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Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.

DNA damage --- DNA repair --- Free radicals (Chemistry) --- ADN --- ADN --- Radicaux libres (Chimie) --- Lésions --- Réparation --- EPUB-LIV-FT LIVBIOLO SPRINGER-B

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Inflammation --- Free radicals (Chemistry) --- Active oxygen --- Nitric oxide --- Radicaux libres (Chimie) --- Oxygène actif --- Monoxyde d'azote --- Pathophysiology. --- Pathophysiology. --- Pathophysiology. --- Pathophysiology. --- Physiopathologie --- Physiopathologie --- Physiopathologie

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Free radicals (Chemistry) --- Biochemistry. --- Antioxidants. --- Pathology, Molecular. --- Free Radicals --- Oxidation-Reduction --- Antioxidants --- Oxidative Stress --- Radicaux libres (Chimie) --- Antioxydants --- Pathologie moléculaire --- Physiological effect. --- Physiological effect --- Effets physiologiques --- Clinical biochemistry --- Pathology, Molecular --- Oxidative Stress. --- Radicaux libres (chimie) --- Stress oxydatif --- Pathologie moléculaire --- Free Radicals. --- Oxidation-Reduction. --- Antioxydants. --- Pathologie moléculaire. --- Stress oxydatif. --- Effets physiologiques.

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fysicochemie --- Organic reaction mechanisms and kinetics --- Free radicals (Chemistry) --- Radicaux libres (Chimie) --- 541.515 --- Free radicals --- Radicals (Chemistry) --- Free radical reactions --- Free radicals (Chemistry). --- 541.515 Free radicals --- Gases. --- Reaction (chemistry) --- Reaction kinetics --- Reaction mechanism --- Solutions (chemistry)

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Antioxidants --- Free Radicals --- Oxidants --- Free radicals (Chemistry) --- Antioxydants --- Radicaux libres (Chimie) --- therapeutic use --- adverse effects --- Therapeutic use --- Pathophysiology --- Emploi en thérapeutique --- Physiopathologie --- Voedingsleer: antioxidanten --- Free Radicals. --- Therapeutic use. --- Pathophysiology. --- therapeutic use. --- adverse effects. --- Emploi en thérapeutique --- Adverse effects.