --- Biomedical research --- Receptors nuclears (Bioquímica)

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Nuclear Receptors are inducible transcription factors that mediate complex effects on development, differentiation and homeostasis. They regulate the transcription of their target genes through binding to DNA sequences.*Analysis of Nuclear Receptor Ligands*Structure/Function Analysis of Nuclear Receptors*Analysis of Nuclear Receptor Co-Factors and Chromatin Remodeling

Nuclear receptors (Biochemistry). --- Laboratory Chemicals --- Proteins --- DNA-Binding Proteins --- Investigative Techniques --- Transcription Factors --- Biochemical Phenomena --- Pharmacological Phenomena --- Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Amino Acids, Peptides, and Proteins --- Specialty Uses of Chemicals --- Chemical Phenomena --- Phenomena and Processes --- Chemical Actions and Uses --- Chemicals and Drugs --- Receptors, Cytoplasmic and Nuclear --- Structure-Activity Relationship --- Models, Animal --- Ligands --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Animal Experimentation --- Relationship, Structure-Activity --- Relationships, Structure-Activity --- Structure Activity Relationship --- Structure-Activity Relationships --- Cytoplasmic Hormone Receptors --- Cytoplasmic Receptors --- Cytosol and Nuclear Receptors --- Intracellular Membrane Receptors --- Nuclear Hormone Receptors --- Nuclear Receptors --- Receptors, Cytoplasmic --- Receptors, Cytosol and Nuclear --- Receptors, Cytosolic and Nuclear --- Receptors, Intracellular Membrane --- Receptors, Nuclear --- Receptors, Nuclear and Cytoplasmic --- Cytoplasmic and Nuclear Receptors --- Cytosolic and Nuclear Receptors --- Hormone Receptors, Cytoplasmic --- Hormone Receptors, Nuclear --- Nuclear and Cytoplasmic Receptors --- Membrane Receptors, Intracellular --- Receptors, Cytoplasmic Hormone --- Receptors, Nuclear Hormone --- Hormones --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Chemical Processes --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- Specialty Chemicals and Products --- Physiological Concepts --- Physiological Phenomenon --- Physiological Process --- Physiological Processes --- Concept, Physiological --- Concepts, Physiological --- Phenomena, Physiological --- Phenomenas, Physiological --- Phenomenon, Physiological --- Physiological Concept --- Process, Physiological --- Processes, Physiological --- Pharmacologic Phenomena --- Pharmacologic Phenomenon --- Pharmacologic Process --- Pharmacological Concepts --- Pharmacological Phenomenon --- Pharmacologic Processes --- Pharmacological Processes --- Concept, Pharmacological --- Concepts, Pharmacological --- Pharmacological Concept --- Phenomena, Pharmacologic --- Phenomena, Pharmacological --- Phenomenon, Pharmacologic --- Phenomenon, Pharmacological --- Process, Pharmacologic --- Processes, Pharmacologic --- Processes, Pharmacological --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Processes --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- Molecular Biology --- Transcription Factor --- Factor, Transcription --- Factors, Transcription --- Gene Expression Regulation --- Transcription, Genetic --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- DNA Binding Protein --- DNA Single-Stranded Binding Protein --- SS DNA BP --- Single-Stranded DNA-Binding Protein --- DNA Helix Destabilizing Proteins --- Single-Stranded DNA Binding Proteins --- Binding Protein, DNA --- DNA Binding Proteins --- DNA Single Stranded Binding Protein --- DNA-Binding Protein, Single-Stranded --- Single Stranded DNA Binding Protein --- Single Stranded DNA Binding Proteins --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Chemicals, Laboratory --- Ligand --- Cytoplasmic Receptor --- Nuclear Hormone Receptor --- Nuclear Receptor --- Hormone Receptor, Nuclear --- Receptor, Cytoplasmic --- Receptor, Nuclear --- Receptor, Nuclear Hormone --- DNA-Binding Protein --- Protein, DNA-Binding --- Protein --- Hormone receptors. --- Nuclear receptors (Biochemistry) --- Receptor-ligand complexes.